Health Infrastructure
Facilities, construction, and health infrastructure funding.
Behavioral Health Partnerships for Early Diversion of Adults and Youth
The purpose of this program is to develop and implement infrastructure that supports programs that divert adults and/or youth with a mental illness or a co-occurring substance use disorder from the criminal and/or juvenile justice systems prior to arrest and booking.
Mental Health Awareness Training Grants
The purpose of this program is to facilitate the implementation of mental health awareness and literacy training.
Public Health Strategies to Address Alzheimer's Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator
Alzheimer's disease, the most common form of dementia, is a progressive condition. It begins with mild memory loss and may lead to the inability to communicate or respond to one's environment. Its prevalence is rising with the aging U.S. population. In 2021, it was the 5th leading cause of death for those 65 and older, with death rates continuing to climb. The CDC Alzheimer's Disease Program, through the National Healthy Brain Initiative (HBI) and funded partners, promotes brain health, addresses cognitive impairment, and supports caregivers using evidence-based approaches. This funding opportunity aligns with the HBI Road Map Series (including the State and Local Road Map 2023–2027 and the Road Map for Indian Country) and fulfills the aims of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406). Funding Structure: Component 1: National Healthy Brain Initiative: Funds up to two (2) organizations to develop and implement public health strategies guided by the HBI Road Map Series. Funded organizations will: Develop evidence-informed training for health care and public health professionals on ADRD and caregiving. Expand the availability and use of public health surveillance data, including adaptation & revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline and caregiver optional modules. Facilitate the coordination of recipients and national partners to address ADRD. Funding range: $2,500,000 to $3,000,000 per 12-month budget period. Component 2: BOLD Public Health Centers of Excellence: Funds three (3) Centers, each specializing in one of three topic-specific areas: dementia risk reduction, early detection and management of dementia, or dementia caregiving. Centers will: Support the needs of the BOLD public health program and other public health agencies. Identify, disseminate, and promote best practices. Translate promising research into practical tools and resources. Increase professional education and develop materials to address specific individual needs to improve health outcomes. Funding range: $750,000 to $1,000,000 per 12-month budget period. Component 3: ADRD Public Health Adoption Accelerator. Funds up to two (2) organizations to serve as public health strategy adaptation accelerator programs. This means using dissemination and implementation of science to spread and put into practice effective public health strategies, tools, and resources to tackle ADRD. Organizations will: Collaborate with CDC and other organizations to create a prioritized list of ADRD approaches & strategies. Use proven strategies to engage partners, health care organizations, and policymakers to enhance uptake and implementation, accelerating the impact of ADRD efforts. Provide technical assistance to Component 1 & 2 recipients. Funding range: $750,000 - $1,200,000 per 12-month budget period. Applicants may apply for multiple components, but must submit a separate application per component.
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit research applications for practice-based research centers to support interdisciplinary teams of mental health researchers to engage in high-impact studies that will significantly advance clinical practice and generate knowledge to fuel the transformation of mental health care in the United States. Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers support research projects aimed at the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders; (2) developing and testing empirically informed patient-, provider- and system-level interventions to improve mental health care access, engagement, continuity, efficiency, and quality; and (3) continuously improving the quality, impact, and durability of optimized interventions and health for individuals with or at risk for mental health problems, including those with serious mental illness. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive research projects. This NOFO will utilize the P50 activity code. Applications must propose research that maximizes synergies across various components of the mental health research ecosystem, including new discoveries in clinical research, transformative health care technologies, advances in information science, and new federal and state mechanisms for organizing mental health care. Applicants with interdisciplinary expertise, such as behavioral science, health information and data science, health systems engineering, decision science, implementation science, and related fields, whose practice-based research needs cannot be met through standard research project grant mechanisms, should consider applying to this NOFO. Applications are also expected to include research activities that facilitate the widespread sharing of data, methods, and resources to accelerate clinical research and to provide opportunities for graduate students, postdoctoral researchers, and early-career investigators to participate in interdisciplinary research-to-practice translational mental health research.
Make America Healthy Again – Enhancing Lifestyle and Evaluating Value-based Approaches Through Evidence
The Centers for Medicare & Medicaid Services (CMS), through its Centers for Medicare and Medicaid Innovation (CMMI or Innovation Center), is soliciting applications for the Make America Healthy Again: Enhancing Lifestyle & Evaluating Value-based Approaches Through Evidence (MAHA ELEVATE) Model. This voluntary, three-year service delivery model is designed to test evidence-based, whole-person functional or lifestyle medicine (“whole-person FLM”) approaches to care. Rather than treating diseases separately after they develop, MAHA ELEVATE takes a proactive, comprehensive approach that combines psychological, nutritional, and physical interventions with personalized, lifestyle-based strategies for prevention and early treatment. Throughout this NOFO, we use the term “whole-person FLM” to represent a range of services or approaches often incorporated in lifestyle and functional medicine that are not currently covered under Medicare. It is important to clarify that CMS is not establishing a new industry standard through the use of this terminology. The term “whole-person FLM” as used in this NOFO does not represent an attempt by CMS to create, define, or establish any new industry-wide standard, practice guideline(s), or healthcare delivery model beyond the scope of this specific Innovation Center model and funding opportunity. Similarly, through this funding opportunity, CMS is not creating a new category of covered services for Medicare purposes. This term serves solely as a descriptive reference within this document to facilitate clear communication about the non-covered services being tested in this model and should not be interpreted as having any regulatory, coverage, or policy implications beyond the context of this specific Innovation Center model. CMS will select a total of up to 30 Recipients to participate in MAHA ELEVATE. The model will be split into two cohorts, one year apart (years 2026 and 2027). CMS will select recipients based on five key criteria: • Whole-person FLM intervention design, including cost savings. • Beneficiary recruitment and study design. • Organizational and administrative capacity. • Data management capabilities. • Budget. Highly competitive applicants must demonstrate several important strengths: • Strong, evidence-based support for your proposed intervention(s) and proof of your own successful history of implementation of the intervention and cost savings. • Ability to recruit large numbers of participants with a clear randomization plan and advanced data management capabilities. Given the model’s minimum beneficiary targets and extensive data management requirements, applicants who do not directly provide clinical care are strongly encouraged to form partnerships with care entities or organizations that deliver clinical care. This collaboration helps ensure you can meet the full operational requirements of the program.
