Care Coordination
Integrated care delivery, transitions, and coordination programs.
Supporting Interventions with Technical Assistance
The purpose of this funding opportunity is to fund one organization to implement and evaluate tailored technical assistance (TA) to Ryan White HIV/AIDS Program (RWHAP) recipients. The purpose of this initiative is to support the uptake of interventions by providing tailored, needs-based TA to RWHAP recipients and providers to address barriers to intervention start-up, such as competing priorities and not knowing how to adapt interventions to fit their organizational structures or client populations. By providing tailored TA and a one-time funding amount to cover start-up costs, RWHAP recipients and providers will be able to address these barriers and strengthen their ability to integrate and sustain innovative HIV care models. The adoption of these interventions across the HIV health care system will improve HIV health outcomes and reduce transmission of HIV. This funding opportunity is supported by the HRSA RWHAP Part F: Special Projects of National Significance (SPNS) Program. Funding supports an implementation science approach to adapt, implement, and evaluate the implementation of HIV care innovations. It also builds upon previous and current projects to increase the uptake of disseminated interventions that have been funded by HRSA’s HIV/AIDS Bureau (HAB). The proposed initiative will identify a representative set of RWHAP recipient and/or provider sites (up to 20 sites funded as subrecipients by the recipient, divided into two (2) phases) to receive short-term, tailored implementation support and resources to jump start efforts to adapt or replicate existing interventions. The recipient will work with the sites to understand their specific needs and organizational structure to develop tailored resources and TA to adapt or replicate selected emerging, evidence-informed, and evidence-based interventions and other HIV care innovations.
Assertive Community Treatment
The purpose of this program is to establish or expand ACT programs for transition-aged youth (age 18-25), adults, and older adults with a serious mental illness (SMI) including individuals with SMI who are experiencing homelessness or are at imminent risk of homelessness.
State Pilot Program for Treatment for Pregnant and Postpartum Women
The purpose of this program is to strengthen and expand integrated, evidence-based substance use disorder (SUD) and maternal mental health services for pregnant and postpartum women and their families. The program seeks to improve maternal and infant health outcomes by addressing SUD and co-occurring substance use and mental health conditions through comprehensive screening, treatment, recovery supports, and workforce development. Priority populations include pregnant and postpartum women with primary diagnoses of SUDs, including opioid use disorder, and co-occurring mental health conditions, their infants and families, and communities disproportionately impacted by maternal morbidity and mortality.
Promoting Integration of Primary and Behavioral Health Care: States
The purpose of this program is to: promote full integration and collaboration in clinical practices between physical and behavioral health care; support the improvement of integrated care models for physical and behavioral health care to improve overall wellness and physical health status; and promote the implementation and improvement of bidirectional integrated care services, including evidence-based or evidence-informed screening, assessment, diagnosis, prevention, treatment, and recovery services for mental and substance use disorders, and co-occurring physical health conditions and chronic diseases.
Grants to Expand Substance Use Disorder Treatment Capacity in Adult and Family Treatment Drug Courts
The purpose of this program is to expand substance use disorder (SUD) treatment and recovery support services in existing drug courts. Grant recipients will be required to implement a coordinated, multisystem approach that combines the legal authority of treatment drug courts with evidence-based SUD treatment services. Key stakeholders include the judiciary, prosecution, defense attorneys, probation services, law enforcement, mental health professionals, social service agencies, and treatment providers. The objective is to disrupt the recurring pattern of criminal behavior, substance use, and incarceration or other legal consequences.
Screening & Treatment for Maternal Mental Health and Substance Use Disorders (MMHSUD)
The MMHSUD Program helps improve maternal mental health and substance use disorder outcomes for pregnant and postpartum women by providing obstetric, primary care, and other maternal health providers with timely access to teleconsultation, training, and care coordination support including resource and referrals.
Public Health Strategies to Address Alzheimer's Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator
Alzheimer's disease, the most common form of dementia, is a progressive condition. It begins with mild memory loss and may lead to the inability to communicate or respond to one's environment. Its prevalence is rising with the aging U.S. population. In 2021, it was the 5th leading cause of death for those 65 and older, with death rates continuing to climb. The CDC Alzheimer's Disease Program, through the National Healthy Brain Initiative (HBI) and funded partners, promotes brain health, addresses cognitive impairment, and supports caregivers using evidence-based approaches. This funding opportunity aligns with the HBI Road Map Series (including the State and Local Road Map 2023–2027 and the Road Map for Indian Country) and fulfills the aims of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406). Funding Structure: Component 1: National Healthy Brain Initiative: Funds up to two (2) organizations to develop and implement public health strategies guided by the HBI Road Map Series. Funded organizations will: Develop evidence-informed training for health care and public health professionals on ADRD and caregiving. Expand the availability and use of public health surveillance data, including adaptation & revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline and caregiver optional modules. Facilitate the coordination of recipients and national partners to address ADRD. Funding range: $2,500,000 to $3,000,000 per 12-month budget period. Component 2: BOLD Public Health Centers of Excellence: Funds three (3) Centers, each specializing in one of three topic-specific areas: dementia risk reduction, early detection and management of dementia, or dementia caregiving. Centers will: Support the needs of the BOLD public health program and other public health agencies. Identify, disseminate, and promote best practices. Translate promising research into practical tools and resources. Increase professional education and develop materials to address specific individual needs to improve health outcomes. Funding range: $750,000 to $1,000,000 per 12-month budget period. Component 3: ADRD Public Health Adoption Accelerator. Funds up to two (2) organizations to serve as public health strategy adaptation accelerator programs. This means using dissemination and implementation of science to spread and put into practice effective public health strategies, tools, and resources to tackle ADRD. Organizations will: Collaborate with CDC and other organizations to create a prioritized list of ADRD approaches & strategies. Use proven strategies to engage partners, health care organizations, and policymakers to enhance uptake and implementation, accelerating the impact of ADRD efforts. Provide technical assistance to Component 1 & 2 recipients. Funding range: $750,000 - $1,200,000 per 12-month budget period. Applicants may apply for multiple components, but must submit a separate application per component.
