Oral Health
Dental care and oral health programs for underserved populations.
Screening, Brief Intervention and Referral to Treatment
The purpose of this program is to implement the Screening, Brief Intervention, and Referral to Treatment public health model for children, adolescents, and/or adults in primary care and community health settings (e.g., health centers, hospital systems, HMOs, PPOs, health plans, FQHCs, behavioral health centers, pediatric health care providers offices, children’s hospitals) and schools, with a focus on screening for underage drinking, opioid use, and other substance use.
Center of Excellence for Protected Health Information Related to Behavioral Health
The purpose of this program is to implement a National Center of Excellence to develop and disseminate training, technical assistance, and educational resources for healthcare practitioners, families, individuals, states, and communities on federal privacy statutes and regulations as they relate to behavioral health data.
Behavioral Health Partnerships for Early Diversion of Adults and Youth
The purpose of this program is to develop and implement infrastructure that supports programs that divert adults and/or youth with a mental illness or a co-occurring substance use disorder from the criminal and/or juvenile justice systems prior to arrest and booking.
Promoting Integration of Primary and Behavioral Health Care: States
The purpose of this program is to: promote full integration and collaboration in clinical practices between physical and behavioral health care; support the improvement of integrated care models for physical and behavioral health care to improve overall wellness and physical health status; and promote the implementation and improvement of bidirectional integrated care services, including evidence-based or evidence-informed screening, assessment, diagnosis, prevention, treatment, and recovery services for mental and substance use disorders, and co-occurring physical health conditions and chronic diseases.
Behavioral Health Mobile Crisis Team Partnerships
The purpose of this program is to establish new, or enhance existing, mobile crisis teams that serve children, youth, and adults experiencing mental health or substance use crises. Its focus is the expansion of behavioral health crisis response capacity and the development of structured partnerships that reduce reliance on law enforcement and emergency departments for behavioral health crises.
Public Health Strategies to Address Alzheimer's Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator
Alzheimer's disease, the most common form of dementia, is a progressive condition. It begins with mild memory loss and may lead to the inability to communicate or respond to one's environment. Its prevalence is rising with the aging U.S. population. In 2021, it was the 5th leading cause of death for those 65 and older, with death rates continuing to climb. The CDC Alzheimer's Disease Program, through the National Healthy Brain Initiative (HBI) and funded partners, promotes brain health, addresses cognitive impairment, and supports caregivers using evidence-based approaches. This funding opportunity aligns with the HBI Road Map Series (including the State and Local Road Map 2023–2027 and the Road Map for Indian Country) and fulfills the aims of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406). Funding Structure: Component 1: National Healthy Brain Initiative: Funds up to two (2) organizations to develop and implement public health strategies guided by the HBI Road Map Series. Funded organizations will: Develop evidence-informed training for health care and public health professionals on ADRD and caregiving. Expand the availability and use of public health surveillance data, including adaptation & revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline and caregiver optional modules. Facilitate the coordination of recipients and national partners to address ADRD. Funding range: $2,500,000 to $3,000,000 per 12-month budget period. Component 2: BOLD Public Health Centers of Excellence: Funds three (3) Centers, each specializing in one of three topic-specific areas: dementia risk reduction, early detection and management of dementia, or dementia caregiving. Centers will: Support the needs of the BOLD public health program and other public health agencies. Identify, disseminate, and promote best practices. Translate promising research into practical tools and resources. Increase professional education and develop materials to address specific individual needs to improve health outcomes. Funding range: $750,000 to $1,000,000 per 12-month budget period. Component 3: ADRD Public Health Adoption Accelerator. Funds up to two (2) organizations to serve as public health strategy adaptation accelerator programs. This means using dissemination and implementation of science to spread and put into practice effective public health strategies, tools, and resources to tackle ADRD. Organizations will: Collaborate with CDC and other organizations to create a prioritized list of ADRD approaches & strategies. Use proven strategies to engage partners, health care organizations, and policymakers to enhance uptake and implementation, accelerating the impact of ADRD efforts. Provide technical assistance to Component 1 & 2 recipients. Funding range: $750,000 - $1,200,000 per 12-month budget period. Applicants may apply for multiple components, but must submit a separate application per component.
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close gaps in health outcomes within the US population and increase health for all.Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, participant recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination. The application should also describe its approaches to increase community engagement from conceptual design of the intervention through implementation and sustainability, close gaps in health outcomes within the US population, and increase health for all.
