HIV/AIDS
HIV prevention, treatment, Ryan White programs, and AIDS services.
Supporting Interventions with Technical Assistance
The purpose of this funding opportunity is to fund one organization to implement and evaluate tailored technical assistance (TA) to Ryan White HIV/AIDS Program (RWHAP) recipients. The purpose of this initiative is to support the uptake of interventions by providing tailored, needs-based TA to RWHAP recipients and providers to address barriers to intervention start-up, such as competing priorities and not knowing how to adapt interventions to fit their organizational structures or client populations. By providing tailored TA and a one-time funding amount to cover start-up costs, RWHAP recipients and providers will be able to address these barriers and strengthen their ability to integrate and sustain innovative HIV care models. The adoption of these interventions across the HIV health care system will improve HIV health outcomes and reduce transmission of HIV. This funding opportunity is supported by the HRSA RWHAP Part F: Special Projects of National Significance (SPNS) Program. Funding supports an implementation science approach to adapt, implement, and evaluate the implementation of HIV care innovations. It also builds upon previous and current projects to increase the uptake of disseminated interventions that have been funded by HRSA’s HIV/AIDS Bureau (HAB). The proposed initiative will identify a representative set of RWHAP recipient and/or provider sites (up to 20 sites funded as subrecipients by the recipient, divided into two (2) phases) to receive short-term, tailored implementation support and resources to jump start efforts to adapt or replicate existing interventions. The recipient will work with the sites to understand their specific needs and organizational structure to develop tailored resources and TA to adapt or replicate selected emerging, evidence-informed, and evidence-based interventions and other HIV care innovations.
Ryan White HIV/AIDS Program Part F Dental Reimbursement Program
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part F Dental Reimbursement Program (DRP) is to improve access to oral health care services for low-income people with HIV, and related education and training to dental providers serving people with HIV. Authorized under section 2692(b) of the Public Health Service Act (42 U.S.C. § 300ff–111(b)), the DRP provides partial reimbursement to eligible dental schools and accredited dental hygiene programs for the unreimbursed costs of oral health care provided to patients with HIV. Eligible institutions may annually apply for reimbursement based on costs incurred in the prior year. Available funds are distributed among all eligible applicants, taking into account the number of patients with HIV served and the extent of unreimbursed care costs relative to other applicants.
Strategies to Link, Engage, and Retain Men with HIV in Care: Evaluation Provider
The purpose of this funding opportunity is to award one cooperative agreement recipient to serve as the Evaluation Provider (EP). This funding opportunity has a companion funding opportunity to fund an Implementation Technical Assistance Provider (ITAP). The two recipients will work collaboratively, but conduct distinct activities that support the overall initiative. The proposed initiative will be comprised of one Evaluation Provider (EP), one Implementation Technical Assistance Provider (ITAP) funded as a separate cooperative agreement, and up to eight (8) implementation sites sub-awarded by the ITAP. This initiative will use implementation science to adapt, implement, and evaluate the implementation of interventions that serve men with HIV who are not consistently engaged in care or experiencing barriers to staying in care This initiative directly aligns with Ryan White Program 2030 (RWP2030), which is a renewed vision for the Ryan White HIV/AIDS Program (RWHAP). Building on the foundation of the RWHAP and the Ending the HIV Epidemic in the U.S. initiative, the RWP2030 framework is designed to sustain high-quality care and treatment for people currently receiving services through the RWHAP while expanding efforts to identify and engage individuals with HIV who are undiagnosed or out-of-care. The funded Evaluation Provider (EP) will lead a multi-site evaluation of the project and will provide evaluation-specific technical assistance (TA) to the implementation sites. The evaluation activities that the EP will conduct will draw from frameworks and approaches developed in the field of implementation science, including HAB’s Implementation Science Framework. The initiative emphasizes: 1) rapid adaptation, implementation, and evaluation; 2) implementation at a broad scale to produce generalizable findings; 3) public release of dissemination products based on human-centered design and adult learning principles, which foregrounds sustainability, rapid dissemination of findings, and replication of best practices.
