Behavioral Health
Funding for mental health services and behavioral health integration.
Screening, Brief Intervention and Referral to Treatment
The purpose of this program is to implement the Screening, Brief Intervention, and Referral to Treatment public health model for children, adolescents, and/or adults in primary care and community health settings (e.g., health centers, hospital systems, HMOs, PPOs, health plans, FQHCs, behavioral health centers, pediatric health care providers offices, children’s hospitals) and schools, with a focus on screening for underage drinking, opioid use, and other substance use.
State Pilot Program for Treatment for Pregnant and Postpartum Women
The purpose of this program is to strengthen and expand integrated, evidence-based substance use disorder (SUD) and maternal mental health services for pregnant and postpartum women and their families. The program seeks to improve maternal and infant health outcomes by addressing SUD and co-occurring substance use and mental health conditions through comprehensive screening, treatment, recovery supports, and workforce development. Priority populations include pregnant and postpartum women with primary diagnoses of SUDs, including opioid use disorder, and co-occurring mental health conditions, their infants and families, and communities disproportionately impacted by maternal morbidity and mortality.
Center of Excellence for Protected Health Information Related to Behavioral Health
The purpose of this program is to implement a National Center of Excellence to develop and disseminate training, technical assistance, and educational resources for healthcare practitioners, families, individuals, states, and communities on federal privacy statutes and regulations as they relate to behavioral health data.
Behavioral Health Partnerships for Early Diversion of Adults and Youth
The purpose of this program is to develop and implement infrastructure that supports programs that divert adults and/or youth with a mental illness or a co-occurring substance use disorder from the criminal and/or juvenile justice systems prior to arrest and booking.
Promoting Integration of Primary and Behavioral Health Care: States
The purpose of this program is to: promote full integration and collaboration in clinical practices between physical and behavioral health care; support the improvement of integrated care models for physical and behavioral health care to improve overall wellness and physical health status; and promote the implementation and improvement of bidirectional integrated care services, including evidence-based or evidence-informed screening, assessment, diagnosis, prevention, treatment, and recovery services for mental and substance use disorders, and co-occurring physical health conditions and chronic diseases.
Behavioral Health Mobile Crisis Team Partnerships
The purpose of this program is to establish new, or enhance existing, mobile crisis teams that serve children, youth, and adults experiencing mental health or substance use crises. Its focus is the expansion of behavioral health crisis response capacity and the development of structured partnerships that reduce reliance on law enforcement and emergency departments for behavioral health crises.
Grants to Expand Substance Use Disorder Treatment Capacity in Adult and Family Treatment Drug Courts
The purpose of this program is to expand substance use disorder (SUD) treatment and recovery support services in existing drug courts. Grant recipients will be required to implement a coordinated, multisystem approach that combines the legal authority of treatment drug courts with evidence-based SUD treatment services. Key stakeholders include the judiciary, prosecution, defense attorneys, probation services, law enforcement, mental health professionals, social service agencies, and treatment providers. The objective is to disrupt the recurring pattern of criminal behavior, substance use, and incarceration or other legal consequences.
Infant and Early Childhood Mental Health
The purpose of this program is to develop or enhance infant and early childhood mental health promotion and intervention programs for young children.
Statewide Consumer Network
The purpose of this program is to strengthen the capacity and sustainability of statewide mental health peer-run organizations.
Statewide Family Network
The purpose of this program is to enhance the capacity of statewide, mental health family-controlled organizations to support, train, and mentor family members/primary caregivers.
Trauma-Informed Services in Schools
The purpose of this program is to increase student access to evidence-based support services and mental health care by developing innovative initiatives, activities, and programs to link local school systems with local trauma support and mental health services. Note: At least one award will be made to tribes or tribal organizations pending adequate application volume.
Mental Health Awareness Training Grants
The purpose of this program is to facilitate the implementation of mental health awareness and literacy training.
Screening & Treatment for Maternal Mental Health and Substance Use Disorders (MMHSUD)
The MMHSUD Program helps improve maternal mental health and substance use disorder outcomes for pregnant and postpartum women by providing obstetric, primary care, and other maternal health providers with timely access to teleconsultation, training, and care coordination support including resource and referrals.
Public Health Strategies to Address Alzheimer's Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator
Alzheimer's disease, the most common form of dementia, is a progressive condition. It begins with mild memory loss and may lead to the inability to communicate or respond to one's environment. Its prevalence is rising with the aging U.S. population. In 2021, it was the 5th leading cause of death for those 65 and older, with death rates continuing to climb. The CDC Alzheimer's Disease Program, through the National Healthy Brain Initiative (HBI) and funded partners, promotes brain health, addresses cognitive impairment, and supports caregivers using evidence-based approaches. This funding opportunity aligns with the HBI Road Map Series (including the State and Local Road Map 2023–2027 and the Road Map for Indian Country) and fulfills the aims of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406). Funding Structure: Component 1: National Healthy Brain Initiative: Funds up to two (2) organizations to develop and implement public health strategies guided by the HBI Road Map Series. Funded organizations will: Develop evidence-informed training for health care and public health professionals on ADRD and caregiving. Expand the availability and use of public health surveillance data, including adaptation & revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline and caregiver optional modules. Facilitate the coordination of recipients and national partners to address ADRD. Funding range: $2,500,000 to $3,000,000 per 12-month budget period. Component 2: BOLD Public Health Centers of Excellence: Funds three (3) Centers, each specializing in one of three topic-specific areas: dementia risk reduction, early detection and management of dementia, or dementia caregiving. Centers will: Support the needs of the BOLD public health program and other public health agencies. Identify, disseminate, and promote best practices. Translate promising research into practical tools and resources. Increase professional education and develop materials to address specific individual needs to improve health outcomes. Funding range: $750,000 to $1,000,000 per 12-month budget period. Component 3: ADRD Public Health Adoption Accelerator. Funds up to two (2) organizations to serve as public health strategy adaptation accelerator programs. This means using dissemination and implementation of science to spread and put into practice effective public health strategies, tools, and resources to tackle ADRD. Organizations will: Collaborate with CDC and other organizations to create a prioritized list of ADRD approaches & strategies. Use proven strategies to engage partners, health care organizations, and policymakers to enhance uptake and implementation, accelerating the impact of ADRD efforts. Provide technical assistance to Component 1 & 2 recipients. Funding range: $750,000 - $1,200,000 per 12-month budget period. Applicants may apply for multiple components, but must submit a separate application per component.