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close gaps in health outcomes within the US population and increase health for all.Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, participant recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination. The application should also describe its approaches to increase community engagement from conceptual design of the intervention through implementation and sustainability, close gaps in health outcomes within the US population, and increase health for all.
Regional Pediatric Prevention Network
The purpose of this program is to support a Regional Pediatric Prevention Network (RPPN). The RPPN strengthens local and regional capacity to care for children during disasters and emergencies through community partnerships, coordinated pediatric preparedness, and dissemination of research-informed pediatric disaster care. The RPPN will include at least 10 children’s hospitals, or their university pediatric partners, funded through two primary awards. It will also include community partners working with these hospitals. Each of the 10 Children’s Hospital centers will advance pediatric emergency and disaster preparedness at the local, regional, and national levels, including for children with special health care needs and behavioral health concerns, children living in poverty, and children in rural, remote, and tribal areas.
Hereditary Hemorrhagic Telangiectasia (HHT) Center
The purpose of the Hereditary Hemorrhagic Telangiectasia (HHT) Center Program is to reduce illness and death related to HHT by partnering with clinical center to expand access and coordination of care; creating innovative strategies that support clinicians with identifying and diagnosing HHT cases; and developing a de-identified, aggregate patient data registry to better understand this rare disease and its treatment outcomes.
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit research applications for practice-based research centers to support interdisciplinary teams of mental health researchers to engage in high-impact studies that will significantly advance clinical practice and generate knowledge to fuel the transformation of mental health care in the United States. Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers support research projects aimed at the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders; (2) developing and testing empirically informed patient-, provider- and system-level interventions to improve mental health care access, engagement, continuity, efficiency, and quality; and (3) continuously improving the quality, impact, and durability of optimized interventions and health for individuals with or at risk for mental health problems, including those with serious mental illness. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive research projects. This NOFO will utilize the P50 activity code. Applications must propose research that maximizes synergies across various components of the mental health research ecosystem, including new discoveries in clinical research, transformative health care technologies, advances in information science, and new federal and state mechanisms for organizing mental health care. Applicants with interdisciplinary expertise, such as behavioral science, health information and data science, health systems engineering, decision science, implementation science, and related fields, whose practice-based research needs cannot be met through standard research project grant mechanisms, should consider applying to this NOFO. Applications are also expected to include research activities that facilitate the widespread sharing of data, methods, and resources to accelerate clinical research and to provide opportunities for graduate students, postdoctoral researchers, and early-career investigators to participate in interdisciplinary research-to-practice translational mental health research.
Staff Sergeant Fox Suicide Prevention Grant Program Funding Opportunity
Description: The Department of Veterans Affairs (VA) is announcing the availability of funds for new and renewing suicide prevention grants under the Staff Sergeant Fox Suicide Prevention Grant Program (SSG Fox SPGP) for services in Federal Fiscal Year (FY) 2027. The SSG Fox SPGP directs efforts to reduce Veteran suicide by awarding grants to community-based organizations to directly provide or coordinate the provision of primarily non-clinical suicide prevention services to eligible individuals and their families. Eligible individuals include certain Veterans and Active-Duty Service Members as defined by statute and regulations. Veteran suicide risk is reduced by services that improve mental health status, well-being, financial stability, and social support. Services provided by grantees may include case management, peer support, linkage to VA care and benefits, emergency clinical services, faith-based or innovative approaches. Most Veterans who die by suicide were not engaged with VA in the years prior to their deaths. This program addresses a critical gap by engaging and serving Veterans at risk for suicide who were previously out of VA’s reach and their family members. These grants support the President’s commitment to increase the excellence of and options for care, benefits, and services for veterans, as well as improve the delivery and quality of the Department's healthcare services in a more efficient and effective manner to support veterans, as demonstrated in Executive Order 14296 – Keeping Promises to Veterans and Establishing a National Center for Warrior Independence. This NOFO contains information concerning the SSG Fox SPGP, the grant application process, and the amount of funding available. For detailed program information and requirements, see 38 C.F.R. Part 78.
Nurse Education, Practice, Quality, and Retention - Transition to Practice Program (NEPQR-TPP)
The Nurse Education, Pracitce, Quality and Retention - Transition to Practice Program (NEPQR-TPP) aims to increase the nursing workforce and address the nursing shortage in rural and medically underserved communities, by supporting innovative educational and clinical training opportunities.