BJA FY25 Veterans Treatment Court Program
This NOFO will support the implementation and enhancement of veterans treatment court (VTC) operations. VTCs connect justice-involved veterans to treatment for substance use disorders (SUD), mental health disorders (MHD), co-occurring mental health and substance use disorders (MHSUD), post-traumatic stress disorder (PTSD), and traumatic brain injury (TBI). Funding supports service coordination, and recovery support services. VTCs integrate mandatory drug testing, incentives and sanctions, and transitional services in judicially supervised criminal court settings that have jurisdiction over veterans with behavioral health treatment needs. These courts aim to reduce recidivism and overdose fatalities, while increasing access to treatment and recovery support that leads to long-term recovery.
Ryan White HIV/AIDS Program Part F Dental Reimbursement Program
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part F Dental Reimbursement Program (DRP) is to improve access to oral health care services for low-income people with HIV, and related education and training to dental providers serving people with HIV. Authorized under section 2692(b) of the Public Health Service Act (42 U.S.C. § 300ff–111(b)), the DRP provides partial reimbursement to eligible dental schools and accredited dental hygiene programs for the unreimbursed costs of oral health care provided to patients with HIV. Eligible institutions may annually apply for reimbursement based on costs incurred in the prior year. Available funds are distributed among all eligible applicants, taking into account the number of patients with HIV served and the extent of unreimbursed care costs relative to other applicants.
Regional Pediatric Prevention Network
The purpose of this program is to support a Regional Pediatric Prevention Network (RPPN). The RPPN strengthens local and regional capacity to care for children during disasters and emergencies through community partnerships, coordinated pediatric preparedness, and dissemination of research-informed pediatric disaster care. The RPPN will include at least 10 children’s hospitals, or their university pediatric partners, funded through two primary awards. It will also include community partners working with these hospitals. Each of the 10 Children’s Hospital centers will advance pediatric emergency and disaster preparedness at the local, regional, and national levels, including for children with special health care needs and behavioral health concerns, children living in poverty, and children in rural, remote, and tribal areas.
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit research applications for practice-based research centers to support interdisciplinary teams of mental health researchers to engage in high-impact studies that will significantly advance clinical practice and generate knowledge to fuel the transformation of mental health care in the United States. Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers support research projects aimed at the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders; (2) developing and testing empirically informed patient-, provider- and system-level interventions to improve mental health care access, engagement, continuity, efficiency, and quality; and (3) continuously improving the quality, impact, and durability of optimized interventions and health for individuals with or at risk for mental health problems, including those with serious mental illness. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive research projects. This NOFO will utilize the P50 activity code. Applications must propose research that maximizes synergies across various components of the mental health research ecosystem, including new discoveries in clinical research, transformative health care technologies, advances in information science, and new federal and state mechanisms for organizing mental health care. Applicants with interdisciplinary expertise, such as behavioral science, health information and data science, health systems engineering, decision science, implementation science, and related fields, whose practice-based research needs cannot be met through standard research project grant mechanisms, should consider applying to this NOFO. Applications are also expected to include research activities that facilitate the widespread sharing of data, methods, and resources to accelerate clinical research and to provide opportunities for graduate students, postdoctoral researchers, and early-career investigators to participate in interdisciplinary research-to-practice translational mental health research.
Primary Care Dental Faculty Development Center Program (PCDFD)
The Primary Care Dental Faculty Development Center serves as a resource and training hub to: Support the development of faculty who teach primary care dentistry. Advance community and population-level approaches to assess and improve oral health outcomes. Prepare dental faculty for roles in program leadership. Faculty development will include: increasing the ability to teach clinical dentistry, developing leadership competencies, and dissemination including publishing and presentations.
Dental Faculty Loan Repayment Program (DFLRP)
The purpose of the Dental Faculty Loan Repayment Program is to increase the number of dental and dental hygiene faculty in the workforce by assisting dental and dental hygiene training programs to attract and retain full-time faculty through loan repayment.
Delta Rural Integrated Health Network Program
The Delta Rural Integrated Health Network Program seeks to improve healthcare delivery in the region by supporting the development of integrated health networks among rural hospitals, primary care clinics, behavioral health providers and other essential services.