Assisted Outpatient Treatment Program
The purpose of this program is to facilitate the implementation of AOT for adults with serious mental illness. Recipients are expected to implement the AOT program, working with civil courts, community partners, and other entities to support community-based treatment for adults with SMI who meet criteria for AOT.
2026 Community Wood Energy and Wood Innovation Program
The USDA Forest Service is delivering the Community Wood Energy and Wood Innovation Program (Community Wood) to support the Rural Revitalization Technologies 7 U.S.C. Sec. 8113 and Agriculture Improvement Act of 2018 Pub. L. 115-334 Sec. 9013, and Infrastructure Investment and Jobs Act (Bipartisan Infrastructure Law) Pub. L. 117-58 Div. J Title VI which directly support the installation of thermally led community wood energy systems or development and expansion of innovative wood product facilities. The intent of the Community Wood is to support forest health and stimulate local economies by expanding renewable wood energy use and innovative wood products manufacturing capacity. The Forest Service solicits proposals for projects that will achieve the following: Expand thermally led community wood energy or innovative wood product opportunities; Improve Forest health; and Stimulate local economies. This funding opportunity is intended for shovel ready projects that will not require additional funding or time to complete after the award period. Examples of eligible projects include, but are not limited to: Install a thermally led community wood energy system for heating, cooling, and/or electricity that replaces fossil fuels such as coal, oil, propane, or natural gas. Purchase and install manufacturing equipment at a mass timber production facility. Expand a sawmill to add higher value production lines that incorporate innovative technologies and cost cutting measures. Purchase and install equipment at a new facility to produce biofuels from forest residues. All awards are based on funding availability. The Forest Service plans to award up to $6 million in total awards under this announcement. The maximum for each award is $1 million to pay for up to 35% of total capital costs. The Forest Service may consider awarding up to $1.5 million (for up to 50% of total capital costs) for a proposal that warrants special consideration, especially for projects located in areas of high unemployment. Matching funds are not required; however, leveraging is required. Applicants must contribute the remaining funds (leveraged funds) necessary to complete the project above and beyond the requested Forest Service funding. For example, if an applicant requests Forest Service funding for 35% of the total capital costs of the project, then the applicant must commit to providing 65% of the total capital costs of the project. In this example, the 65% of the total capital costs are considered the required leveraged funds. Even though leveraged funds have a lower reporting burden and fewer legal requirements than matching funds, applicants must adhere to requirements for leveraged funds. Leveraged funds must be from non-federal sources and be committed within the grant timeframe. Moreover, if third-party organizations contribute to the leveraged funds requirement, then applicants must submit with their proposal package commitment letters from the third-party organizations confirming the amount of leveraging being committed. A pre-recorded webcast that presents information on applying for this funding opportunity can be found at FY26 Community Wood Pre-Application Webcast (Available by 2/20) Additional details on the funding opportunity can be found at Wood Innovations Homepage Instructions on how to apply for funding and the official application can be downloaded at the following weblinks: Instructions FY26 Community Wood Program Community Wood Grant Application (FS-1500-0051) Community Wood Grant Factsheet
2026 Wood Innovations Grant Funding Opportunity
The USDA Forest Service requests proposals to substantially expand and accelerate wood energy and wood products markets throughout the United States to support forest management needs on National Forest System and other forest lands. The grants and agreements awarded under this announcement will support the Agriculture Improvement Act of 2018 Pub. L. 115-334 Sec. 8643, Rural Revitalization Technologies 7 U.S.C. Sec. 6601, and Infrastructure Investment and Jobs Act Pub. L. 117-58 Div. J Title VI to meet the nationwide challenge of disposing of hazardous fuels and other wood residues from the National Forest System and other U.S. forest lands in a manner that supports wood products and wood energy markets. This Request for Proposals focuses on the following priorities to: 1.) Reduce wildfire risk and improve forest health on National Forest System and other forestlands; 2.) Reduce costs of forest management on all land types; 3.) Promote economic and environmental health of communities. The intent of the Wood Innovations Funding Opportunity is to stimulate, expand, and support wood products markets and wood energy markets. Projects can include, but are not limited to: Completing requirements, such as engineering designs, cost analyses, and permitting necessary, in the later stages of commercial construction projects that use wood as a primary building material and in the later stages of wood energy project development to secure financing. Early phase project development proposals will not be competitive. Developing manufacturing capacity, other necessary wood products infrastructure, and markets for wood products that support forest ecosystem restoration. Showcasing quantifiable environmental and economic benefits of using wood as a sustainable building material in an actual commercial building and the projected benefits achieved if replicated across the United States based on commercial construction market trends. Establishing statewide wood utilization teams and statewide wood energy teams. Only proposals from States without an existing (or former) team will be considered. Developing a cluster of wood energy projects in a geographic area or specific sector (e.g., prisons, hospitals, universities, manufacturing sector, or industrial sector). Overcoming market barriers and stimulating expansion of wood energy in the commercial sector. Additional details on the funding opportunity can be found at Wood Innovations Home page Instructions on how to apply for funding and the required Application Form can be downloaded at the following weblinks. **Note - Wood Innovations Application Form (FS-1500-50) has been corrected to address character/space limitations. Wood Innovations Funding Opportunity Application (FS-1500-0050) Instructions FY26 Wood Innovations Funding Opportunity Wood Innovations Application Webinar Wood Innovations Grant Factsheet Applications must be submitted in Grants.gov by 11:59 ET on April 22, 2026.