Expanding Financial Literacy and Empowerment: Increasing Awareness and Use of ABLE Accounts for Americans with Disabilities
This grant is funded under the Projects of National Significance (PNS) authorized by the Developmental Disabilities Assistance and Bill of Rights Act. Its purpose is to increase awareness, access, and use of ABLE (Achieving a Better Life Experience) accounts so that individuals with disabilities have the resources needed to better support their health and economic well-being and improve their economic security and mobility. Since 2015, the ABLE Act has authorized states and territories to establish tax-advantaged programs—ABLE accounts—that allow individuals with disabilities to save and invest money. These accounts may be used for qualified disability expenses, including education, food, housing, transportation, employment training, assistive technology, and health care. Beginning in January 2026, ABLE eligibility requirements were expanded to include individuals with an age of disability onset up to 46, increased from the previous limit of 26. As a result, an estimated 14 million people will be eligible for ABLE accounts, including approximately 1.2 million veterans. This expansion presents a significant opportunity to broaden outreach to individuals receiving Medicaid and Supplemental Security Income (SSI), as well as individuals with disabilities who are not enrolled in disability benefit programs, to help overcome barriers to achieving good health and meaningful employment. To advance these goals, the grant will support strategies such as coordinated marketing efforts at the national, state, and community levels; population-specific approaches implemented through partnerships with ACL grantees and community stakeholders; and a strengthened systems approach at the state level. ACL recognizes that ABLE-related supports can play a critical role in increasing economic security and mobility for individuals with disabilities.
Delta Rural Integrated Health Network Program
The Delta Rural Integrated Health Network Program seeks to improve healthcare delivery in the region by supporting the development of integrated health networks among rural hospitals, primary care clinics, behavioral health providers and other essential services.
Rural Community Health Support Program
The purpose of the Rural Community Health Support Program cooperative agreement is to develop, deliver, and coordinate nationally available technical assistance that supports community-based organizations and rural health stakeholders serving rural populations to improve and expand delivery and access to quality care for rural communities.
Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY) Existing Geographic Service Areas
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services). The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV, to directly remove barriers to care for the person with HIV, or to promote family stability.
Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding
The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services. The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV , to directly remove barriers to care for the person with HIV, or to promote family stability. The purpose of this supplemental funding is to strengthen organizational capacity to respond to the changing health care landscape and increase access to high quality family-centered HIV primary health care services for low-income women, infants, children and youth (WICY) with HIV. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.
Rural Communities Opioid Response Program (RCORP)-Impact
The Rural Communities Opioid Response Program (RCORP)–Impact funds rural communities to drive measurable improvements in access to integrated, coordinated treatment and recovery services for substance use disorder (SUD), including opioid use disorder (OUD). Its long-term aim is to reduce morbidity and mortality associated with SUD and enable sustained recovery and well-being. The program supports: New or expanded evidence-based SUD prevention, treatment, and recovery services in rural areas;Coordination across health and supportive social services to enable sustained, long-term recovery;A larger, more responsive workforce to address SUD-related needs; andMulti-sector community networks to strengthen and sustain local service delivery.The focus of RCORP-Impact is on reducing the impact of opioid misuse on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Therefore, RCORP-Impact supports a comprehensive approach to address all SUD, including OUD, within a continuum of mental, behavioral, and related social supports.
Sickle Cell Disease Regional Care Excellence (SoRCE) Program
Sickle Cell Disease Regional Care Excellence Program (SoRCE) is to improve the health of people with sickle cell disease (SCD) by expanding access to care, improving the quality of care, and tracking quality of life indicators. There are approximately 100,000 people in the United States with SCD. Treatment starting in early childhood can prevent or reduce complications such as severe pain episodes, silent strokes, and premature death. Despite universal identification at birth, fewer than half of children with SCD receive needed treatment. As these children become adolescents and transition to adulthood many are not appropriately identified as candidates for disease-modifying therapies, in part because their doctors are still learning how to use the latest treatments. The program is made up of seven regions with one award recipient per region serving as a Regional Coordinating Hub (RCH). Each award recipient will work with clinical and community-based partners in their region and engage in continuous quality improvement (CQI) initiatives to improve access and quality of care.
Rural Health Network Advancement Program
The Rural Health Network Advancement Program is a pilot initiative to support networks comprised of independent rural hospitals and clinics in integrated network collaboration. It bridges support to offset small scale structural barriers that make it difficult for rural providers to compete in an increasingly consolidated health care system landscape and is designed to help bring economic efficiencies to small independent rural entities by expanding and enhancing their ability to strengthen operations, preserve existing services, and build new lines of care through integrated network collaboration that preserves local autonomy.
Pediatric Mental Health Care Access Program (PMHCA)
The Pediatric Mental Health Care Access (PMHCA) program helps improve mental and behavioral health for children and youth by giving pediatric primary care providers quick access to tele-consultation, training, and care coordination support.
National Center for Child Traumatic Stress - Category 1
The purpose of the National Child Traumatic Stress Initiative (NCTSI) - Category I National Center for Child Traumatic Stress program is to create/maintain the national coordinating center that serves the NCTSI network.
Strengthening and modernizing Uganda's sustainable public health systems and workforce in data science, informatics, and surveillance to produce timely, accurate, and integrated data for action
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $30,000,000 for Year 1, subject to the availability of funds. This NOFO supports the Ministry of Health (MOH)-led digital transformation vision to modernize Uganda’s health data systems and infrastructure. It also supports enhancing capacity to provide timely epidemic intelligence for critical decision-making in HIV and related health programs. The data architecture is expected to encompass: General and targeted surveys.Clinical systems such as electronic medical records (EMR).Digital registers.Clinical indicator-based surveillance.Disease surveillance.Laboratory data.Commodities, logistics, and pharmacy management information systems.Community data.Human resource management and development.Other data collection activities to address existing data and knowledge gaps. The NOFO also supports developing digital solutions and strengthening data warehousing, integration, and interoperability to build a sustainable and resilient digital ecosystem ready for transition to local governance.