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close gaps in health outcomes within the US population and increase health for all.Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, participant recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination. The application should also describe its approaches to increase community engagement from conceptual design of the intervention through implementation and sustainability, close gaps in health outcomes within the US population, and increase health for all.
BJA FY25 Veterans Treatment Court Program
This NOFO will support the implementation and enhancement of veterans treatment court (VTC) operations. VTCs connect justice-involved veterans to treatment for substance use disorders (SUD), mental health disorders (MHD), co-occurring mental health and substance use disorders (MHSUD), post-traumatic stress disorder (PTSD), and traumatic brain injury (TBI). Funding supports service coordination, and recovery support services. VTCs integrate mandatory drug testing, incentives and sanctions, and transitional services in judicially supervised criminal court settings that have jurisdiction over veterans with behavioral health treatment needs. These courts aim to reduce recidivism and overdose fatalities, while increasing access to treatment and recovery support that leads to long-term recovery.
OJJDP FY25 Juvenile Drug Treatment Court Program
This NOFO will support states, state and local courts, units of local government, and federally recognized Tribal governments to implement new and enhance existing juvenile drug treatment courts (JDTCs) to improve outcomes for youth with substance use disorders or co-occurring substance use and mental health disorders.
Regional Pediatric Prevention Network
The purpose of this program is to support a Regional Pediatric Prevention Network (RPPN). The RPPN strengthens local and regional capacity to care for children during disasters and emergencies through community partnerships, coordinated pediatric preparedness, and dissemination of research-informed pediatric disaster care. The RPPN will include at least 10 children’s hospitals, or their university pediatric partners, funded through two primary awards. It will also include community partners working with these hospitals. Each of the 10 Children’s Hospital centers will advance pediatric emergency and disaster preparedness at the local, regional, and national levels, including for children with special health care needs and behavioral health concerns, children living in poverty, and children in rural, remote, and tribal areas.
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit research applications for practice-based research centers to support interdisciplinary teams of mental health researchers to engage in high-impact studies that will significantly advance clinical practice and generate knowledge to fuel the transformation of mental health care in the United States. Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers support research projects aimed at the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders; (2) developing and testing empirically informed patient-, provider- and system-level interventions to improve mental health care access, engagement, continuity, efficiency, and quality; and (3) continuously improving the quality, impact, and durability of optimized interventions and health for individuals with or at risk for mental health problems, including those with serious mental illness. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive research projects. This NOFO will utilize the P50 activity code. Applications must propose research that maximizes synergies across various components of the mental health research ecosystem, including new discoveries in clinical research, transformative health care technologies, advances in information science, and new federal and state mechanisms for organizing mental health care. Applicants with interdisciplinary expertise, such as behavioral science, health information and data science, health systems engineering, decision science, implementation science, and related fields, whose practice-based research needs cannot be met through standard research project grant mechanisms, should consider applying to this NOFO. Applications are also expected to include research activities that facilitate the widespread sharing of data, methods, and resources to accelerate clinical research and to provide opportunities for graduate students, postdoctoral researchers, and early-career investigators to participate in interdisciplinary research-to-practice translational mental health research.
Transforming Pediatrics for Early Childhood (TPEC) Program
The Transforming Pediatrics for Early Childhood Program (TPEC) will advance the U.S. Department of Health and Human Services’ Make America Healthy Again (MAHA) priorities by preventing chronic disease early in life and promoting healthy development in early childhood. TPEC recipients - organizations with statewide or tribal reach - will place early childhood development (ECD) experts in local pediatric practices to deliver team-based care to young children and their families. Recipients will improve the quality and cost effectiveness of pediatric primary care by delivering a comprehensive team-based approach that focuses on factors critical to child development. Through this approach, pediatric primary care staff will: Screen families for their needs related to mental health, housing, nutrition, and child development; Build safe, stable, and nurturing relationships between caregivers and their children; Educate caregivers on developmental milestones and how to watch for them; and Make sure that families get referrals and access to additional or specialized support. TPEC recipients will: Place early childhood development (ECD) experts in pediatric practices that primarily serve families covered by Medicaid/Children’s Health Insurance Program (CHIP) and deliver high-quality ECD services using a team-based approach.Build the skills of pediatric primary care staff statewide to deliver high-quality ECD services using a team-based approach. Improve statewide administrative policies and financing strategies to expand and sustain team-based pediatric primary care, improving the standard of care for all young children. TPEC will result in measurable improvements in service delivery rates and early childhood development outcomes.