Agriculture and Food Research Initiative Competitive Grants Program Education and Workforce Development
The Agriculture and Food Research Initiative - Education and Workforce Development (EWD) focuses on developing the next generation of research, education, and extension professionals in the food and agricultural sciences. The National Institute of Food and Agriculture (NIFA) requests applications for the AFRI’s Education and Workforce Development program areas to support: 1. professional development opportunities for K-14 educational professionals; 2. non-formal education that cultivates food and agricultural interest in youth; 3. workforce training at community, junior, and technical colleges; 4. training of undergraduate students in research and extension; 5. fellowships for predoctoral candidates; 6. fellowships for postdoctoral scholars; and 7. education and workforce development workshop grants.
Providers Clinical Support System – Substance Use Disorder Treatment (PCSS-SUD Treatment)
The purpose of this program is to provide training and technical assistance (TTA), mentoring, and ongoing support for healthcare professionals in general health and behavioral health settings to increase their capacity to identify and treat substance use disorders (SUDs), especially opioid and alcohol use disorders.
Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY) Existing Geographic Service Areas
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services). The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV, to directly remove barriers to care for the person with HIV, or to promote family stability.
Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services. The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV , to directly remove barriers to care for the person with HIV, or to promote family stability. The purpose of this supplemental funding is to strengthen organizational capacity to respond to the changing health care landscape and increase access to high quality family-centered HIV primary health care services for low-income women, infants, children and youth (WICY) with HIV. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Rural Communities Opioid Response Program (RCORP)-Planning
Rural Communities Opioid Response Program (RCORP)-Planning supports organizations in rural communities to build the partnerships and foundational capacity needed to develop, implement and sustain a comprehensive system of substance use disorder (SUD) and related services. RCORP’s focus is on opioid misuse and its impact on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Individuals struggling with SUD, including opioid use disorder (OUD), need a continuum of mental, behavioral, and related social supports. RCORP-Planning helps address these needs in a comprehensive way. This program is intended for rural communities that may find the logistics or requirements of larger, more complex federal grant programs to be barriers to accessing start-up support. Funding will serve as a critical first step to creating SUD service systems that make care easy to access, strengthen the behavioral health workforce, and have strong community buy-in. It will help prepare communities to provide sustainable prevention, treatment, recovery, and other supportive services that: reduce substance use initiation and misuse,address the mental, behavioral, and psychosocial needs of people who use illicit substances or misuse alcohol, or are in recovery from substance use problems, andreduce disease and death related to substance use problems, including OUD, in high-risk rural communities.The intent of this program is to fund planning activities only. Funds may not be used for direct service delivery.
Rural Communities Opioid Response Program (RCORP)-Impact
The Rural Communities Opioid Response Program (RCORP)–Impact funds rural communities to drive measurable improvements in access to integrated, coordinated treatment and recovery services for substance use disorder (SUD), including opioid use disorder (OUD). Its long-term aim is to reduce morbidity and mortality associated with SUD and enable sustained recovery and well-being. The program supports: New or expanded evidence-based SUD prevention, treatment, and recovery services in rural areas;Coordination across health and supportive social services to enable sustained, long-term recovery;A larger, more responsive workforce to address SUD-related needs; andMulti-sector community networks to strengthen and sustain local service delivery.The focus of RCORP-Impact is on reducing the impact of opioid misuse on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Therefore, RCORP-Impact supports a comprehensive approach to address all SUD, including OUD, within a continuum of mental, behavioral, and related social supports.
Fiscal Year (FY) 2026 Quality Improvement Fund - Improving Access to Dental Services for Children with Neurodevelopmental Disorders (QIF-DNDD)
The purpose of fiscal year (FY) 2026 Quality Improvement Fund: Improving Access to Dental Services for Children with Neurodevelopmental Disorders (QIF-DNDD) is to increase access to preventive dental and additional dental services and improve dental health outcomes for children with neurodevelopmental disorders (NDDs), including children with autism spectrum and developmental disorders. Through this one-time investment, health centers will build upon existing evidence-based models to pilot innovative approaches to increase access to dental services for children with NDDs, advance the skills and knowledge of your workforce to support access to services, and improve patient outcomes. Applicants for this funding must propose project work plans that include: Specific evidence-based models and innovative approaches that will increase access to dental services and improve patient outcomes for children with NDDs.Plans to advance the skills and knowledge of the health center workforce to support access to dental services for children with NDDs.
Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (NRSA)
The National Research Service Award (NRSA) program supports the training of postdoctoral researchers in biomedical, behavioral, and health services research. Funded by the National Institutes of Health (NIH) and administered in part by the Health Resources and Services Administration (HRSA), the program aims to develop a skilled research workforce to advance scientific knowledge in primary care. Under HRSA, the NRSA program provides support to train postdoctoral health care professionals who are planning to pursue careers in biomedical and behavioral health research related to primary care. As the nation’s population grows and ages, the need for well-trained primary care researchers to study the complex array of issues facing the primary care workforce gains greater importance. The NRSA Institutional Research Training Grants administered by HRSA are awarded to eligible institutions to develop or enhance postdoctoral research training opportunities for individuals who are planning to pursue careers in primary care research.
Pediatric Mental Health Care Access Program (PMHCA)
The Pediatric Mental Health Care Access (PMHCA) program helps improve mental and behavioral health for children and youth by giving pediatric primary care providers quick access to tele-consultation, training, and care coordination support.
Garrett Lee Smith Campus Suicide Prevention
The purpose of this program is to support a comprehensive public health and evidence-based approach that: (1) enhances behavioral health services for all college students, including those at risk for suicide, depression, serious mental illness (SMI)/serious emotional disturbances (SED), and/or substance use disorders that can lead to school failure; (2) prevents and reduces suicide and mental and substance use disorders; (3) promotes help-seeking behavior and reduces stigma; and (4) improves the identification and treatment of at-risk college students so they can successfully complete their studies. Note: Cost-sharing is waived for minority-serving institutions and community colleges.
Project AWARE (Advancing Wellness and Resiliency in Education)
The purpose of Project AWARE is to develop a sustainable infrastructure for school-based mental health programs and services. Award recipients should build collaborative partnerships with the State Education Agency, Local Education Agency, Tribal Education Agency, the State Mental Health Agency, community-based providers of behavioral health care services, school personnel, community organizations, families, and school-aged youth.
Certified Community Behavioral Health Clinic (CCBHC) Improvement and Advancement Grant
The purpose of this program is to sustain and enhance services at existing Certified Community Behavioral Health Clinics serving individuals across the lifespan with or at risk for mental health and/or substance use disorders.
Certified Community Behavioral Health Clinics (CCBHCs) Planning, Development, and Implementation Grant
The purpose of this program is to develop and establish new Community Behavioral Health Clinics to address gaps in behavioral health services and improve the wellbeing of persons with mental health and substance use disorders.
Cooperative Agreements for Certified Community Behavioral Health Clinic (CCBHC) Planning Grants
The purpose of the CCBHC State Planning Grant program is to support states in: Developing and implementing certification systems for CCBHCs.Establishing Prospective Payment Systems (PPS) for Medicaid reimbursable behavioral health services.Preparing an application to participate in a four-year Section 223 CCBHC Demonstration program. The purpose of this program is to support states in developing and implementing certification systems for CCBHCs, establish Prospective Payment Systems (PPS) for Medicaid reimbursable services, and prepare an application to participate in a four-year CCBHC Demonstration program.
Innovation in Behavioral Health (IBH)
The Innovation in Behavioral Health (IBH) Model (the “Model”) for Cohort II Recipients is a seven-year, voluntary service delivery and payment model promoting integrated care in behavioral health (BH) settings. The IBH Model will test the impact of a value-based payment (VBP) model aligned across Medicaid and Medicare that supports an integrated care delivery framework in specialty BH organizations and settings for adult Medicaid, Medicare, and dually eligible beneficiaries with moderate to severe mental health conditions and/or substance use disorders (SUDs). The Centers for Medicare & Medicaid Services (CMS), through its Center for Medicare & Medicaid Innovation (Innovation Center), will select up to five state Medicaid agencies (SMAs) to participate in the Model. The Model will have a seven-year performance period, which will be comprised of a two-year Pre-Implementation Period (beginning January 2027 and ending December 2028) along with a five-year Implementation Period (beginning January 2029 and ending December 2033). Up to $7.5 million dollars in cooperative agreement award funding will be available to each selected Recipient over the course of the seven years.
Expanding Global Health Security through local partnerships in Senegal
This NOFO aims to enhance Senegal's public health infrastructure to prevent, detect, and respond to infectious disease threats through implementing partners. The initiative focuses on strengthening public health surveillance systems, including community-based surveillance, improving laboratory networks, and enhancing workforce training. The goal is to build sustainable, resilient health security infrastructure, aligning with Global Health Security Agenda (GHSA) objectives. Partners will collaborate to promote cross-sectoral coordination and foster innovative approaches.
Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions
The National Institute of Dental and Craniofacial Research (NIDCR) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that—individually, sequentially, or in combination—contribute to human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses, e.g., causal explanation and causal inference—rather than statistical association, also are encouraged. Project results should be poised for clinical trials translation to prevent, treat, and manage dental, oral, and craniofacial (DOC) and related conditions. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area of behavioral, biological, biopsychosocial, public, and social sciences are encouraged to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in dental, oral, craniofacial, and systemic health over the life course, including care and services, will be encouraged, and these investigators also should begin to consider applying. NIDCR is authorized to forecast this opportunity under the Public Health Service Act (42 U.S.C §§ 241 and 284) and federal regulations (42 CFR Part 52 and 2 CFR Part 200).
Notice of Intent to Publish a Funding Opportunity Announcement for Impact of Technology and Digital Media Exposure Usage on Child and Adolescent Development
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the impact of technology and digital media on children and adolescents. Technology and digital media (TDM) encompasses social media, applications, websites, television, motion pictures, artificial intelligence, mobile devices, computers, video games, virtual and augmented reality, and other content, networks, or platforms disseminated through the internet, broadcasted, or other media technologies, as applicable. Collectively, they have become an integral part of our children’s and families’ daily lives. Most children and adolescents now engage with TDM starting from an early age, often with high levels of exposure across multiple devices and contexts and involving a wide range of content. There is therefore an urgent need to understand how TDM use and exposure impacts children’s health and development, as well as how it alters the very nature of interactions between children and their family members, peers, and society at large. As TDM has evolved with breathtaking speed, our understanding of its impacts – whether positive, neutral, or negative – on children’s health and development has not kept pace. This initiative intends to address this expanding gap by inviting research proposals on the impact of TDM on children and adolescents, including potential broader effects on their families and communities. Please note that applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize a phased R61/R33 mechanism. Investigators with interests at the intersection of TDM and child/adolescent development are encouraged to apply. In addition, collaborative teams that combine expertise across domains such as behavioral sciences, cognition and learning, computational and statistical modeling, computer science, geographic information science, library and information sciences, neurodevelopment, pediatrics, social and affective development and social sciences will be encouraged, and these investigators should also consider applying for this opportunity.
Molecular, Neural, and Cognitive Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders
The National Institute on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to encourage basic research on Non-Invasive Brain Stimulation (NIBS) using animal and human models. NIBS techniques transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial focused ultrasound (tFUS) have emerged as promising approaches to treat addiction and substance use disorders (SUDs); however, their mechanisms of action are unclear. This initiative is to support research to (1) elucidate molecular, cellular, and circuit level changes induced by NIBS protocols (2) identify molecular mechanisms and pathways by which NIBS techniques and protocols produce their therapeutic effects in SUDs,(3) identify novel clinical targets for NIBS, and (4) investigate SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that may precede clinical outcomes. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into neuromodulation by non-invasive brain stimulation are encouraged to apply. In addition, collaborative investigations combining expertise in non-invasive brain stimulation and substance use and addiction are encouraged.
NIH Science Education Partnership Award (SEPA)
The NIH Science Education Partnership Award (SEPA) program supports innovative educational activities that encourage pre-college students (pre-kindergarten to grade 12), to pursue further studies in science, technology, engineering, and mathematics (STEM), particularly in the biomedical and behavioral sciences. The program will support classroom-based projects for pre-kindergarten to grade 12 (pre-college) students and teachers and informal science education (ISE) projects conducted in outside-the-classroom venues such as after-school science programs and libraries. Projects that support quantitative and computational skills development are strongly encouraged.
Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)
The National Institue on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on pioneering research in HIV and Substance use/substance use disorder (SUD) research. The Avant-Garde Award Program is designed to support exceptionally creative scientists who propose cutting edge high risk and high reward and possibly transformative approaches to major challenges in biomedical and behavioral research on HIV in the context of substance use and/or SUDs. This Program includes supporting early stage investigators (ESI). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the DP1 activity code. Investigators with expertise and insights into this area of substance use and HIV are encouraged to begin to consider applying for this new NOFO.