Innovation in Behavioral Health (IBH)
The Innovation in Behavioral Health (IBH) Model (the “Model”) for Cohort II Recipients is a seven-year, voluntary service delivery and payment model promoting integrated care in behavioral health (BH) settings. The IBH Model will test the impact of a value-based payment (VBP) model aligned across Medicaid and Medicare that supports an integrated care delivery framework in specialty BH organizations and settings for adult Medicaid, Medicare, and dually eligible beneficiaries with moderate to severe mental health conditions and/or substance use disorders (SUDs). The Centers for Medicare & Medicaid Services (CMS), through its Center for Medicare & Medicaid Innovation (Innovation Center), will select up to five state Medicaid agencies (SMAs) to participate in the Model. The Model will have a seven-year performance period, which will be comprised of a two-year Pre-Implementation Period (beginning January 2027 and ending December 2028) along with a five-year Implementation Period (beginning January 2029 and ending December 2033). Up to $7.5 million dollars in cooperative agreement award funding will be available to each selected Recipient over the course of the seven years.
Providing technical support and capacity building for the Government of Mozambique and local organizations for life-saving HIV and TB and public health care services in the Republic of Mozambique
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $15,000,000 for Year 1, subject to the availability of funds. This NOFO is intended to support the Government of the Republic of Mozambique (GRM) expand life-saving HIV and TB and other health services throughout the country. It focuses on improving the approach to technical support and capacity building to transition to GRM provincial directorate-led HIV and TB service in line with the goals laid out by the Mozambique Ministry of Health (MISAU) and the U.S. government (USG). This NOFO is expected to strengthen existing capabilities and provide technical support for sustainable direct service delivery (DSD) of integrated life-saving HIV and TB services in Mozambique. This includes support for national-level activities like MISAU’s capacity building for technical guidelines, policy, and training curricula development, and updates. This NOFO is expected to also address gaps in human resources for health (HRH) at the national and provincial level. This includes developing and implementing training for healthcare staff and using novel training platforms, such as virtual modalities and tele-medicine.
Engaging faith-based organizations to sustain lifesaving HIV and TB services in Ethiopia
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $5,000,000 for Year 1, subject to the availability of funds. This NOFO will engage faith-based organizations (FBOs) to support and sustain lifesaving HIV, TB, and cervical cancer services in Ethiopia. HIV services will include: • HIV testing. • HIV prevention, including vertical transmission. • Adult and pediatric HIV care and treatment. Through this project, you will work with faith communities to provide and link people with lifesaving HIV services. You will serve: • People at high risk of acquiring HIV. • Undiagnosed people living with HIV • People living with HIV at risk of interrupting their treatment. • Pregnant and breastfeeding women. • People living with HIV who may face barriers to accessing conventional health facility services. You will be expected to implement cost-efficient models and integrate them with the routine health-care delivery system to reach undiagnosed people living with HIV, people living with HIV who have defaulted from care, and people at high risk of acquiring HIV, ensuring their access to critical, lifesaving HIV and TB services. This NOFO will support activities that promote country ownership and country-led plans that enable greater sustainability. Programs supporting other public health threats and emergencies in Ethiopia may also be included in this NOFO.
Improving regional capacity to respond to HIV, TB, and other global health priorities in Central America
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $20,000,000 for Year 1, subject to the availability of funds. You will advance progress towards achieving the 95-95-95 targets and continue to transition site-level support to local governments in Central America (CA) for: El Salvador.Guatemala.Honduras.Nicaragua.Panama.To achieve the goals of this NOFO, you will address gaps in: HIV prevention.Diagnosis.Life-saving treatment.Proposed activities should facilitate country ownership while improving local capacity to: Make sure HIV prevention is available for populations most at risk, through the Sentinel Surveillance of STI and HIV Strategy (VICITS).Provide testing that leads to active linkage to HIV treatment and prevention services.Improve early HIV diagnosis through active case-finding strategies, including:Testing as outreach for populations most at risk for HIV.Index, provider-initiated, and community testing.Social network strategy.Self-testing.Support the integration of comprehensive care and treatment services, including for HIV, TB, and other opportunistic infections.Build capacity of healthcare workers to provide high-quality health services led by the country, and through continuous quality improvement (CQI) initiatives.Make sure adequate data systems are used to monitor progress toward 95-95-95 targets and other global health priorities.Support sustainable health systems that improve:Efficiency.Country ownership of the program.Global health security to fight priority infectious diseases and other public health threats.
Enhancing sustainable health information and laboratory systems and networks for quality detection, management, and monitoring to end HIV and TB as public health threats in India
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $6,000,000 for Year 1, subject to the availability of funds. CDC invites proposals to support India’s Ministry of Health and Family Welfare (MOHFW), National AIDS Control Organization (NACO), and related institutions to strengthen health systems and laboratory networks for HIV, TB, and other public health concerns. It aligns with the America First Global Health Strategy (AFGHS) to bolster health systems to prevent the global spread of infectious disease. You should enhance innovative, cost-effective, and quality-assured laboratory services for HIV, TB, and related health programs by focusing on early detection, service delivery, and monitoring in priority regions. Strategic support will foster ownership, integrate broader health systems, and align with U.S. global health priorities. Activities include: Optimizing health information and laboratory networks for HIV, TB, and co-infections to enhance access, early detection, and boost capacity for other public health concerns.Enhancing surveillance of infectious disease threats by integrating national data systems for coordinated public health action.Reinforcing biosafety, biosecurity, and laboratory quality systems.Adopting innovative technologies to meet disease containment goals.Supporting molecular diagnostics and epidemiology to track transmission networks and drug resistance for infectious diseases, focusing on HIV and co-infections.Strengthening the health workforce to collect, analyze, and use data to improve patient care, feedback systems, and epidemic trend monitoring.