Strategies to Link, Engage, and Retain Men with HIV in Care: Implementation Technical Assistance Provider
The purpose of this funding opportunity is to award one cooperative agreement recipient to serve as the Implementation Technical Assistance Provider (ITAP). This funding opportunity has a companion funding opportunity to fund an Evaluation Provider. The two recipients will work collaboratively, but conduct distinct activities that support the overall initiative. The proposed initiative will be comprised of one Implementation Technical Assistance Provider (ITAP), which will sub-award up to eight (8) implementation sites. The funded ITAP will solicit and select the implementation sites, as well as to identify emerging and evidence-informed interventions to be adapted and implemented by the implementation sites. The ITAP will be responsible for managing the subawards and providing implementation-specific technical assistance (TA) for the implementation sites. The proposed initiative will use implementation science to adapt, implement, and evaluate the implementation of interventions that serve men with HIV who are not consistently engaged in care or experiencing barriers to staying in care. This initiative directly aligns with Ryan White Program 2030 (RWP2030), which is a renewed vision for the Ryan White HIV/AIDS Program (RWHAP). Building on the foundation of the RWHAP and the Ending the HIV Epidemic in the U.S. initiative, the RWP2030 framework is designed to sustain high-quality care and treatment for people currently receiving services through the RWHAP while expanding efforts to identify and engage individuals with HIV who are undiagnosed or out-of-care. The funded ITAP will manage the subawards, identify emerging and evidence-informed interventions to be adapted and implemented by the implementation sites, and provide implementation-specific TA to the implementation sites. The adaptation and implementation activities the ITAP will conduct will draw from frameworks and approaches developed in the field of implementation science including HAB’s Implementation Science Framework. The initiative emphasizes: 1) rapid adaptation, implementation, and evaluation; 2) implementation at a broad scale to produce generalizable findings; 3) public release of dissemination products based on human-centered design and adult learning principles, which foregrounds sustainability, rapid dissemination of findings, and replication of best practices.
Ryan White HIV/AIDS Program Part C Capacity Development Program
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part C Capacity Development program is to strengthen organizational capacity to increase capacity to develop, enhance, or expand access to high quality HIV primary health care services for low-income people with HIV. The proposed activity should be of a short-term nature and should be completed by the end of the one-year funding opportunity period of performance. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials
The National Institute on Drug Abuse seeks to support pilot and feasibility studies in preparation for efficacy, effectiveness and/or services research trials. Topics may include:1) developing interventions to prevent substance use, misuse or progression to disorder, 2) substance use prevention, treatment or recovery services research, including comorbid pain, medical and mental health disorders, 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations. Projects may address information gaps, strengthen stakeholder partnerships, or pilot test interventions. Activities might include intervention development/adaptation; assessing intervention or service model acceptability and feasibility; and development of measures, materials, or methods for the future trial. Preliminary data is not required. A well-defined theory of change or logic model is expected. Applicants must engage relevant end users in study design, execution, and interpretation (e.g., policymakers, state and local decision makers, practitioners, individuals with lived/living experience, families, youth, and community members). Applications are not being solicited at this time. This notice is to allow applicants time to develop collaborations and responsive projects. Grant authorities that allow this forecast are 42 U.S.C. §§ 241 and 284.
Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY) Existing Geographic Service Areas
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services). The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV, to directly remove barriers to care for the person with HIV, or to promote family stability.
Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services. The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV , to directly remove barriers to care for the person with HIV, or to promote family stability. The purpose of this supplemental funding is to strengthen organizational capacity to respond to the changing health care landscape and increase access to high quality family-centered HIV primary health care services for low-income women, infants, children and youth (WICY) with HIV. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Centers for AIDS Research (CFAR)
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for the Centers for AIDS Research (CFAR). The national network of CFARs cooperates with other HHS-funded HIV/AIDS programs to establish and maintain the collaborations and infrastructure required to carry out innovative implementation science research for ending the HIV epidemic domestically. Addressing a complex chronic disease, HIV/AIDS research requires broad scientific expertise, access to unique biological samples, and cutting-edge research technologies that extend beyond the needs of individual research groups. The CFAR program strengthens HIV/AIDS research by providing infrastructure that fosters multidisciplinary collaborations, maximizes efficiencies by reducing duplication of efforts, and leverages economies of scale to facilitate the translation of basic research findings into new HIV treatment, prevention, and cure approaches. A core mission of the CFAR program is to support and mentor early-career investigators and investigators new to HIV/AIDS research by funding pilot studies, emerging research opportunities, and high-risk/high-impact collaborative studies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Implementation Science to End the HIV Epidemic
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for implementation science to end the HIV epidemic. Projects will leverage research-community collaborations to bring evidence-based advances in HIV prevention, diagnosis, treatment, and cluster outbreak response to communities disproportionately impacted by HIV. The goals of these projects will be to: (1) Develop strategies to end HIV by integrating innovations across disciplines such as epidemiology, data science, public health, medicine, social services, implementation science, and community engagement, and (2) Deploy, test, and evaluate new or existing strategies at multiple geographic locations or settings. While deployment of these strategies will occur at the local scale, through partnerships with, local, state, and federal public health partners, the overall program will advance generalized knowledge that informs larger scale efforts to end HIV. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Strengthening and modernizing Uganda's sustainable public health systems and workforce in data science, informatics, and surveillance to produce timely, accurate, and integrated data for action
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $30,000,000 for Year 1, subject to the availability of funds. This NOFO supports the Ministry of Health (MOH)-led digital transformation vision to modernize Uganda’s health data systems and infrastructure. It also supports enhancing capacity to provide timely epidemic intelligence for critical decision-making in HIV and related health programs. The data architecture is expected to encompass: General and targeted surveys.Clinical systems such as electronic medical records (EMR).Digital registers.Clinical indicator-based surveillance.Disease surveillance.Laboratory data.Commodities, logistics, and pharmacy management information systems.Community data.Human resource management and development.Other data collection activities to address existing data and knowledge gaps. The NOFO also supports developing digital solutions and strengthening data warehousing, integration, and interoperability to build a sustainable and resilient digital ecosystem ready for transition to local governance.
Sustaining life-saving HIV services in Ukraine by strengthening resilient health systems under the Ukraine Ministry of Health, Public Health Center
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $10,000,000 for Year 1, subject to the availability of funds. This NOFO aims to help the Public Health Center (PHC) of the Ministry of Health (MOH) enhance life-saving assistance for HIV and associated prevalent health conditions. This should be accomplished with targeted HIV testing, prevention, and treatment activities amid ongoing instability. The objectives of this NOFO include: Working to ensure that targeted HIV testing, treatment, retention, and prevention services are widely available for people who are at higher risk for HIV. Services should be provided in community settings using social network strategies (SNS). Activities include:Targeted community-based case finding.Immediate linkage to available treatment.Retention support.Management of advanced HIV disease and HIV/TB co-infection.Improving the availability of HIV services by mobile HIV testing, treatment, and prevention. You should use targeted mobile HIV case finding, treatment, retention, and prevention services. Activities include:Streamlining immediate linkage to treatment.Strengthening ongoing adherence support.Improving the availability and quality of HIV services at medical facilities by implementing differentiated service delivery (DSD) models. Activities include enhancing patients’ retention, adherence, and access to HIV services at the facility level.Enhancing essential, targeted HIV prevention service provision for people at higher risk for HIV, focusing on availability, quality, coverage and timely initiation.
Providing technical support and capacity building for the Government of Mozambique and local organizations for life-saving HIV and TB and public health care services in the Republic of Mozambique
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $15,000,000 for Year 1, subject to the availability of funds. This NOFO is intended to support the Government of the Republic of Mozambique (GRM) expand life-saving HIV and TB and other health services throughout the country. It focuses on improving the approach to technical support and capacity building to transition to GRM provincial directorate-led HIV and TB service in line with the goals laid out by the Mozambique Ministry of Health (MISAU) and the U.S. government (USG). This NOFO is expected to strengthen existing capabilities and provide technical support for sustainable direct service delivery (DSD) of integrated life-saving HIV and TB services in Mozambique. This includes support for national-level activities like MISAU’s capacity building for technical guidelines, policy, and training curricula development, and updates. This NOFO is expected to also address gaps in human resources for health (HRH) at the national and provincial level. This includes developing and implementing training for healthcare staff and using novel training platforms, such as virtual modalities and tele-medicine.