Ryan White HIV/AIDS Program Part C Capacity Development Program
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part C Capacity Development program is to strengthen organizational capacity to increase capacity to develop, enhance, or expand access to high quality HIV primary health care services for low-income people with HIV. The proposed activity should be of a short-term nature and should be completed by the end of the one-year funding opportunity period of performance. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Traumatic Brain Injury State Partnership
The purpose of this grant program is to improve the health and well-being of individuals with traumatic brain injuries (TBI) by streamlining access to critical resources, services, and supports for people who have sustained a TBI as well as leveraging resources for sustainability. Supported activities may include information and referral services for people with TBI and their caregivers, resource facilitation, outreach and awareness to communities about TBI, and brain injury screenings and trainings to community stakeholders and paraprofessionals. Funds may also support activities that promote comprehensive services and trainings for population with a higher prevalence of people impacted by brain injury, such as veterans, youth, individuals in the criminal legal system, and aging populations.
Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services. The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV , to directly remove barriers to care for the person with HIV, or to promote family stability. The purpose of this supplemental funding is to strengthen organizational capacity to respond to the changing health care landscape and increase access to high quality family-centered HIV primary health care services for low-income women, infants, children and youth (WICY) with HIV. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Project AWARE (Advancing Wellness and Resiliency in Education)
The purpose of Project AWARE is to develop a sustainable infrastructure for school-based mental health programs and services. Award recipients should build collaborative partnerships with the State Education Agency, Local Education Agency, Tribal Education Agency, the State Mental Health Agency, community-based providers of behavioral health care services, school personnel, community organizations, families, and school-aged youth.
Centers for AIDS Research (CFAR)
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for the Centers for AIDS Research (CFAR). The national network of CFARs cooperates with other HHS-funded HIV/AIDS programs to establish and maintain the collaborations and infrastructure required to carry out innovative implementation science research for ending the HIV epidemic domestically. Addressing a complex chronic disease, HIV/AIDS research requires broad scientific expertise, access to unique biological samples, and cutting-edge research technologies that extend beyond the needs of individual research groups. The CFAR program strengthens HIV/AIDS research by providing infrastructure that fosters multidisciplinary collaborations, maximizes efficiencies by reducing duplication of efforts, and leverages economies of scale to facilitate the translation of basic research findings into new HIV treatment, prevention, and cure approaches. A core mission of the CFAR program is to support and mentor early-career investigators and investigators new to HIV/AIDS research by funding pilot studies, emerging research opportunities, and high-risk/high-impact collaborative studies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Strengthening and modernizing Uganda's sustainable public health systems and workforce in data science, informatics, and surveillance to produce timely, accurate, and integrated data for action
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $30,000,000 for Year 1, subject to the availability of funds. This NOFO supports the Ministry of Health (MOH)-led digital transformation vision to modernize Uganda’s health data systems and infrastructure. It also supports enhancing capacity to provide timely epidemic intelligence for critical decision-making in HIV and related health programs. The data architecture is expected to encompass: General and targeted surveys.Clinical systems such as electronic medical records (EMR).Digital registers.Clinical indicator-based surveillance.Disease surveillance.Laboratory data.Commodities, logistics, and pharmacy management information systems.Community data.Human resource management and development.Other data collection activities to address existing data and knowledge gaps. The NOFO also supports developing digital solutions and strengthening data warehousing, integration, and interoperability to build a sustainable and resilient digital ecosystem ready for transition to local governance.
Sustaining life-saving HIV services in Ukraine by strengthening resilient health systems under the Ukraine Ministry of Health, Public Health Center
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $10,000,000 for Year 1, subject to the availability of funds. This NOFO aims to help the Public Health Center (PHC) of the Ministry of Health (MOH) enhance life-saving assistance for HIV and associated prevalent health conditions. This should be accomplished with targeted HIV testing, prevention, and treatment activities amid ongoing instability. The objectives of this NOFO include: Working to ensure that targeted HIV testing, treatment, retention, and prevention services are widely available for people who are at higher risk for HIV. Services should be provided in community settings using social network strategies (SNS). Activities include:Targeted community-based case finding.Immediate linkage to available treatment.Retention support.Management of advanced HIV disease and HIV/TB co-infection.Improving the availability of HIV services by mobile HIV testing, treatment, and prevention. You should use targeted mobile HIV case finding, treatment, retention, and prevention services. Activities include:Streamlining immediate linkage to treatment.Strengthening ongoing adherence support.Improving the availability and quality of HIV services at medical facilities by implementing differentiated service delivery (DSD) models. Activities include enhancing patients’ retention, adherence, and access to HIV services at the facility level.Enhancing essential, targeted HIV prevention service provision for people at higher risk for HIV, focusing on availability, quality, coverage and timely initiation.