HIV Prevention and Alcohol (R01 Clinical Trials Optional)
The NOFO seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. This includes integration of effective prevention and treatment interventions with an understanding of the overarching framework for reducing the incidence of new infections by facilitating cross-cutting informative research. This research activity includes the development and testing of new interventions and expansion of existing effective interventions as well as the implementation of these integrative preventive activities in a variety of settings and populations. Six areas of research are of primary interest related to alcohol use and related mental health and substance use comorbidities. These include but are not limited to 1) PrEP Utilization, 2) Treatment as Prevention (TasP), 3) Integration of Preventive Intervention Strategies, 4) Prevention-related Cross-cutting Research, 5) Syndemic Approaches and, 6) Implementation and Operations Research.
Health Equity Data Access Program (HEDAP)
The Health Equity Data Access program (HEDAP) provides funding for six (6) “seats” in the CMS Virtual Research Data Center (VRDC). The VRDC assists researchers in gaining access to CMS restricted data for minority health research. Seats, in this context are defined as an individual user with VRDC access. These researchers will conduct health services research on health care topics such as physical health, oral health, behavioral health, population health, and social determinants of health focusing on, but not limited to, racial and ethnic minority groups; people with disabilities; members of the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community; individuals with limited English proficiency; individuals residing in rural areas; and individuals (including children, youth, and families) adversely affected by persistent poverty or inequality. The HEDAP supports specific applied research projects that relate to creative and innovative methods utilizing CMS data to identify, document, assess, and evaluate health disparities among Medicare and Medicaid and CHIP enrollees. The project should enhance the capacity of the researcher to understand and utilize CMS data in future research projects. Additionally, HEDAP encourages cutting-edge proposals that explore intersectionality. “Intersectionality” means that people belong to more than one group and, therefore, may have overlapping health and social inequities, as well as overlapping strengths and assets. Results of the HEDAP will provide CMS and its partners, (e.g. Quality Improvement Organizations, Hospital Engagement Networks, and other stakeholders) with actionable information on the subgroups of enrollees. This will aid the efforts of CMS and its agents to identify and eradicate health disparities in underserved populations. VRDC seat access will be funded for a period of 36 months each, based on the availability of funds.
Identification of Drug-related and Formulation-Related Factors that Result in Alcohol Dose Dumping of Modified Release Oral Drug Products (U01) Clinical Trial Not Allowed
Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.
Improving Predictability of Food-Drug and Drug-Drug Interaction Risks by Utilizing In Vitro Simulated Gastrointestinal Dissolution Model for High-Risk Oral Drug Products (U01) Clinical Trial Optional
The purpose of this funding opportunity is to examine the utility of an in vitro simulated gastrointestinal (GI) dissolution model for the assessment of in vitro performance of amorphous solid dispersion (ASD) drug products under different clinically relevant conditions. The goal is to develop and validate the in vitro mechanistic methodology to provide an improved understanding of impact of food and acid reducing agents on the absorption for test and reference listed drug (RLD) drug products, taking into consideration their potentially different formulations and manufacturing. The bio predictive in vitro mechanistic methodology is intended to correlate the in vitro observations to in vivo outcomes, help define types of in vivo bioequivalence (BE) studies needed for ASD drug products, and inform regulatory decision-making related to mitigating the risk of potential failure modes for therapeutic equivalence for high-risk generic oral drug products.
Integrating Machine Learning with Computational Fluid Dynamics Models of Orally Inhaled Drug Products (U01) Clinical Trials Not Allowed
Computational fluid dynamics (CFD) has played a crucial role in providing an alternative bioequivalence (BE) approach for generic orally inhaled drug products (OIDPs), in addition to comparative clinical endpoint or pharmacodynamic BE studies, as a relatively cost- and time-efficient complement to benchtop and clinical experiments that has been widely used in developing and assessing generic inhaler devices. However, despite the advances in the power of modern computers, there are still some bottlenecks in using CFD due to computational time, limited grid resolution, pre- and post-processing of large simulation data sets, model parameter estimations, and uncertainty quantifications. Machine learning (ML) has been gaining more attention as a potential tool to alleviate such limitations that arise in CFD. The purpose of this grant is to develop a methodology to integrate ML with CFD models of OIDPs to promote alternative BE studies to enhance and accelerate the development and approval of generic OIDPs.