Engaging faith-based organizations to sustain lifesaving HIV and TB services in Ethiopia
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $5,000,000 for Year 1, subject to the availability of funds. This NOFO will engage faith-based organizations (FBOs) to support and sustain lifesaving HIV, TB, and cervical cancer services in Ethiopia. HIV services will include: • HIV testing. • HIV prevention, including vertical transmission. • Adult and pediatric HIV care and treatment. Through this project, you will work with faith communities to provide and link people with lifesaving HIV services. You will serve: • People at high risk of acquiring HIV. • Undiagnosed people living with HIV • People living with HIV at risk of interrupting their treatment. • Pregnant and breastfeeding women. • People living with HIV who may face barriers to accessing conventional health facility services. You will be expected to implement cost-efficient models and integrate them with the routine health-care delivery system to reach undiagnosed people living with HIV, people living with HIV who have defaulted from care, and people at high risk of acquiring HIV, ensuring their access to critical, lifesaving HIV and TB services. This NOFO will support activities that promote country ownership and country-led plans that enable greater sustainability. Programs supporting other public health threats and emergencies in Ethiopia may also be included in this NOFO.
Strengthening Botswana's national data, performance management, and surveillance systems for a sustainable and government-led HIV, TB, and related public health response
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $4,000,000 for Year 1, subject to the availability of funds. This NOFO aims to provide targeted strategic assistance to the Government of Botswana (GOB) to strengthen health security and national data systems. It focuses on: Governance and policies.Capacity building to sustainably manage data.System functionality, interoperability, and data use.You are expected to support the GOB to help ensure that comprehensive, quality HIV-related strategic information and health security systems operate effectively at the site, district, and national levels. Your activities should include: Transferring skills and management of technology systems to GOB so it can operate, maintain, and use current facility, community, and national data systems. These systems include any paper and electronic record systems necessary to manage patients and monitor programs that deliver lifesaving HIV and TB care, treatment, and targeted prevention services.Transferring skills and technology related to existing country data systems to GOB. This includes systems that ensure routine program monitoring, oversight, compliance, and reporting. This also includes enhancing workforce knowledge and skills to operate, maintain, and secure the systems and analyze data.Strengthen the health security capacities of the GOB and relevant interest holders to surveil, respond to, and control public health events and disease outbreaks across all administrative levels.
Improving regional capacity to respond to HIV, TB, and other global health priorities in Central America
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $20,000,000 for Year 1, subject to the availability of funds. You will advance progress towards achieving the 95-95-95 targets and continue to transition site-level support to local governments in Central America (CA) for: El Salvador.Guatemala.Honduras.Nicaragua.Panama.To achieve the goals of this NOFO, you will address gaps in: HIV prevention.Diagnosis.Life-saving treatment.Proposed activities should facilitate country ownership while improving local capacity to: Make sure HIV prevention is available for populations most at risk, through the Sentinel Surveillance of STI and HIV Strategy (VICITS).Provide testing that leads to active linkage to HIV treatment and prevention services.Improve early HIV diagnosis through active case-finding strategies, including:Testing as outreach for populations most at risk for HIV.Index, provider-initiated, and community testing.Social network strategy.Self-testing.Support the integration of comprehensive care and treatment services, including for HIV, TB, and other opportunistic infections.Build capacity of healthcare workers to provide high-quality health services led by the country, and through continuous quality improvement (CQI) initiatives.Make sure adequate data systems are used to monitor progress toward 95-95-95 targets and other global health priorities.Support sustainable health systems that improve:Efficiency.Country ownership of the program.Global health security to fight priority infectious diseases and other public health threats.