Engaging faith-based organizations to sustain lifesaving HIV and TB services in Ethiopia
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $5,000,000 for Year 1, subject to the availability of funds. This NOFO will engage faith-based organizations (FBOs) to support and sustain lifesaving HIV, TB, and cervical cancer services in Ethiopia. HIV services will include: • HIV testing. • HIV prevention, including vertical transmission. • Adult and pediatric HIV care and treatment. Through this project, you will work with faith communities to provide and link people with lifesaving HIV services. You will serve: • People at high risk of acquiring HIV. • Undiagnosed people living with HIV • People living with HIV at risk of interrupting their treatment. • Pregnant and breastfeeding women. • People living with HIV who may face barriers to accessing conventional health facility services. You will be expected to implement cost-efficient models and integrate them with the routine health-care delivery system to reach undiagnosed people living with HIV, people living with HIV who have defaulted from care, and people at high risk of acquiring HIV, ensuring their access to critical, lifesaving HIV and TB services. This NOFO will support activities that promote country ownership and country-led plans that enable greater sustainability. Programs supporting other public health threats and emergencies in Ethiopia may also be included in this NOFO.
Strengthening Botswana's national data, performance management, and surveillance systems for a sustainable and government-led HIV, TB, and related public health response
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $4,000,000 for Year 1, subject to the availability of funds. This NOFO aims to provide targeted strategic assistance to the Government of Botswana (GOB) to strengthen health security and national data systems. It focuses on: Governance and policies.Capacity building to sustainably manage data.System functionality, interoperability, and data use.You are expected to support the GOB to help ensure that comprehensive, quality HIV-related strategic information and health security systems operate effectively at the site, district, and national levels. Your activities should include: Transferring skills and management of technology systems to GOB so it can operate, maintain, and use current facility, community, and national data systems. These systems include any paper and electronic record systems necessary to manage patients and monitor programs that deliver lifesaving HIV and TB care, treatment, and targeted prevention services.Transferring skills and technology related to existing country data systems to GOB. This includes systems that ensure routine program monitoring, oversight, compliance, and reporting. This also includes enhancing workforce knowledge and skills to operate, maintain, and secure the systems and analyze data.Strengthen the health security capacities of the GOB and relevant interest holders to surveil, respond to, and control public health events and disease outbreaks across all administrative levels.
Improving regional capacity to respond to HIV, TB, and other global health priorities in Central America
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $20,000,000 for Year 1, subject to the availability of funds. You will advance progress towards achieving the 95-95-95 targets and continue to transition site-level support to local governments in Central America (CA) for: El Salvador.Guatemala.Honduras.Nicaragua.Panama.To achieve the goals of this NOFO, you will address gaps in: HIV prevention.Diagnosis.Life-saving treatment.Proposed activities should facilitate country ownership while improving local capacity to: Make sure HIV prevention is available for populations most at risk, through the Sentinel Surveillance of STI and HIV Strategy (VICITS).Provide testing that leads to active linkage to HIV treatment and prevention services.Improve early HIV diagnosis through active case-finding strategies, including:Testing as outreach for populations most at risk for HIV.Index, provider-initiated, and community testing.Social network strategy.Self-testing.Support the integration of comprehensive care and treatment services, including for HIV, TB, and other opportunistic infections.Build capacity of healthcare workers to provide high-quality health services led by the country, and through continuous quality improvement (CQI) initiatives.Make sure adequate data systems are used to monitor progress toward 95-95-95 targets and other global health priorities.Support sustainable health systems that improve:Efficiency.Country ownership of the program.Global health security to fight priority infectious diseases and other public health threats.
Building National Partnerships for the Prevention of Emerging and Reemerging Infectious Diseases
This cooperative agreement establishes a single, integrated funding mechanism aimed at enhancing the nation's ability to prevent, detect, and respond to infectious disease threats. It will support clinicians, healthcare professionals, healthcare systems, institutions, and organizations directly involved in patient care, public health, and infectious disease control across the United States. By strengthening the capacity of these key stakeholders, the program will enable more effective frontline engagement, facilitate the implementation of timely public health responses, and generate expert insights to inform and improve public health guidance and practice. The program will focus on building and sustaining critical infrastructure, workforce training, communication strategies, and emergency response capabilities needed to address both emerging and reemerging infectious diseases. Emphasis will be placed on expanding national infection prevention capacity through targeted education and training initiatives, particularly in the areas of antimicrobial resistance and infection control. Additionally, the program will enhance preparedness by supporting surge staffing and fostering coordination among healthcare and public health partners during emergency response efforts.