A Demonstration to Scale Innovative Person-Centered Approaches to Falls Prevention through Clinical-Community Partnerships
The purpose of this funding announcement is to demonstrate and evaluate the scalability of person-centered and evidence-based approaches to falls prevention that leverage clinical and community partnerships and related data and technology tools. ACL intends to award a single cooperative agreement to one grantee for a three-year project period with the expectation that the grantee will fund up to three demonstrations. This award will build on the ACL Innovation Lab to demonstrate the scaling of person-centered and evidence-based approaches to falls prevention and related chronic disease management programs through community care hubs and their respective clinical partners and community-based organizations in the aging services network. The successful applicant will be expected to collaborate with ACL in the design and implementation of these demonstrations in the scalability of falls prevention and related chronic disease management interventions through approximately three advanced community care hubs that support care transitions and screening for the risk of falls. They should also have the capacity to 1) do rapid cycle evaluation to iterate and improve the impact of the interventions as they are scaled and, 2) administer sub-awards to community care hubs that can implement and scale person-centered interventions enabled by artificial intelligence, data analytics, assistive technology, virtual delivery of interventions, tools to support consumer behaviors, and related data infrastructure.
Strengthening Aging Services for Minority Populations Through Technical Assistance, Resource Development, and Program Coordination
The Older Americans Act (OAA) requires that services and supports it funds be targeted to older adults and their family caregivers that are in greatest economic and greatest social need. The Strengthening Aging Services for Minority Populations Through Technical Assistance, Resource Development, and Program Coordination will fund one (1) National Minority Technical Assistance Resource Center (TARC) that will serve the national aging network. This 3-year (36 month) cooperative agreement will focus on strengthening the national capacity to address the multi-faceted needs of a older adults and their family caregivers. Outcomes of the project will include: 1. Developing and disseminating training and technical assistance in areas such as (but not limited to) economic security, access to services, housing needs, self-advocacy, family and caregiver supports, and trauma informed approaches. 2. Educating the aging network on effective strategies and resources for engaging older adults who face barriers to receiving adequate outreach and access. 3. Providing evidence-based approaches, community engagement techniques, and resources to ensure all older adults receive the attention and services they deserve. 4. Developing, testing and disseminating approaches that aging and human services network agencies can employ to more successfully work one-on-one with minority older adults, their families, and family caregivers.
Lifespan Respite Care Program: Grants to New States and States Re-Establishing Their Core Respite Infrastructures
ACL is seeking applications from eligible state agencies that will establish, or reestablish, state and local coordinated Lifespan Respite Care systems and deliver respite care and related services to family caregivers of children and adults across all age groups, disabilities, and chronic conditions as defined in the statute. Funds supplement, not replace existing funds. Eligible states applying must fall within one of the following two categories: 1) New States that have not previously received a grant under this program. 2) Returning States who have had at least one (1) Lifespan Respite Care Program grant, but whose programs have gone dormant or lapsed since federal funding ended, and desire to re-establish their core state respite infrastructures, rather than apply for a Program Enhancement grant. ACL will fund approximately four (4) cooperative agreements for the 3-year project period. All programs must, from the outset, address the respite needs of all populations regardless of age, disability, or chronic condition of the care recipient population. Funded applicants shall use grant funds to serve all age groups and disabilities, provide new and emergency care services, recruit and train workers and volunteers, help families access care services and other authorized services as outlined in the Act. It is ACL’s expectation that all grantees will, no later than the second and third years of the grant project period, provide respite services while continuing to build their statewide respite infrastructure. Awardees under this funding opportunity will work with ACL to implement the data collection and reporting requirements under Section 2904 of the Lifespan Respite Reauthorization Act of 2020.
Advancing Whole-Person Health: Enhancing Networks of Community-Based Aging and Disability Organizations to Improve Access to Long-Term Services and Supports
ACL intends to award a single cooperative agreement to one grantee for a three-year project period. This award will support a regional community care hub (CCH) scaling strategy to expand access to long-term services and supports (LTSS) for older adults and people with disabilities as part of a broader No Wrong Door System effort. The successful applicant will be expected to collaborate with ACL to support approximately three regional advanced CCHs to enable CCH scaling through shared infrastructure services and alignment with existing CCHs and other community-based aging and disability organizations. They should also have the capacity to provide technical assistance to the selected super hubs as they work to expand their infrastructure capacity to support streamlined access to LTSS through health care payer partnerships, with services inclusive of care transitions, care coordination, and evidence-based prevention/health promotion programs.
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center
40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. § 241 and § 284.
Expanding Global Health Security through local partnerships in Senegal
This NOFO aims to enhance Senegal's public health infrastructure to prevent, detect, and respond to infectious disease threats through implementing partners. The initiative focuses on strengthening public health surveillance systems, including community-based surveillance, improving laboratory networks, and enhancing workforce training. The goal is to build sustainable, resilient health security infrastructure, aligning with Global Health Security Agenda (GHSA) objectives. Partners will collaborate to promote cross-sectoral coordination and foster innovative approaches.