Enhancing sustainable health information and laboratory systems and networks for quality detection, management, and monitoring to end HIV and TB as public health threats in India
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $6,000,000 for Year 1, subject to the availability of funds. CDC invites proposals to support India’s Ministry of Health and Family Welfare (MOHFW), National AIDS Control Organization (NACO), and related institutions to strengthen health systems and laboratory networks for HIV, TB, and other public health concerns. It aligns with the America First Global Health Strategy (AFGHS) to bolster health systems to prevent the global spread of infectious disease. You should enhance innovative, cost-effective, and quality-assured laboratory services for HIV, TB, and related health programs by focusing on early detection, service delivery, and monitoring in priority regions. Strategic support will foster ownership, integrate broader health systems, and align with U.S. global health priorities. Activities include: Optimizing health information and laboratory networks for HIV, TB, and co-infections to enhance access, early detection, and boost capacity for other public health concerns.Enhancing surveillance of infectious disease threats by integrating national data systems for coordinated public health action.Reinforcing biosafety, biosecurity, and laboratory quality systems.Adopting innovative technologies to meet disease containment goals.Supporting molecular diagnostics and epidemiology to track transmission networks and drug resistance for infectious diseases, focusing on HIV and co-infections.Strengthening the health workforce to collect, analyze, and use data to improve patient care, feedback systems, and epidemic trend monitoring.
Ending the HIV/HCV Epidemics in Indian Country
The purpose of this program is to support communities to directly increase the diagnoses, treatment, and prevention of HIV, HCV, and syphilis. Successful applicants will work toward a re-duction of new HIV infections and relevant co-morbidities, specifically syphilis and HCV infections; improve HIV/HCV/syphilis-related health outcomes; and reduce HIV/HCV/syphilis-related health disparities among the AI/AN population. In four separate but related parts, this initiative aims to implement effective and innovative strategies, interventions, approaches, and services to reduce new HIV/HCV/syphilis infections among AI/AN communities in the U.S. This initiative’s overarching goals are to: (1) Reduce new HIV, HCV, and syphilis infections to less than 3,000 per year by 2030; and (2) achieve a 90 percent reduction in new HCV infections and a 65 percent reduction in mortality, compared to a 2015 baseline.
Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials
The Eunice Kennedy Shriver National Institute of Child Health and Human Development intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research focused on high-priority HIV studies for infants, children, youth and young adults (AYA), and maternal populations. An HIV clinical trials network focused exclusively on pediatric and maternal populations will innovate and conduct rigorously designed, collaborative clinical trials in partnership with site consortia to address high-priority research areas in HIV and related comorbidities and coinfections. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UM2 activity code. Investigators with expertise and insights into this area of HIV are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in chronic and infectious diseases, pediatrics, adolescent medicine, laboratory innovation, and cost-effectiveness will be encouraged and these investigators should also begin considering applying for this application.
Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)
The National Institue on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on pioneering research in HIV and Substance use/substance use disorder (SUD) research. The Avant-Garde Award Program is designed to support exceptionally creative scientists who propose cutting edge high risk and high reward and possibly transformative approaches to major challenges in biomedical and behavioral research on HIV in the context of substance use and/or SUDs. This Program includes supporting early stage investigators (ESI). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the DP1 activity code. Investigators with expertise and insights into this area of substance use and HIV are encouraged to begin to consider applying for this new NOFO.
HIV Prevention and Alcohol (R01 Clinical Trials Optional)
The NOFO seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. This includes integration of effective prevention and treatment interventions with an understanding of the overarching framework for reducing the incidence of new infections by facilitating cross-cutting informative research. This research activity includes the development and testing of new interventions and expansion of existing effective interventions as well as the implementation of these integrative preventive activities in a variety of settings and populations. Six areas of research are of primary interest related to alcohol use and related mental health and substance use comorbidities. These include but are not limited to 1) PrEP Utilization, 2) Treatment as Prevention (TasP), 3) Integration of Preventive Intervention Strategies, 4) Prevention-related Cross-cutting Research, 5) Syndemic Approaches and, 6) Implementation and Operations Research.