Make America Healthy Again – Enhancing Lifestyle and Evaluating Value-based Approaches Through Evidence
The Centers for Medicare & Medicaid Services (CMS), through its Centers for Medicare and Medicaid Innovation (CMMI or Innovation Center), is soliciting applications for the Make America Healthy Again: Enhancing Lifestyle & Evaluating Value-based Approaches Through Evidence (MAHA ELEVATE) Model. This voluntary, three-year service delivery model is designed to test evidence-based, whole-person functional or lifestyle medicine (“whole-person FLM”) approaches to care. Rather than treating diseases separately after they develop, MAHA ELEVATE takes a proactive, comprehensive approach that combines psychological, nutritional, and physical interventions with personalized, lifestyle-based strategies for prevention and early treatment. Throughout this NOFO, we use the term “whole-person FLM” to represent a range of services or approaches often incorporated in lifestyle and functional medicine that are not currently covered under Medicare. It is important to clarify that CMS is not establishing a new industry standard through the use of this terminology. The term “whole-person FLM” as used in this NOFO does not represent an attempt by CMS to create, define, or establish any new industry-wide standard, practice guideline(s), or healthcare delivery model beyond the scope of this specific Innovation Center model and funding opportunity. Similarly, through this funding opportunity, CMS is not creating a new category of covered services for Medicare purposes. This term serves solely as a descriptive reference within this document to facilitate clear communication about the non-covered services being tested in this model and should not be interpreted as having any regulatory, coverage, or policy implications beyond the context of this specific Innovation Center model. CMS will select a total of up to 30 Recipients to participate in MAHA ELEVATE. The model will be split into two cohorts, one year apart (years 2026 and 2027). CMS will select recipients based on five key criteria: • Whole-person FLM intervention design, including cost savings. • Beneficiary recruitment and study design. • Organizational and administrative capacity. • Data management capabilities. • Budget. Highly competitive applicants must demonstrate several important strengths: • Strong, evidence-based support for your proposed intervention(s) and proof of your own successful history of implementation of the intervention and cost savings. • Ability to recruit large numbers of participants with a clear randomization plan and advanced data management capabilities. Given the model’s minimum beneficiary targets and extensive data management requirements, applicants who do not directly provide clinical care are strongly encouraged to form partnerships with care entities or organizations that deliver clinical care. This collaboration helps ensure you can meet the full operational requirements of the program.
Staff Sergeant Fox Suicide Prevention Grant Program Funding Opportunity
Description: The Department of Veterans Affairs (VA) is announcing the availability of funds for new and renewing suicide prevention grants under the Staff Sergeant Fox Suicide Prevention Grant Program (SSG Fox SPGP) for services in Federal Fiscal Year (FY) 2027. The SSG Fox SPGP directs efforts to reduce Veteran suicide by awarding grants to community-based organizations to directly provide or coordinate the provision of primarily non-clinical suicide prevention services to eligible individuals and their families. Eligible individuals include certain Veterans and Active-Duty Service Members as defined by statute and regulations. Veteran suicide risk is reduced by services that improve mental health status, well-being, financial stability, and social support. Services provided by grantees may include case management, peer support, linkage to VA care and benefits, emergency clinical services, faith-based or innovative approaches. Most Veterans who die by suicide were not engaged with VA in the years prior to their deaths. This program addresses a critical gap by engaging and serving Veterans at risk for suicide who were previously out of VA’s reach and their family members. These grants support the President’s commitment to increase the excellence of and options for care, benefits, and services for veterans, as well as improve the delivery and quality of the Department's healthcare services in a more efficient and effective manner to support veterans, as demonstrated in Executive Order 14296 – Keeping Promises to Veterans and Establishing a National Center for Warrior Independence. This NOFO contains information concerning the SSG Fox SPGP, the grant application process, and the amount of funding available. For detailed program information and requirements, see 38 C.F.R. Part 78.
Disaster Distress Helpline (Short Title: DDH)
The purpose of the Disaster Distress Helpline (DDH) is to provide immediate, confidential, and accessible emotional support services to individuals and communities across the United States who are experiencing psychological distress related to natural or human-caused disasters. The DDH delivers 24/7 crisis counseling via phone and text, in multiple languages, to support disaster survivors, their families, responders, and others affected by disaster events.
Children's Mental Health Initiative
The purpose of the Children’s Mental Health Initiative program is to provide comprehensive community mental health services to children, youth, and young adults, birth through age 21 with a serious emotional disturbance, which may include efforts to identify and serve children at risk, and their families.