A Demonstration to Scale Innovative Person-Centered Approaches to Falls Prevention through Clinical-Community Partnerships
The purpose of this funding announcement is to demonstrate and evaluate the scalability of person-centered and evidence-based approaches to falls prevention that leverage clinical and community partnerships and related data and technology tools. ACL intends to award a single cooperative agreement to one grantee for a three-year project period with the expectation that the grantee will fund up to three demonstrations. This award will build on the ACL Innovation Lab to demonstrate the scaling of person-centered and evidence-based approaches to falls prevention and related chronic disease management programs through community care hubs and their respective clinical partners and community-based organizations in the aging services network. The successful applicant will be expected to collaborate with ACL in the design and implementation of these demonstrations in the scalability of falls prevention and related chronic disease management interventions through approximately three advanced community care hubs that support care transitions and screening for the risk of falls. They should also have the capacity to 1) do rapid cycle evaluation to iterate and improve the impact of the interventions as they are scaled and, 2) administer sub-awards to community care hubs that can implement and scale person-centered interventions enabled by artificial intelligence, data analytics, assistive technology, virtual delivery of interventions, tools to support consumer behaviors, and related data infrastructure.
Lifespan Respite Care Program: Grants to New States and States Re-Establishing Their Core Respite Infrastructures
ACL is seeking applications from eligible state agencies that will establish, or reestablish, state and local coordinated Lifespan Respite Care systems and deliver respite care and related services to family caregivers of children and adults across all age groups, disabilities, and chronic conditions as defined in the statute. Funds supplement, not replace existing funds. Eligible states applying must fall within one of the following two categories: 1) New States that have not previously received a grant under this program. 2) Returning States who have had at least one (1) Lifespan Respite Care Program grant, but whose programs have gone dormant or lapsed since federal funding ended, and desire to re-establish their core state respite infrastructures, rather than apply for a Program Enhancement grant. ACL will fund approximately four (4) cooperative agreements for the 3-year project period. All programs must, from the outset, address the respite needs of all populations regardless of age, disability, or chronic condition of the care recipient population. Funded applicants shall use grant funds to serve all age groups and disabilities, provide new and emergency care services, recruit and train workers and volunteers, help families access care services and other authorized services as outlined in the Act. It is ACL’s expectation that all grantees will, no later than the second and third years of the grant project period, provide respite services while continuing to build their statewide respite infrastructure. Awardees under this funding opportunity will work with ACL to implement the data collection and reporting requirements under Section 2904 of the Lifespan Respite Reauthorization Act of 2020.
Advancing Whole-Person Health: Enhancing Networks of Community-Based Aging and Disability Organizations to Improve Access to Long-Term Services and Supports
ACL intends to award a single cooperative agreement to one grantee for a three-year project period. This award will support a regional community care hub (CCH) scaling strategy to expand access to long-term services and supports (LTSS) for older adults and people with disabilities as part of a broader No Wrong Door System effort. The successful applicant will be expected to collaborate with ACL to support approximately three regional advanced CCHs to enable CCH scaling through shared infrastructure services and alignment with existing CCHs and other community-based aging and disability organizations. They should also have the capacity to provide technical assistance to the selected super hubs as they work to expand their infrastructure capacity to support streamlined access to LTSS through health care payer partnerships, with services inclusive of care transitions, care coordination, and evidence-based prevention/health promotion programs.
Expanding Global Health Security through local partnerships in Senegal
This NOFO aims to enhance Senegal's public health infrastructure to prevent, detect, and respond to infectious disease threats through implementing partners. The initiative focuses on strengthening public health surveillance systems, including community-based surveillance, improving laboratory networks, and enhancing workforce training. The goal is to build sustainable, resilient health security infrastructure, aligning with Global Health Security Agenda (GHSA) objectives. Partners will collaborate to promote cross-sectoral coordination and foster innovative approaches.
Centers for Independent Living Competition - Guam
ACL intends to award funds for the establishment of one (1) center for independent living in Guam to provide, expand and improve the provision of independent living services and support the network of centers for independent living. At a minimum, centers funded by the program are required to provide the following core services: information and referral; independent living skills training; peer counseling; individual and systems advocacy; and services that facilitate transition from nursing homes and other institutions to the community, assistance to those at risk of entering institutions and facilitate the transition of youth to postsecondary life. The estimated total funding amount to be awarded to establish a center for independent living in Guam is $159,762. Twenty-four-month project period with two 12-month budget periods.
Centers for Independent Living Competition - American Samoa
ACL intends to award funds for the establishment of one (1) center for independent living in American Samoa to provide, expand and improve the provision of independent living services and support the network of centers for independent living. At a minimum, centers funded are required to provide the following core services: information and referral; independent living skills training; peer counseling; individual and systems advocacy; and services that facilitate transition from nursing homes and other institutions to the community, assistance to those at risk of entering institutions and facilitate the transition of youth to postsecondary life. The estimated total funding amount to be awarded to establish a center for independent living in American Samoa is $159,762. Twenty-four-month project period with two 12-month budget periods.