Strengthening global health security in India to contain public health threats and accelerate outbreak response
This NOFO’s purpose is to support district, state and national public health systems in India to advance GHSA priorities to prevent, detect and respond to infectious disease threats. CDC will work with the Government of India (GoI) to strengthen capacity to control disease outbreaks at their source and neutralize public health threats. This NOFO will augment and increasingly transition CDC-supported GHSA initiatives to GoI institutions including the National Centre for Disease Control, National Health Mission, Indian Council of Medical Research, National Disaster Management Authority, National Institute of Disaster Management and All Indian Institute of Medical Science. The core aim is to enhance India’s public health capacity through a One Health approach in alignment with the International Health Regulations in five key areas: 1) public health workforce; 2) disease surveillance; 3) laboratory systems; 4) emergency preparedness and response; and 5) antimicrobial resistance.
Centers for Independent Living Competition - Guam
ACL intends to award funds for the establishment of one (1) center for independent living in Guam to provide, expand and improve the provision of independent living services and support the network of centers for independent living. At a minimum, centers funded by the program are required to provide the following core services: information and referral; independent living skills training; peer counseling; individual and systems advocacy; and services that facilitate transition from nursing homes and other institutions to the community, assistance to those at risk of entering institutions and facilitate the transition of youth to postsecondary life. The estimated total funding amount to be awarded to establish a center for independent living in Guam is $159,762. Twenty-four-month project period with two 12-month budget periods.
Centers for Independent Living Competition - American Samoa
ACL intends to award funds for the establishment of one (1) center for independent living in American Samoa to provide, expand and improve the provision of independent living services and support the network of centers for independent living. At a minimum, centers funded are required to provide the following core services: information and referral; independent living skills training; peer counseling; individual and systems advocacy; and services that facilitate transition from nursing homes and other institutions to the community, assistance to those at risk of entering institutions and facilitate the transition of youth to postsecondary life. The estimated total funding amount to be awarded to establish a center for independent living in American Samoa is $159,762. Twenty-four-month project period with two 12-month budget periods.
Addressing Dementia in Tribal and Urban Indian Communities: CAReS Program
This Notice of Funding Opportunity (NOFO) supports Tribal and Urban Indian communities in strengthening dementia care and services for American Indian and Alaska Native (AI/AN) people. Rooted in Indigenous values and community self-determination, the program will fund meaningful, measurable improvements that span the full dementia care continuum, from early recognition to caregiver support. Option A – Dementia CAReS (Care Access, Resources, and Support). One national awardee will coordinate four integrated priorities: Mini-Project Funding to help clinics launch culturally tailored services. A Dementia Champion Network connecting frontline leaders. Success Sharing through case studies and toolkits. Evaluation & Data using common performance measures and dashboards. Option B – Dementia Caregiver Support and Training Center. One national awardee will deliver dementia caregiver support training, services, resources, and technical assistance. Services will support Tribes, Tribal organizations, and Urban Indian organizations. The awardee will develop and implement a comprehensive, culturally relevant caregiver support and training model. It will prioritize leadership and advocacy, caregiver support, and knowledge and skills development. Across both options, recipients will document emerging practices using standardized measures. These measures will guide continuous quality improvement and improve outcomes for AI/AN people and their caregivers. Across both options, recipients will document emerging practices using standardized measures. These measures will guide continuous quality improvement and improve outcomes for AI/AN people and their caregivers. Funding range for Option A (CAReS) per applicant for the first budget period: $500,000 to $750,000 Funding range for Option B (Caregiver Support) per applicant for the first budget period: $250,000 - $300,000 We expect to fund projects in 5 one-year budget periods for a total period of performance of 5 years.
Retail Food Safety Regulatory Association Collaboration
The program furthers the FDA's support of state, local, tribal, and territorial (SLTT) retail food safety programs in their efforts to reduce the occurrence of food-borne illness risk factors for the benefit of the public. Recipients of this funding will assist SLTT agencies in conducting research, implementing intervention strategies, and performing other activities to reduce the occurrence of food-borne illness risk factors, reduce the burden of foodborne illness, and advance a nationally integrated food safety system.
Novel approaches to support therapeutic development in ultra-rare cancers
The purpose of this program is to support new approaches that can be applied to facilitate therapeutic development in ultra-rare pediatric and adult cancers, including molecularly-defined subsets of more common cancers. Specific areas of interest include, but are not limited to, the following examples: • Development of infrastructure for a coordination network and data repository for patient-level data across institutions and internationally to support drug development and regulatory decision-making for one or more ultra-rare cancers. • Investigations to explore opportunities to develop and validate early clinical endpoints and other novel efficacy endpoints for evaluation of treatments for ultra-rare cancers. • Development and implementation of a collaborative multi-stakeholder effort to support generation and use of real-world data leveraging a registry framework for use in development of new therapies for pediatric patients with diffuse midline glioma (DMG) (including diffuse intrinsic pontine glioma, DIPG). • Innovative approaches to identify new biologically-driven opportunities for clinical development of previously approved drugs or biologics (hereafter referred to as drugs), including drugs for which development has been discontinued, in ultra-rare cancers. • Research to develop novel approaches to preserve the availability of drugs for which commercial developers have discontinued adult development that have strong potential in ultra-rare cancers but lack financial incentives for commercial development • Development of methods to incorporate use of telemedicine and/or pragmatic trial design elements (e.g., collecting laboratory and/or imaging data from local facilities) for patient assessments to facilitate enrollment of patients with ultra-rare cancers • Development of nanoparticle-based delivery approaches for therapeutic nucleic acids targeting onco-fusion transcription factors in metastatic tumor animal models using targeted bioPROTAC degradation or genomic editing strategies. Successful efforts should demonstrate effective delivery and expression in-vivo to tumor cells, and downregulation of the target transcription factor protein while minimizing off-target effects and limiting sequestration of the nanoparticle by the liver, spleen, and lungs. • Research to exhaustively characterize the plasma-membrane protein expression (surfaceome) of an ultra-rare cancer and the presumed healthy tissue of origin, as well as the resident-tissue stem cells, by single-cell transcriptomics and proteomics. These studies, and available correlative database analyses, should be designed to identify possible combinatorial signatures of plasma membrane proteins unique to the ultra-rare tumor. Tumors of interest include Sclerosing epithelioid fibrosarcoma and atypical teratoid rhabdoid tumors (ATRT).