Community Reentry Settings Initiative
The release decision-making process is crucial to the criminal justice system and should be intentional and deliberate. Reentry decisions should consider factors such as the inmate’s risk, needs and responsivity (RNR) principles and community safety concerns. There has been some attention surrounding the utilization of halfway houses but, additional assessment and review is needed to understand the current state of halfway house utilization and make transformational changes that supports successful reentry outcomes in halfway houses. The questions to explore are simple and complex. For example, what and how is criteria (risk assessments, protective factors, etc.) used in the decision-making process from prison to halfway house; how are case managers planning for halfway house release with their residents; what does the “hand-off” from prisons officials to halfway house organizations entail; how are the community, business, education and other public or non-profit entities involved in this release process to halfway house and; what is the continuum of support/care provided during their reentry/transition period at half-way houses (e.g., employment, life skills, mental health, substance use). These are some of the broad questions this work seeks to answer. One notable dynamic to explore in the decision-making processes involves the tension between discretionary authority and standardized procedures. Multiple sources highlight that release decisions involve "discretionary judgment", and key actors like wardens, community corrections managers, and case managers are the final decision makers. How each of these actors makes decisions varies, leaving the possibility of subjective judgment in the process. Simultaneously, there are explicit legal mandates, state statutes, and zoning requirements that outline specific criteria, timelines, and procedures for release to halfway houses. While policies and assessment tools aim for consistency, fairness, and evidence-based decision making, the space where discretion exists can lead to variations in which individuals are being considered for release. This human factor introduces the potential for inconsistencies in eligibility determinations, or deviations from the policy and program criteria/design or inconsistent application of policy and procedures. This points to the dilemma between discretionary release practices versus standardized releasing decision-making. Therefore, a process evaluation created should be conducted to understand currently how discretion is applied within defined policy parameters. Dynamics to understand include: are policies consistently applied across different unit teams, case managers, or community corrections boards; are there informal norms or unwritten rules that influence decisions more than formal policy; what are the perceived trade-offs between strict adherence to policy and the flexibility needed for individualized case management? The primary objective is to systematically examine the current decision-making point governing the process of prison residents release to halfway houses. This process evaluation should aim to illuminate the operational realities and challenges in order for NIC to discern how those underlying factors can be changed and improved upon. By focusing on the “why” and “how” of this decision point, we will better understand halfway house placement implementation. Please note, this is NOT a funding opportunity to plan, establish, revise, fund, staff or build a halfway house in any community.
Delta Rural Integrated Health Network Program
The Delta Rural Integrated Health Network Program seeks to improve healthcare delivery in the region by supporting the development of integrated health networks among rural hospitals, primary care clinics, behavioral health providers and other essential services.
BJA FY25 Public Safety and Mental Health Initiative
This NOFO supports comprehensive service networks addressing untreated mental illness and substance use at the intersection of mental health, substance use, and justice systems. This program responds to the growing burden of endemic vagrancy, disorderly behavior and public safety threats faced by law enforcement agencies. These agencies are often positioned as first responders to situations better addressed by health and social service systems. Law enforcement and justice agencies nationwide need actionable alternatives that prioritize both public order and appropriate treatment settings for those experiencing mental illness or substance use disorders. Specifically, this initiative provides funding to support activities through four core areas: (1) crisis stabilization centers; (2) treatment services; (3) housing access; and (4) electronic health record (EHR) systems and technology modernization.
2026 Wood Innovations Grant Funding Opportunity
The USDA Forest Service requests proposals to substantially expand and accelerate wood energy and wood products markets throughout the United States to support forest management needs on National Forest System and other forest lands. The grants and agreements awarded under this announcement will support the Agriculture Improvement Act of 2018 Pub. L. 115-334 Sec. 8643, Rural Revitalization Technologies 7 U.S.C. Sec. 6601, and Infrastructure Investment and Jobs Act Pub. L. 117-58 Div. J Title VI to meet the nationwide challenge of disposing of hazardous fuels and other wood residues from the National Forest System and other U.S. forest lands in a manner that supports wood products and wood energy markets. This Request for Proposals focuses on the following priorities to: 1.) Reduce wildfire risk and improve forest health on National Forest System and other forestlands; 2.) Reduce costs of forest management on all land types; 3.) Promote economic and environmental health of communities. The intent of the Wood Innovations Funding Opportunity is to stimulate, expand, and support wood products markets and wood energy markets. Projects can include, but are not limited to: Completing requirements, such as engineering designs, cost analyses, and permitting necessary, in the later stages of commercial construction projects that use wood as a primary building material and in the later stages of wood energy project development to secure financing. Early phase project development proposals will not be competitive. Developing manufacturing capacity, other necessary wood products infrastructure, and markets for wood products that support forest ecosystem restoration. Showcasing quantifiable environmental and economic benefits of using wood as a sustainable building material in an actual commercial building and the projected benefits achieved if replicated across the United States based on commercial construction market trends. Establishing statewide wood utilization teams and statewide wood energy teams. Only proposals from States without an existing (or former) team will be considered. Developing a cluster of wood energy projects in a geographic area or specific sector (e.g., prisons, hospitals, universities, manufacturing sector, or industrial sector). Overcoming market barriers and stimulating expansion of wood energy in the commercial sector. Additional details on the funding opportunity can be found at Wood Innovations Home page Instructions on how to apply for funding and the required Application Form can be downloaded at the following weblinks. **Note - Wood Innovations Application Form (FS-1500-50) has been corrected to address character/space limitations. Wood Innovations Funding Opportunity Application (FS-1500-0050) Instructions FY26 Wood Innovations Funding Opportunity Wood Innovations Application Webinar Wood Innovations Grant Factsheet Applications must be submitted in Grants.gov by 11:59 ET on April 22, 2026.
Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials
The National Institute on Drug Abuse seeks to support pilot and feasibility studies in preparation for efficacy, effectiveness and/or services research trials. Topics may include:1) developing interventions to prevent substance use, misuse or progression to disorder, 2) substance use prevention, treatment or recovery services research, including comorbid pain, medical and mental health disorders, 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations. Projects may address information gaps, strengthen stakeholder partnerships, or pilot test interventions. Activities might include intervention development/adaptation; assessing intervention or service model acceptability and feasibility; and development of measures, materials, or methods for the future trial. Preliminary data is not required. A well-defined theory of change or logic model is expected. Applicants must engage relevant end users in study design, execution, and interpretation (e.g., policymakers, state and local decision makers, practitioners, individuals with lived/living experience, families, youth, and community members). Applications are not being solicited at this time. This notice is to allow applicants time to develop collaborations and responsive projects. Grant authorities that allow this forecast are 42 U.S.C. §§ 241 and 284.
Providers Clinical Support System – Substance Use Disorder Treatment (PCSS-SUD Treatment)
The purpose of this program is to provide training and technical assistance (TTA), mentoring, and ongoing support for healthcare professionals in general health and behavioral health settings to increase their capacity to identify and treat substance use disorders (SUDs), especially opioid and alcohol use disorders.
Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY) Existing Geographic Service Areas
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services). The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV, to directly remove barriers to care for the person with HIV, or to promote family stability.
Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services. The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV , to directly remove barriers to care for the person with HIV, or to promote family stability. The purpose of this supplemental funding is to strengthen organizational capacity to respond to the changing health care landscape and increase access to high quality family-centered HIV primary health care services for low-income women, infants, children and youth (WICY) with HIV. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Rural Communities Opioid Response Program (RCORP)-Planning
Rural Communities Opioid Response Program (RCORP)-Planning supports organizations in rural communities to build the partnerships and foundational capacity needed to develop, implement and sustain a comprehensive system of substance use disorder (SUD) and related services. RCORP’s focus is on opioid misuse and its impact on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Individuals struggling with SUD, including opioid use disorder (OUD), need a continuum of mental, behavioral, and related social supports. RCORP-Planning helps address these needs in a comprehensive way. This program is intended for rural communities that may find the logistics or requirements of larger, more complex federal grant programs to be barriers to accessing start-up support. Funding will serve as a critical first step to creating SUD service systems that make care easy to access, strengthen the behavioral health workforce, and have strong community buy-in. It will help prepare communities to provide sustainable prevention, treatment, recovery, and other supportive services that: reduce substance use initiation and misuse,address the mental, behavioral, and psychosocial needs of people who use illicit substances or misuse alcohol, or are in recovery from substance use problems, andreduce disease and death related to substance use problems, including OUD, in high-risk rural communities.The intent of this program is to fund planning activities only. Funds may not be used for direct service delivery.
Rural Communities Opioid Response Program (RCORP)-Impact
The Rural Communities Opioid Response Program (RCORP)–Impact funds rural communities to drive measurable improvements in access to integrated, coordinated treatment and recovery services for substance use disorder (SUD), including opioid use disorder (OUD). Its long-term aim is to reduce morbidity and mortality associated with SUD and enable sustained recovery and well-being. The program supports: New or expanded evidence-based SUD prevention, treatment, and recovery services in rural areas;Coordination across health and supportive social services to enable sustained, long-term recovery;A larger, more responsive workforce to address SUD-related needs; andMulti-sector community networks to strengthen and sustain local service delivery.The focus of RCORP-Impact is on reducing the impact of opioid misuse on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Therefore, RCORP-Impact supports a comprehensive approach to address all SUD, including OUD, within a continuum of mental, behavioral, and related social supports.
Early Childhood Comprehensive Systems SEED Project: Scaling Effective Early Childhood Systems Development (ECCS SEED)
The purpose of the Early Childhood Comprehensive Systems SEED Project: Scaling Effective Early Childhood Systems Development (ECCS SEED) is to address the root causes of chronic disease in early childhood by improving families’ access to health care, screening kids early for physical and mental health needs, and connecting parents to services that enable them to provide for their children. The ECCS SEED Project will partner with states and communities to support evidence-based strategies that improve access to quality care for prenatal-to-age-5 (P-5) families and promote healthy child development and family well-being.
Rural Residency Planning and Development Program
The Rural Residency Planning and Development (RRPD) program improves and expands rural health care access. It does this by developing new, accredited, sustainable rural residency programs, including rural track programs (RTPs). Newly created rural physician residency programs increase training and ultimately practice in rural areas to address physician shortages. The RRPD program provides start-up funding to create new rural residency programs in qualifying medical specialties. Long-term sustainability funding must come from viable and stable sources, such as Medicare, Medicaid, and other public or private sources. Qualifying medical specialties are: Family medicine.Internal medicine.Preventive medicine.Psychiatry.General surgery.Obstetrics and gynecology.For this notice of funding opportunity (NOFO), rural residency programs: Are accredited physician residency programs.Train residents in clinical training sites that are physically located in a rural area as defined by HRSA’s Federal Office of Rural Health Policy (FORHP) for greater than 50 percent of their total time in residency.Focus on preparing physicians to practice in rural communities.
Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (NRSA)
The National Research Service Award (NRSA) program supports the training of postdoctoral researchers in biomedical, behavioral, and health services research. Funded by the National Institutes of Health (NIH) and administered in part by the Health Resources and Services Administration (HRSA), the program aims to develop a skilled research workforce to advance scientific knowledge in primary care. Under HRSA, the NRSA program provides support to train postdoctoral health care professionals who are planning to pursue careers in biomedical and behavioral health research related to primary care. As the nation’s population grows and ages, the need for well-trained primary care researchers to study the complex array of issues facing the primary care workforce gains greater importance. The NRSA Institutional Research Training Grants administered by HRSA are awarded to eligible institutions to develop or enhance postdoctoral research training opportunities for individuals who are planning to pursue careers in primary care research.
Pediatric Mental Health Care Access Program (PMHCA)
The Pediatric Mental Health Care Access (PMHCA) program helps improve mental and behavioral health for children and youth by giving pediatric primary care providers quick access to tele-consultation, training, and care coordination support.
Garrett Lee Smith Campus Suicide Prevention
The purpose of this program is to support a comprehensive public health and evidence-based approach that: (1) enhances behavioral health services for all college students, including those at risk for suicide, depression, serious mental illness (SMI)/serious emotional disturbances (SED), and/or substance use disorders that can lead to school failure; (2) prevents and reduces suicide and mental and substance use disorders; (3) promotes help-seeking behavior and reduces stigma; and (4) improves the identification and treatment of at-risk college students so they can successfully complete their studies. Note: Cost-sharing is waived for minority-serving institutions and community colleges.
Project AWARE (Advancing Wellness and Resiliency in Education)
The purpose of Project AWARE is to develop a sustainable infrastructure for school-based mental health programs and services. Award recipients should build collaborative partnerships with the State Education Agency, Local Education Agency, Tribal Education Agency, the State Mental Health Agency, community-based providers of behavioral health care services, school personnel, community organizations, families, and school-aged youth.
Certified Community Behavioral Health Clinic (CCBHC) Improvement and Advancement Grant
The purpose of this program is to sustain and enhance services at existing Certified Community Behavioral Health Clinics serving individuals across the lifespan with or at risk for mental health and/or substance use disorders.
Certified Community Behavioral Health Clinics (CCBHCs) Planning, Development, and Implementation Grant
The purpose of this program is to develop and establish new Community Behavioral Health Clinics to address gaps in behavioral health services and improve the wellbeing of persons with mental health and substance use disorders.
Cooperative Agreements for Certified Community Behavioral Health Clinic (CCBHC) Planning Grants
The purpose of the CCBHC State Planning Grant program is to support states in: Developing and implementing certification systems for CCBHCs.Establishing Prospective Payment Systems (PPS) for Medicaid reimbursable behavioral health services.Preparing an application to participate in a four-year Section 223 CCBHC Demonstration program. The purpose of this program is to support states in developing and implementing certification systems for CCBHCs, establish Prospective Payment Systems (PPS) for Medicaid reimbursable services, and prepare an application to participate in a four-year CCBHC Demonstration program.
Community Programs for Youth and Young Adults at Clinical High Risk for Psychosis
The purpose of this program is to provide trauma-informed, evidence-based interventions to youth and young adults (up to 25 years of age) who are at clinical high risk for psychosis.
Garrett Lee Smith State/Tribal Youth Suicide Prevention and Early Intervention Program
The purpose of this program is to support States and Tribes in implementing suicide prevention and early intervention strategies for youth, up to the age of 24 years, in schools, educational institutions, juvenile justice systems, substance use and mental health programs, foster care systems, pediatric health programs, and other child- and youth-serving organizations.
Technical Assistance Center for Mental Health Peer-Led Organizations
The purpose of this program is to provide training and technical assistance to increase the capacity of mental health peer-run organizations (PROs) which support adults with lived experience with serious mental illness. A PRO is an organization that is led and staffed primarily by people with lived experience of mental health challenges, also known as peers.
Innovation in Behavioral Health (IBH)
The Innovation in Behavioral Health (IBH) Model (the “Model”) for Cohort II Recipients is a seven-year, voluntary service delivery and payment model promoting integrated care in behavioral health (BH) settings. The IBH Model will test the impact of a value-based payment (VBP) model aligned across Medicaid and Medicare that supports an integrated care delivery framework in specialty BH organizations and settings for adult Medicaid, Medicare, and dually eligible beneficiaries with moderate to severe mental health conditions and/or substance use disorders (SUDs). The Centers for Medicare & Medicaid Services (CMS), through its Center for Medicare & Medicaid Innovation (Innovation Center), will select up to five state Medicaid agencies (SMAs) to participate in the Model. The Model will have a seven-year performance period, which will be comprised of a two-year Pre-Implementation Period (beginning January 2027 and ending December 2028) along with a five-year Implementation Period (beginning January 2029 and ending December 2033). Up to $7.5 million dollars in cooperative agreement award funding will be available to each selected Recipient over the course of the seven years.