Novel approaches to support therapeutic development in ultra-rare cancers
The purpose of this program is to support new approaches that can be applied to facilitate therapeutic development in ultra-rare pediatric and adult cancers, including molecularly-defined subsets of more common cancers. Specific areas of interest include, but are not limited to, the following examples: • Development of infrastructure for a coordination network and data repository for patient-level data across institutions and internationally to support drug development and regulatory decision-making for one or more ultra-rare cancers. • Investigations to explore opportunities to develop and validate early clinical endpoints and other novel efficacy endpoints for evaluation of treatments for ultra-rare cancers. • Development and implementation of a collaborative multi-stakeholder effort to support generation and use of real-world data leveraging a registry framework for use in development of new therapies for pediatric patients with diffuse midline glioma (DMG) (including diffuse intrinsic pontine glioma, DIPG). • Innovative approaches to identify new biologically-driven opportunities for clinical development of previously approved drugs or biologics (hereafter referred to as drugs), including drugs for which development has been discontinued, in ultra-rare cancers. • Research to develop novel approaches to preserve the availability of drugs for which commercial developers have discontinued adult development that have strong potential in ultra-rare cancers but lack financial incentives for commercial development • Development of methods to incorporate use of telemedicine and/or pragmatic trial design elements (e.g., collecting laboratory and/or imaging data from local facilities) for patient assessments to facilitate enrollment of patients with ultra-rare cancers • Development of nanoparticle-based delivery approaches for therapeutic nucleic acids targeting onco-fusion transcription factors in metastatic tumor animal models using targeted bioPROTAC degradation or genomic editing strategies. Successful efforts should demonstrate effective delivery and expression in-vivo to tumor cells, and downregulation of the target transcription factor protein while minimizing off-target effects and limiting sequestration of the nanoparticle by the liver, spleen, and lungs. • Research to exhaustively characterize the plasma-membrane protein expression (surfaceome) of an ultra-rare cancer and the presumed healthy tissue of origin, as well as the resident-tissue stem cells, by single-cell transcriptomics and proteomics. These studies, and available correlative database analyses, should be designed to identify possible combinatorial signatures of plasma membrane proteins unique to the ultra-rare tumor. Tumors of interest include Sclerosing epithelioid fibrosarcoma and atypical teratoid rhabdoid tumors (ATRT).
HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems
Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers. Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.
Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with other NIH Institutes and Centers (ICs) - National Eye Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Deafness and Other Communication Disorders, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, and National Cancer Institute - intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the establishment and continuation of Genomic Curation Expert Panels that manually curate, review and define the clinical relevance of genes and variants as part of the NIH established and funded Clinical Genome Resource (ClinGen). Despite advances in genomic sequencing technology and increasing adoption in clinical practice, there are many genomic variants with unknown significance (VUS), and there is limited understanding of their function. This presents barriers to genomic and precision medicine. To address this need for better knowledge about the links between genes, variants, and disease, this NOFO will facilitate the development of Expert Panels to select genes and variants associated with diseases or conditions of high priority for participating NIH Institutes and Centers (ICs) and to systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions. The Expert Panels funded through this NOFO are required to utilize the NHGRI ClinGen and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure. Ultimately, these expert panels contribute to an authoritative, centralized, and public resource, through aggregation, evaluation, and sharing of expert-curated data about genetic conditions, and the variants that cause them.
HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
The National Institute on Drug Abuse (NIDA), with other NIH Institutes, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to support action-oriented research that accelerates the translation of addiction epidemiology, prevention, treatment, and recovery research to practice addressing both the opioid crisis and overdose events. Research supported under this initiative would focus on identifying and characterizing malleable factors and addressing barriers or facilitators to reducing substance use, misuse and overdose deaths at the individual, provider, organizational, community, or system levels. The emphasis would be on exploring and developing effective, replicable, and scalable approaches for accelerating the movement of evidence-based and promising treatments and preventive interventions into routine use. Specific priority areas would include, but not be limited to: recovery, prevention, pain/addiction intersections, engaging family and loved ones, transitions across care settings (e.g., inpatient treatment to community treatment), mental health integration, improving quality and efficiency of existing services and interventions, examining substance use and health outcomes and meaningful real-time data capture and use to improve services and public health approaches to reducing substance use, misuse, addiction, and overdose. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R61/R33 activity code. Investigators with expertise and insights into this area of addiction epidemiology, prevention, treatment, recovery and health services research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in modeling, health economics, implementation science, translation, or engagement science will be encouraged, and these investigators should also begin considering applying for this application.
HIV Prevention and Alcohol (R01 Clinical Trials Optional)
The NOFO seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. This includes integration of effective prevention and treatment interventions with an understanding of the overarching framework for reducing the incidence of new infections by facilitating cross-cutting informative research. This research activity includes the development and testing of new interventions and expansion of existing effective interventions as well as the implementation of these integrative preventive activities in a variety of settings and populations. Six areas of research are of primary interest related to alcohol use and related mental health and substance use comorbidities. These include but are not limited to 1) PrEP Utilization, 2) Treatment as Prevention (TasP), 3) Integration of Preventive Intervention Strategies, 4) Prevention-related Cross-cutting Research, 5) Syndemic Approaches and, 6) Implementation and Operations Research.