Agriculture and Food Research Initiative Competitive Grants Program Foundational and Applied Science Program
The AFRI Foundational and Applied Science Program supports grants in six AFRI priority areas to advance knowledge in both fundamental and applied sciences important to agriculture. The six priority areas are: Plant Health and Production and Plant Products; Animal Health and Production and Animal Products; Food Safety, Nutrition, and Health; Bioenergy, Natural Resources, and Environment; Agriculture Systems and Technology; and Agriculture Economics and Rural Communities. Research-only, extension-only, and integrated research, education and/or extension projects are solicited in this Request for Applications (RFA). See Foundational and Applied Science RFA for specific detail.
HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems
Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers. Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Data Analysis Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Administrative Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
Forecast to Publish a Funding Opportunity Announcement for Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
The National Institute on Drug Abuse (NIDA), with other NIH Institutes, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to support action-oriented research that accelerates the translation of addiction epidemiology, prevention, treatment, and recovery research to practice addressing both the opioid crisis and overdose events. Research supported under this initiative would focus on identifying and characterizing malleable factors and addressing barriers or facilitators to reducing substance use, misuse and overdose deaths at the individual, provider, organizational, community, or system levels. The emphasis would be on exploring and developing effective, replicable, and scalable approaches for accelerating the movement of evidence-based and promising treatments and preventive interventions into routine use. Specific priority areas would include, but not be limited to: recovery, prevention, pain/addiction intersections, engaging family and loved ones, transitions across care settings (e.g., inpatient treatment to community treatment), mental health integration, improving quality and efficiency of existing services and interventions, examining substance use and health outcomes and meaningful real-time data capture and use to improve services and public health approaches to reducing substance use, misuse, addiction, and overdose. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R61/R33 activity code. Investigators with expertise and insights into this area of addiction epidemiology, prevention, treatment, recovery and health services research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in modeling, health economics, implementation science, translation, or engagement science will be encouraged, and these investigators should also begin considering applying for this application.
GPD Grant Forecast
THIS IS NOT A NOTICE OF FUNDING. THIS IS A GENERAL FORECAST ONLY. Grant and Per Diem (GPD) Program Introduction The GPD Program is VA’s largest transitional housing program for Veterans experiencing homelessness and is permanently authorized under Public Law 109-461. Since 1994, the GPD Program has awarded grants to community-based organizations to provide transitional housing with wraparound supportive services to assist vulnerable Veterans move into permanent housing. The grants are designed to meet Veterans at various stages as they move to stable housing. Community-based organizations receiving GPD grants offer focused transitional housing services through a variety of housing models targeted to different populations and needs of Veterans. The GPD program plays a vital role in the continuum of homeless services by providing supportive services to those Veterans who would otherwise be among the unsheltered homeless population. The result of GPD programs is that Veterans achieve residential stability, increase their skill levels and/or income, and obtain greater self-determination. Types of GPD Grants Transitional housing grants: Per Diem Only (PDO) grants provide funding in the form of per diem payments to reimburse grantees for the cost of care provided to Veterans in transitional supportive housing. Special Need grants target housing and services to specific populations of Veterans (e.g., women, Veterans with chronic mental illness, frail elderly Veterans, Veterans caring for minor dependents, terminally ill Veterans). Transition-In-Place (TIP) grants offer Veteran residents housing in which supportive services transition out of the residence over time, rather than the resident. Upon completion of the TIP services, the resident retains the unit as their permanent housing with no requirement to move. Other types of grants: Case Management grants support Veterans who were previously experiencing homelessness or who are at risk for homelessness so that they may obtain or retain permanent housing. Capital grants support the costs of acquiring, renovating, or constructing facilities and are only offered intermittently to improve existing facilities or to develop new transitional housing depending on VA's priorities and funding availability. Lists of current grantees are available on the GPD website. How to Apply for GPD Funding Not all grant types are available annually. When available, notices of funding can be found at the following locations: www.grants.gov and https://www.va.gov/homeless/gpd.asp. Application instructions are provided in each notice of funding. Each notice of funding will clarify specific eligibility criteria, application requirements, funding limitations, and other requirements. Applications are submitted through an online portal that is only available when there is an open notice of funding. Potential applicants who wish to see what was required for previous applications may review past notices of funding, available on the GPD provider website and www.grants.gov. Past notices of funding are not a guarantee of future requirements. Tentative Estimated GPD Award Schedule Specific dates are not able to be forecast. The follow tentative approximations are provided for general planning purposes. FY 2026 Case Management – GPD tentatively expects to offer a notice of funding around FY 2025 for case management awards starting approximately in FY 2026. FY 2027 PDO – GPD tentatively expects to offer a notice of funding around FY 2026 for PDO awards starting approximately in FY 2027. TIP – GPD tentatively expects to offer a notice of funding around FY 2026 for TIP awards starting approximately in FY 2027. FY 2028 GPD tentatively does not expect to offer a notice of funding for this timeframe. GPD may update this forecast closer to the time. THIS IS NOT A NOTICE OF FUNDING. THIS IS A GENERAL FORECAST ONLY.