A Demonstration to Scale Innovative Person-Centered Approaches to Falls Prevention through Clinical-Community Partnerships
The purpose of this funding announcement is to demonstrate and evaluate the scalability of person-centered and evidence-based approaches to falls prevention that leverage clinical and community partnerships and related data and technology tools. ACL intends to award a single cooperative agreement to one grantee for a three-year project period with the expectation that the grantee will fund up to three demonstrations. This award will build on the ACL Innovation Lab to demonstrate the scaling of person-centered and evidence-based approaches to falls prevention and related chronic disease management programs through community care hubs and their respective clinical partners and community-based organizations in the aging services network. The successful applicant will be expected to collaborate with ACL in the design and implementation of these demonstrations in the scalability of falls prevention and related chronic disease management interventions through approximately three advanced community care hubs that support care transitions and screening for the risk of falls. They should also have the capacity to 1) do rapid cycle evaluation to iterate and improve the impact of the interventions as they are scaled and, 2) administer sub-awards to community care hubs that can implement and scale person-centered interventions enabled by artificial intelligence, data analytics, assistive technology, virtual delivery of interventions, tools to support consumer behaviors, and related data infrastructure.
Grants for Adaptive Sports Programs for Disabled Veterans and Disabled Members of the Armed Forces (Adaptive Sports Grants)
The VA NVSPSE Program announces the availability of up to $16,000,000 (subject to the availability of Federal funds) for the VA Adaptive Sports Grant Program. VA will award grants to qualifying organizations to plan, develop, manage, and implement programs to provide adaptive sports, training, and other opportunities for Veterans and members of the Armed Forces with disabilities. Applications focused on equine therapy addressing the mental health needs of Veterans will not be considered under this NOFO and must be submitted to Funding Opportunity Number VA-EQUINE-26.
Grants for Adaptive Sports Programs for Disabled Veterans and Disabled Members of the Armed Forces (Equine Therapy Grants)
The VA NVSPSE Program announces the availability of up to $5,000,000 (subject to the availability of Federal funds) for the VA Adaptive Sports Grant Program's Equine Therapy Grants. VA will award grants to qualifying organizations to plan, develop, manage, and implement programs to provide adaptive sports, training, and other opportunities for Veterans and members of the Armed Forces with disabilities. Applications for general adaptive sports proposals not focused on addressing mental health issues through equine therapy will not be considered under this NOFO and must be submitted to Funding Opportunity Number VA-SPORTS-26.
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center
40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. § 241 and § 284.
Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions
The National Institute of Dental and Craniofacial Research (NIDCR) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that—individually, sequentially, or in combination—contribute to human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses, e.g., causal explanation and causal inference—rather than statistical association, also are encouraged. Project results should be poised for clinical trials translation to prevent, treat, and manage dental, oral, and craniofacial (DOC) and related conditions. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area of behavioral, biological, biopsychosocial, public, and social sciences are encouraged to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in dental, oral, craniofacial, and systemic health over the life course, including care and services, will be encouraged, and these investigators also should begin to consider applying. NIDCR is authorized to forecast this opportunity under the Public Health Service Act (42 U.S.C §§ 241 and 284) and federal regulations (42 CFR Part 52 and 2 CFR Part 200).
HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems
Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers. Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.
Notice of Intent to Publish a Funding Opportunity Announcement for Impact of Technology and Digital Media Exposure Usage on Child and Adolescent Development
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the impact of technology and digital media on children and adolescents. Technology and digital media (TDM) encompasses social media, applications, websites, television, motion pictures, artificial intelligence, mobile devices, computers, video games, virtual and augmented reality, and other content, networks, or platforms disseminated through the internet, broadcasted, or other media technologies, as applicable. Collectively, they have become an integral part of our children’s and families’ daily lives. Most children and adolescents now engage with TDM starting from an early age, often with high levels of exposure across multiple devices and contexts and involving a wide range of content. There is therefore an urgent need to understand how TDM use and exposure impacts children’s health and development, as well as how it alters the very nature of interactions between children and their family members, peers, and society at large. As TDM has evolved with breathtaking speed, our understanding of its impacts – whether positive, neutral, or negative – on children’s health and development has not kept pace. This initiative intends to address this expanding gap by inviting research proposals on the impact of TDM on children and adolescents, including potential broader effects on their families and communities. Please note that applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize a phased R61/R33 mechanism. Investigators with interests at the intersection of TDM and child/adolescent development are encouraged to apply. In addition, collaborative teams that combine expertise across domains such as behavioral sciences, cognition and learning, computational and statistical modeling, computer science, geographic information science, library and information sciences, neurodevelopment, pediatrics, social and affective development and social sciences will be encouraged, and these investigators should also consider applying for this opportunity.
Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with other NIH Institutes and Centers (ICs) - National Eye Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Deafness and Other Communication Disorders, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, and National Cancer Institute - intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the establishment and continuation of Genomic Curation Expert Panels that manually curate, review and define the clinical relevance of genes and variants as part of the NIH established and funded Clinical Genome Resource (ClinGen). Despite advances in genomic sequencing technology and increasing adoption in clinical practice, there are many genomic variants with unknown significance (VUS), and there is limited understanding of their function. This presents barriers to genomic and precision medicine. To address this need for better knowledge about the links between genes, variants, and disease, this NOFO will facilitate the development of Expert Panels to select genes and variants associated with diseases or conditions of high priority for participating NIH Institutes and Centers (ICs) and to systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions. The Expert Panels funded through this NOFO are required to utilize the NHGRI ClinGen and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure. Ultimately, these expert panels contribute to an authoritative, centralized, and public resource, through aggregation, evaluation, and sharing of expert-curated data about genetic conditions, and the variants that cause them.