GPD Grant Forecast
THIS IS NOT A NOTICE OF FUNDING. THIS IS A GENERAL FORECAST ONLY. Grant and Per Diem (GPD) Program Introduction The GPD Program is VA’s largest transitional housing program for Veterans experiencing homelessness and is permanently authorized under Public Law 109-461. Since 1994, the GPD Program has awarded grants to community-based organizations to provide transitional housing with wraparound supportive services to assist vulnerable Veterans move into permanent housing. The grants are designed to meet Veterans at various stages as they move to stable housing. Community-based organizations receiving GPD grants offer focused transitional housing services through a variety of housing models targeted to different populations and needs of Veterans. The GPD program plays a vital role in the continuum of homeless services by providing supportive services to those Veterans who would otherwise be among the unsheltered homeless population. The result of GPD programs is that Veterans achieve residential stability, increase their skill levels and/or income, and obtain greater self-determination. Types of GPD Grants Transitional housing grants: Per Diem Only (PDO) grants provide funding in the form of per diem payments to reimburse grantees for the cost of care provided to Veterans in transitional supportive housing. Special Need grants target housing and services to specific populations of Veterans (e.g., women, Veterans with chronic mental illness, frail elderly Veterans, Veterans caring for minor dependents, terminally ill Veterans). Transition-In-Place (TIP) grants offer Veteran residents housing in which supportive services transition out of the residence over time, rather than the resident. Upon completion of the TIP services, the resident retains the unit as their permanent housing with no requirement to move. Other types of grants: Case Management grants support Veterans who were previously experiencing homelessness or who are at risk for homelessness so that they may obtain or retain permanent housing. Capital grants support the costs of acquiring, renovating, or constructing facilities and are only offered intermittently to improve existing facilities or to develop new transitional housing depending on VA's priorities and funding availability. Lists of current grantees are available on the GPD website. How to Apply for GPD Funding Not all grant types are available annually. When available, notices of funding can be found at the following locations: www.grants.gov and https://www.va.gov/homeless/gpd.asp. Application instructions are provided in each notice of funding. Each notice of funding will clarify specific eligibility criteria, application requirements, funding limitations, and other requirements. Applications are submitted through an online portal that is only available when there is an open notice of funding. Potential applicants who wish to see what was required for previous applications may review past notices of funding, available on the GPD provider website and www.grants.gov. Past notices of funding are not a guarantee of future requirements. Tentative Estimated GPD Award Schedule Specific dates are not able to be forecast. The follow tentative approximations are provided for general planning purposes. FY 2026 Case Management – GPD tentatively expects to offer a notice of funding around FY 2025 for case management awards starting approximately in FY 2026. FY 2027 PDO – GPD tentatively expects to offer a notice of funding around FY 2026 for PDO awards starting approximately in FY 2027. TIP – GPD tentatively expects to offer a notice of funding around FY 2026 for TIP awards starting approximately in FY 2027. FY 2028 GPD tentatively does not expect to offer a notice of funding for this timeframe. GPD may update this forecast closer to the time. THIS IS NOT A NOTICE OF FUNDING. THIS IS A GENERAL FORECAST ONLY.
Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed
The intended outcome of this Notice of Funding Opportunity (NOFO) is to advance efforts for a nationally Integrated Food Safety System (IFSS) by supporting Manufactured Food Regulatory Program Standards (MFRPS), Food Protection Task Force (FPTF) programs, Dietary Supplement (DS) programs, and special projects. For the purposes of this NOFO, the term state encompasses all eligible organizations as defined in Section 3. MFRPS Development or Maintenance: The purpose of this Notice of Funding Opportunity (NOFO) section is to advance efforts for a nationally Integrated Food Safety System (IFSS) by assisting state manufactured food regulatory programs to achieve and maintain conformance with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS). The MFRPS are intended to ensure that state manufactured food regulatory programs implement a high-quality regulatory program through the development and maintenance of a regulatory framework that builds on and emphasizes mutual reliance with all programs. Also, the program standards are intended to enhance food safety by establishing a uniform basis for measuring and improving the performance of manufactured food regulatory programs in the United States. Conformance with these program standards will help federal and state programs better direct their regulatory activities at reducing foodborne illness hazards in plants that manufacture, process, pack, or hold foods. Food Protection Task Force (FPTF): The purpose of this funding option is to establish and/or support a Food Protection Task Force (FPTF) with diverse membership representative of stakeholders across the state that is responsible for promoting the integration of an efficient statewide human and animal food (HAF) protection system that addresses state and region-specific needs and that maximize the protection of the public health. These efforts include: establishing a food safety/protection network of subject matter experts, fostering educational opportunities, developing replicable resources and systematically fostering communication, education, outreach, cooperation and collaboration within the states among federal, state, local, tribal and territorial HAF protection, public health, agriculture, and regulatory agencies, industry, academia, and consumers to initiate and/or support HAF protection activities to improve public health. A strong FPTF can also help improve human and animal food emergency surveillance, response, and post-response systems by focusing on preparedness, building strong communication channels, and establishing relationships with key players before food-related incidents occur. Dietary Supplements: The goal of this funding option is to facilitate the development of state driven dietary supplement regulatory framework and programs. The overall objective of this funding opportunity is to advance the adoption and implementation of the cGMPs for Dietary Supplements Rule codified at 21 CFR Part 111. Specifically, this track will provide funding support for dietary supplement training and program development activities. Special Projects: The purpose of this funding option is to develop and implement special projects that support innovation and integration in a IFSS using the MFRPS framework. This track will support other emerging food safety priorities that develop over the lifespan of the project. State programs will be expected to share project deliverables and resources developed with other programs.
Identification of Drug-related and Formulation-Related Factors that Result in Alcohol Dose Dumping of Modified Release Oral Drug Products (U01) Clinical Trial Not Allowed
Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.