State Veterans Home Construction Grant Program
Improving Oversight of Federal GrantmakingVA is required to ensure compliance with all applicable statutes, regulations, and Executive Orders when evaluating and awarding grants. In accordance with Executive Order 14332, Improving Oversight of Federal Grantmaking, aside from the evaluation criteria published in this announcement, VA has discretion to remove from consideration any applicant VA deems does not clearly advance the President's or VA's priorities. VA will not fund activities that use racial preference for eligibility criteria or promote gender ideology. VA will not fund activities that promote or facilitate violations of immigration laws or are sources of waste, fraud, or abuse. VA will not tolerate activity or conduct by grant recipients that constitute acts of moral turpitude, are scandalous, or bring the recipient, the project funded by this grant, or VA into public disrepute, contempt, or ridicule. These grants support the President's priority to increase the excellence of and options for care, benefits, and services for veterans, as demonstrated in Executive Order 14332. Program is subject to Public Law 117-58 Build America, Buy America Act. Recipients of an award of Federal financial assistance from a program for infrastructure are hereby notified that none of the funds provided under this award may be used for a project for infrastructure unless:(1) all iron and steel used in the project are produced in the United States--this means all manufacturing processes, from the initial melting stage through the application of coatings, occurred in the United States; (2) all manufactured products used in the project are produced in the United States—this means the manufactured product was manufactured in the United States; and the cost of the components of the manufactured product that are mined, produced, or manufactured in the United States is greater than 55 percent of the total cost of all components of the manufactured product, unless another standard for determining the minimum amount of domestic content of the manufactured product has been established under applicable law or regulation; and (3) all construction materials44 are manufactured in the United States—this means that all manufacturing processes for the construction material occurred in the United States. The Buy America preference only applies to articles, materials, and supplies that are consumed in, incorporated into, or affixed to an infrastructure project. As such, it does not apply to tools, equipment, and supplies, such as temporary scaffolding, brought to the construction site and removed at or before the completion of the infrastructure project. Nor does a Buy America preference apply to equipment and furnishings, such as movable chairs, desks, and portable computer equipment, that are used at or within the finished infrastructure project, but are not an integral part of the structure or permanently affixed to the infrastructure project. Grants are available to State and Tribal Governments for construction or renovations of State/Tribal owned and operated Veterans Extended Care Facilities. The Department of Veterans Affairs participation may not exceed 65% of the total project costs. Review governing regulation before submitting an application (38 CFR Part 59). If the state is submitting a new grant application, it must submit a complete initial application (Section A of the project checklist) on Grants.gov by April 15th in order to be eligible for listing on the Priority List for the next fiscal year. Once the complete initial application is retrieved from Grants.gov by Program Staff, the grant applicant will receive 1) an automated notification from Grants.gov confirming receipt by the Program and 2) an email from Program Staff indicating the application's FAI number and corresponding project page in MAX.gov for submission of subsequent items. Note that Grants.gov is used only once to submit a new grant application. Applicants must submit complete initial applications on Grants.gov in order to be considered. Please contact Program Staff prior to submission if you need assistance understanding the requirements pertaining to an initial grant application, or if you need general assistance. Renovation or Life Safety initial grant applications require items A.1.-A.7. in Section A of the project checklist. Grant applicants, do not submit items A.8.-.A.13 for Renovation of Life Safety grants. Adult Day Health Care, New Home Construction or Bed Replacement initial grant applications require all items in Section A (A.1.-A.13) of the project checklist. Required for ALL applications A.1.A Project Scope A.1.B Form SF424 A.1.C Form SF424D A.1.D Form SF424C A.1.E Budget Justification Worksheet (must align with SF424C budget form) A.2. Governor's designation of authorized state official and contact person A.3. Needs assessment (as outlined in VA Form 10-0388-1) A.4. State Clearinghouse Comments (E.O. 12372) single point of contact and compliance statement A.5. Schematics A.6. Signed Initial Application Certification VA Form 10-0388-1 A.7. Safety citation/letter (Only Life Safety projects need to submit this). Required for Adult Day Health Care, Bed Replacement or New Construction - Items A1-A6 and the below items A.8. Space program analysis (NHC use Form 10-0388-3, ADHC use Form 10-0388-4) A.9. Five-year capital plan for state's entire state home program A.10. Financial plan for state facility's first three years of operation A.11. Documentation that there is a reasonable basis to conclude that the facility when complete will be fully occupied A.12. Authorized state official's certification of the total number of state-operated nursing home and domiciliary beds and occupancy rate A.13. Authorized state official's certification that the number of state home beds does not exceed the requirement in 38 CFR 59.40 or justification for number of state home beds exceeding 38 CFR 59.40 based on travel distance