Molecular, Neural, and Cognitive Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders
The National Institute on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to encourage basic research on Non-Invasive Brain Stimulation (NIBS) using animal and human models. NIBS techniques transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial focused ultrasound (tFUS) have emerged as promising approaches to treat addiction and substance use disorders (SUDs); however, their mechanisms of action are unclear. This initiative is to support research to (1) elucidate molecular, cellular, and circuit level changes induced by NIBS protocols (2) identify molecular mechanisms and pathways by which NIBS techniques and protocols produce their therapeutic effects in SUDs,(3) identify novel clinical targets for NIBS, and (4) investigate SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that may precede clinical outcomes. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into neuromodulation by non-invasive brain stimulation are encouraged to apply. In addition, collaborative investigations combining expertise in non-invasive brain stimulation and substance use and addiction are encouraged.
NIH Science Education Partnership Award (SEPA)
The NIH Science Education Partnership Award (SEPA) program supports innovative educational activities that encourage pre-college students (pre-kindergarten to grade 12), to pursue further studies in science, technology, engineering, and mathematics (STEM), particularly in the biomedical and behavioral sciences. The program will support classroom-based projects for pre-kindergarten to grade 12 (pre-college) students and teachers and informal science education (ISE) projects conducted in outside-the-classroom venues such as after-school science programs and libraries. Projects that support quantitative and computational skills development are strongly encouraged.
Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)
The National Institue on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on pioneering research in HIV and Substance use/substance use disorder (SUD) research. The Avant-Garde Award Program is designed to support exceptionally creative scientists who propose cutting edge high risk and high reward and possibly transformative approaches to major challenges in biomedical and behavioral research on HIV in the context of substance use and/or SUDs. This Program includes supporting early stage investigators (ESI). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the DP1 activity code. Investigators with expertise and insights into this area of substance use and HIV are encouraged to begin to consider applying for this new NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Data Analysis Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Administrative Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
Forecast to Publish a Funding Opportunity Announcement for Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
The National Institute on Drug Abuse (NIDA), with other NIH Institutes, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to support action-oriented research that accelerates the translation of addiction epidemiology, prevention, treatment, and recovery research to practice addressing both the opioid crisis and overdose events. Research supported under this initiative would focus on identifying and characterizing malleable factors and addressing barriers or facilitators to reducing substance use, misuse and overdose deaths at the individual, provider, organizational, community, or system levels. The emphasis would be on exploring and developing effective, replicable, and scalable approaches for accelerating the movement of evidence-based and promising treatments and preventive interventions into routine use. Specific priority areas would include, but not be limited to: recovery, prevention, pain/addiction intersections, engaging family and loved ones, transitions across care settings (e.g., inpatient treatment to community treatment), mental health integration, improving quality and efficiency of existing services and interventions, examining substance use and health outcomes and meaningful real-time data capture and use to improve services and public health approaches to reducing substance use, misuse, addiction, and overdose. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R61/R33 activity code. Investigators with expertise and insights into this area of addiction epidemiology, prevention, treatment, recovery and health services research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in modeling, health economics, implementation science, translation, or engagement science will be encouraged, and these investigators should also begin considering applying for this application.
HIV Prevention and Alcohol (R01 Clinical Trials Optional)
The NOFO seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. This includes integration of effective prevention and treatment interventions with an understanding of the overarching framework for reducing the incidence of new infections by facilitating cross-cutting informative research. This research activity includes the development and testing of new interventions and expansion of existing effective interventions as well as the implementation of these integrative preventive activities in a variety of settings and populations. Six areas of research are of primary interest related to alcohol use and related mental health and substance use comorbidities. These include but are not limited to 1) PrEP Utilization, 2) Treatment as Prevention (TasP), 3) Integration of Preventive Intervention Strategies, 4) Prevention-related Cross-cutting Research, 5) Syndemic Approaches and, 6) Implementation and Operations Research.
Health Equity Data Access Program (HEDAP)
The Health Equity Data Access program (HEDAP) provides funding for six (6) “seats” in the CMS Virtual Research Data Center (VRDC). The VRDC assists researchers in gaining access to CMS restricted data for minority health research. Seats, in this context are defined as an individual user with VRDC access. These researchers will conduct health services research on health care topics such as physical health, oral health, behavioral health, population health, and social determinants of health focusing on, but not limited to, racial and ethnic minority groups; people with disabilities; members of the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community; individuals with limited English proficiency; individuals residing in rural areas; and individuals (including children, youth, and families) adversely affected by persistent poverty or inequality. The HEDAP supports specific applied research projects that relate to creative and innovative methods utilizing CMS data to identify, document, assess, and evaluate health disparities among Medicare and Medicaid and CHIP enrollees. The project should enhance the capacity of the researcher to understand and utilize CMS data in future research projects. Additionally, HEDAP encourages cutting-edge proposals that explore intersectionality. “Intersectionality” means that people belong to more than one group and, therefore, may have overlapping health and social inequities, as well as overlapping strengths and assets. Results of the HEDAP will provide CMS and its partners, (e.g. Quality Improvement Organizations, Hospital Engagement Networks, and other stakeholders) with actionable information on the subgroups of enrollees. This will aid the efforts of CMS and its agents to identify and eradicate health disparities in underserved populations. VRDC seat access will be funded for a period of 36 months each, based on the availability of funds.
Identification of Drug-related and Formulation-Related Factors that Result in Alcohol Dose Dumping of Modified Release Oral Drug Products (U01) Clinical Trial Not Allowed
Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.