Research to Advance the Science of Primary Care (R01)
The purpose of this Notice of Funding Opportunity (NOFO) is to build evidence about the characteristics and value of primary care that influence patient outcomes and advance health equity, such as care coordination, continuity of care, and comprehensiveness of care, person-centered, whole healthcare, and trust, and how these can be improved and effectively delivered to strengthen primary healthcare.
AHRQ Small Health Services Research Grant Program (R03)
purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others.
AHRQ Health Services Research Projects (R01)
The purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others.
AHRQ Health Services Research Demonstration and Dissemination Grants (R18)
The purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others.
Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed
The intended outcome of this Notice of Funding Opportunity (NOFO) is to advance efforts for a nationally Integrated Food Safety System (IFSS) by supporting Manufactured Food Regulatory Program Standards (MFRPS), Food Protection Task Force (FPTF) programs, Dietary Supplement (DS) programs, and special projects. For the purposes of this NOFO, the term state encompasses all eligible organizations as defined in Section 3. MFRPS Development or Maintenance: The purpose of this Notice of Funding Opportunity (NOFO) section is to advance efforts for a nationally Integrated Food Safety System (IFSS) by assisting state manufactured food regulatory programs to achieve and maintain conformance with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS). The MFRPS are intended to ensure that state manufactured food regulatory programs implement a high-quality regulatory program through the development and maintenance of a regulatory framework that builds on and emphasizes mutual reliance with all programs. Also, the program standards are intended to enhance food safety by establishing a uniform basis for measuring and improving the performance of manufactured food regulatory programs in the United States. Conformance with these program standards will help federal and state programs better direct their regulatory activities at reducing foodborne illness hazards in plants that manufacture, process, pack, or hold foods. Food Protection Task Force (FPTF): The purpose of this funding option is to establish and/or support a Food Protection Task Force (FPTF) with diverse membership representative of stakeholders across the state that is responsible for promoting the integration of an efficient statewide human and animal food (HAF) protection system that addresses state and region-specific needs and that maximize the protection of the public health. These efforts include: establishing a food safety/protection network of subject matter experts, fostering educational opportunities, developing replicable resources and systematically fostering communication, education, outreach, cooperation and collaboration within the states among federal, state, local, tribal and territorial HAF protection, public health, agriculture, and regulatory agencies, industry, academia, and consumers to initiate and/or support HAF protection activities to improve public health. A strong FPTF can also help improve human and animal food emergency surveillance, response, and post-response systems by focusing on preparedness, building strong communication channels, and establishing relationships with key players before food-related incidents occur. Dietary Supplements: The goal of this funding option is to facilitate the development of state driven dietary supplement regulatory framework and programs. The overall objective of this funding opportunity is to advance the adoption and implementation of the cGMPs for Dietary Supplements Rule codified at 21 CFR Part 111. Specifically, this track will provide funding support for dietary supplement training and program development activities. Special Projects: The purpose of this funding option is to develop and implement special projects that support innovation and integration in a IFSS using the MFRPS framework. This track will support other emerging food safety priorities that develop over the lifespan of the project. State programs will be expected to share project deliverables and resources developed with other programs.
NHLBI Program Project Applications (P01 Clinical Trials Optional)
The National Heart, Lung, and Blood Institute (NHLBI) Program Project Grant (P01) supports research related to fundamental processes and diseases of the heart, blood and lymphatic vessels, lungs, and blood, including transfusion medicine, blood resources, and sleep disorders other programs including implementation science, health disparities, and translation research that address the mission of the Institute. This FOA requires a minimum of three interrelated research projects that investigate a complex biomedical theme or research question. The projects may be supported by core units, if justified, to facilitate economy of effort, space, and equipment. The NHLBI provides support for Program Project Grants (PPGs) in the belief that collaborative research efforts can accelerate the acquisition of knowledge more effectively than a simple aggregate of research projects that have no interaction or thematic integration. NHLBI is particularly interested in encouraging new scientific directions in PPGs. Use of the P01 activity code is viewed as an opportunity to attract scientists who have not traditionally been supported by the NHLBI. Further, the PPG environment presents an opportunity for emerging scientific leaders to gain insight into how to lead a successful scientific Program, and applicants will have the opportunity to include a project led by an Early Stage Investigator (ESI). All projects in the Program must be interrelated and have objectives that address a central theme within the scientific mandate of the NHLBI.
Integrating Machine Learning with Computational Fluid Dynamics Models of Orally Inhaled Drug Products (U01) Clinical Trials Not Allowed
Computational fluid dynamics (CFD) has played a crucial role in providing an alternative bioequivalence (BE) approach for generic orally inhaled drug products (OIDPs), in addition to comparative clinical endpoint or pharmacodynamic BE studies, as a relatively cost- and time-efficient complement to benchtop and clinical experiments that has been widely used in developing and assessing generic inhaler devices. However, despite the advances in the power of modern computers, there are still some bottlenecks in using CFD due to computational time, limited grid resolution, pre- and post-processing of large simulation data sets, model parameter estimations, and uncertainty quantifications. Machine learning (ML) has been gaining more attention as a potential tool to alleviate such limitations that arise in CFD. The purpose of this grant is to develop a methodology to integrate ML with CFD models of OIDPs to promote alternative BE studies to enhance and accelerate the development and approval of generic OIDPs.