NHLBI Program Project Applications (P01 Clinical Trials Optional)
The National Heart, Lung, and Blood Institute (NHLBI) Program Project Grant (P01) supports research related to fundamental processes and diseases of the heart, blood and lymphatic vessels, lungs, and blood, including transfusion medicine, blood resources, and sleep disorders other programs including implementation science, health disparities, and translation research that address the mission of the Institute. This FOA requires a minimum of three interrelated research projects that investigate a complex biomedical theme or research question. The projects may be supported by core units, if justified, to facilitate economy of effort, space, and equipment. The NHLBI provides support for Program Project Grants (PPGs) in the belief that collaborative research efforts can accelerate the acquisition of knowledge more effectively than a simple aggregate of research projects that have no interaction or thematic integration. NHLBI is particularly interested in encouraging new scientific directions in PPGs. Use of the P01 activity code is viewed as an opportunity to attract scientists who have not traditionally been supported by the NHLBI. Further, the PPG environment presents an opportunity for emerging scientific leaders to gain insight into how to lead a successful scientific Program, and applicants will have the opportunity to include a project led by an Early Stage Investigator (ESI). All projects in the Program must be interrelated and have objectives that address a central theme within the scientific mandate of the NHLBI.
State Veterans Home Construction Grant Program
Improving Oversight of Federal GrantmakingVA is required to ensure compliance with all applicable statutes, regulations, and Executive Orders when evaluating and awarding grants. In accordance with Executive Order 14332, Improving Oversight of Federal Grantmaking, aside from the evaluation criteria published in this announcement, VA has discretion to remove from consideration any applicant VA deems does not clearly advance the President's or VA's priorities. VA will not fund activities that use racial preference for eligibility criteria or promote gender ideology. VA will not fund activities that promote or facilitate violations of immigration laws or are sources of waste, fraud, or abuse. VA will not tolerate activity or conduct by grant recipients that constitute acts of moral turpitude, are scandalous, or bring the recipient, the project funded by this grant, or VA into public disrepute, contempt, or ridicule. These grants support the President's priority to increase the excellence of and options for care, benefits, and services for veterans, as demonstrated in Executive Order 14332. Program is subject to Public Law 117-58 Build America, Buy America Act. Recipients of an award of Federal financial assistance from a program for infrastructure are hereby notified that none of the funds provided under this award may be used for a project for infrastructure unless:(1) all iron and steel used in the project are produced in the United States--this means all manufacturing processes, from the initial melting stage through the application of coatings, occurred in the United States; (2) all manufactured products used in the project are produced in the United States—this means the manufactured product was manufactured in the United States; and the cost of the components of the manufactured product that are mined, produced, or manufactured in the United States is greater than 55 percent of the total cost of all components of the manufactured product, unless another standard for determining the minimum amount of domestic content of the manufactured product has been established under applicable law or regulation; and (3) all construction materials44 are manufactured in the United States—this means that all manufacturing processes for the construction material occurred in the United States. The Buy America preference only applies to articles, materials, and supplies that are consumed in, incorporated into, or affixed to an infrastructure project. As such, it does not apply to tools, equipment, and supplies, such as temporary scaffolding, brought to the construction site and removed at or before the completion of the infrastructure project. Nor does a Buy America preference apply to equipment and furnishings, such as movable chairs, desks, and portable computer equipment, that are used at or within the finished infrastructure project, but are not an integral part of the structure or permanently affixed to the infrastructure project. Grants are available to State and Tribal Governments for construction or renovations of State/Tribal owned and operated Veterans Extended Care Facilities. The Department of Veterans Affairs participation may not exceed 65% of the total project costs. Review governing regulation before submitting an application (38 CFR Part 59). If the state is submitting a new grant application, it must submit a complete initial application (Section A of the project checklist) on Grants.gov by April 15th in order to be eligible for listing on the Priority List for the next fiscal year. Once the complete initial application is retrieved from Grants.gov by Program Staff, the grant applicant will receive 1) an automated notification from Grants.gov confirming receipt by the Program and 2) an email from Program Staff indicating the application's FAI number and corresponding project page in MAX.gov for submission of subsequent items. Note that Grants.gov is used only once to submit a new grant application. Applicants must submit complete initial applications on Grants.gov in order to be considered. Please contact Program Staff prior to submission if you need assistance understanding the requirements pertaining to an initial grant application, or if you need general assistance. Renovation or Life Safety initial grant applications require items A.1.-A.7. in Section A of the project checklist. Grant applicants, do not submit items A.8.-.A.13 for Renovation of Life Safety grants. Adult Day Health Care, New Home Construction or Bed Replacement initial grant applications require all items in Section A (A.1.-A.13) of the project checklist. Required for ALL applications A.1.A Project Scope A.1.B Form SF424 A.1.C Form SF424D A.1.D Form SF424C A.1.E Budget Justification Worksheet (must align with SF424C budget form) A.2. Governor's designation of authorized state official and contact person A.3. Needs assessment (as outlined in VA Form 10-0388-1) A.4. State Clearinghouse Comments (E.O. 12372) single point of contact and compliance statement A.5. Schematics A.6. Signed Initial Application Certification VA Form 10-0388-1 A.7. Safety citation/letter (Only Life Safety projects need to submit this). Required for Adult Day Health Care, Bed Replacement or New Construction - Items A1-A6 and the below items A.8. Space program analysis (NHC use Form 10-0388-3, ADHC use Form 10-0388-4) A.9. Five-year capital plan for state's entire state home program A.10. Financial plan for state facility's first three years of operation A.11. Documentation that there is a reasonable basis to conclude that the facility when complete will be fully occupied A.12. Authorized state official's certification of the total number of state-operated nursing home and domiciliary beds and occupancy rate A.13. Authorized state official's certification that the number of state home beds does not exceed the requirement in 38 CFR 59.40 or justification for number of state home beds exceeding 38 CFR 59.40 based on travel distance