Network Development
Collaborative networks, coalitions, and multi-site programs.
Promoting Integration of Primary and Behavioral Health Care: States
The purpose of this program is to: promote full integration and collaboration in clinical practices between physical and behavioral health care; support the improvement of integrated care models for physical and behavioral health care to improve overall wellness and physical health status; and promote the implementation and improvement of bidirectional integrated care services, including evidence-based or evidence-informed screening, assessment, diagnosis, prevention, treatment, and recovery services for mental and substance use disorders, and co-occurring physical health conditions and chronic diseases.
Statewide Consumer Network
The purpose of this program is to strengthen the capacity and sustainability of statewide mental health peer-run organizations.
Statewide Family Network
The purpose of this program is to enhance the capacity of statewide, mental health family-controlled organizations to support, train, and mentor family members/primary caregivers.
Promoting Cancer Surveillance Workforce, Education, and Data Use
This NOFO will implement educational activities to support the registry workforce, establish and maintain collaborations with cancer partners, and develop tools to support and enhance data quality and completeness. These efforts will expand registrars’ capacity, enhance recruitment and retention, and promote cancer surveillance data. The bolstering of the cancer registrar workforce will strengthen NPCR registries’ capacity to comply with Public Law 102-515, the Cancer Registries Amendment Act, and submit timely, accurate, and complete cancer data.
Public Health Strategies to Address Alzheimer's Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator
Alzheimer's disease, the most common form of dementia, is a progressive condition. It begins with mild memory loss and may lead to the inability to communicate or respond to one's environment. Its prevalence is rising with the aging U.S. population. In 2021, it was the 5th leading cause of death for those 65 and older, with death rates continuing to climb. The CDC Alzheimer's Disease Program, through the National Healthy Brain Initiative (HBI) and funded partners, promotes brain health, addresses cognitive impairment, and supports caregivers using evidence-based approaches. This funding opportunity aligns with the HBI Road Map Series (including the State and Local Road Map 2023–2027 and the Road Map for Indian Country) and fulfills the aims of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer’s Act (P.L. 115-406). Funding Structure: Component 1: National Healthy Brain Initiative: Funds up to two (2) organizations to develop and implement public health strategies guided by the HBI Road Map Series. Funded organizations will: Develop evidence-informed training for health care and public health professionals on ADRD and caregiving. Expand the availability and use of public health surveillance data, including adaptation & revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline and caregiver optional modules. Facilitate the coordination of recipients and national partners to address ADRD. Funding range: $2,500,000 to $3,000,000 per 12-month budget period. Component 2: BOLD Public Health Centers of Excellence: Funds three (3) Centers, each specializing in one of three topic-specific areas: dementia risk reduction, early detection and management of dementia, or dementia caregiving. Centers will: Support the needs of the BOLD public health program and other public health agencies. Identify, disseminate, and promote best practices. Translate promising research into practical tools and resources. Increase professional education and develop materials to address specific individual needs to improve health outcomes. Funding range: $750,000 to $1,000,000 per 12-month budget period. Component 3: ADRD Public Health Adoption Accelerator. Funds up to two (2) organizations to serve as public health strategy adaptation accelerator programs. This means using dissemination and implementation of science to spread and put into practice effective public health strategies, tools, and resources to tackle ADRD. Organizations will: Collaborate with CDC and other organizations to create a prioritized list of ADRD approaches & strategies. Use proven strategies to engage partners, health care organizations, and policymakers to enhance uptake and implementation, accelerating the impact of ADRD efforts. Provide technical assistance to Component 1 & 2 recipients. Funding range: $750,000 - $1,200,000 per 12-month budget period. Applicants may apply for multiple components, but must submit a separate application per component.
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close gaps in health outcomes within the US population and increase health for all.Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Regional Pediatric Prevention Network
The purpose of this program is to support a Regional Pediatric Prevention Network (RPPN). The RPPN strengthens local and regional capacity to care for children during disasters and emergencies through community partnerships, coordinated pediatric preparedness, and dissemination of research-informed pediatric disaster care. The RPPN will include at least 10 children’s hospitals, or their university pediatric partners, funded through two primary awards. It will also include community partners working with these hospitals. Each of the 10 Children’s Hospital centers will advance pediatric emergency and disaster preparedness at the local, regional, and national levels, including for children with special health care needs and behavioral health concerns, children living in poverty, and children in rural, remote, and tribal areas.
Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit research applications for practice-based research centers to support interdisciplinary teams of mental health researchers to engage in high-impact studies that will significantly advance clinical practice and generate knowledge to fuel the transformation of mental health care in the United States. Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers support research projects aimed at the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders; (2) developing and testing empirically informed patient-, provider- and system-level interventions to improve mental health care access, engagement, continuity, efficiency, and quality; and (3) continuously improving the quality, impact, and durability of optimized interventions and health for individuals with or at risk for mental health problems, including those with serious mental illness. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive research projects. This NOFO will utilize the P50 activity code. Applications must propose research that maximizes synergies across various components of the mental health research ecosystem, including new discoveries in clinical research, transformative health care technologies, advances in information science, and new federal and state mechanisms for organizing mental health care. Applicants with interdisciplinary expertise, such as behavioral science, health information and data science, health systems engineering, decision science, implementation science, and related fields, whose practice-based research needs cannot be met through standard research project grant mechanisms, should consider applying to this NOFO. Applications are also expected to include research activities that facilitate the widespread sharing of data, methods, and resources to accelerate clinical research and to provide opportunities for graduate students, postdoctoral researchers, and early-career investigators to participate in interdisciplinary research-to-practice translational mental health research.
Make America Healthy Again – Enhancing Lifestyle and Evaluating Value-based Approaches Through Evidence
The Centers for Medicare & Medicaid Services (CMS), through its Centers for Medicare and Medicaid Innovation (CMMI or Innovation Center), is soliciting applications for the Make America Healthy Again: Enhancing Lifestyle & Evaluating Value-based Approaches Through Evidence (MAHA ELEVATE) Model. This voluntary, three-year service delivery model is designed to test evidence-based, whole-person functional or lifestyle medicine (“whole-person FLM”) approaches to care. Rather than treating diseases separately after they develop, MAHA ELEVATE takes a proactive, comprehensive approach that combines psychological, nutritional, and physical interventions with personalized, lifestyle-based strategies for prevention and early treatment. Throughout this NOFO, we use the term “whole-person FLM” to represent a range of services or approaches often incorporated in lifestyle and functional medicine that are not currently covered under Medicare. It is important to clarify that CMS is not establishing a new industry standard through the use of this terminology. The term “whole-person FLM” as used in this NOFO does not represent an attempt by CMS to create, define, or establish any new industry-wide standard, practice guideline(s), or healthcare delivery model beyond the scope of this specific Innovation Center model and funding opportunity. Similarly, through this funding opportunity, CMS is not creating a new category of covered services for Medicare purposes. This term serves solely as a descriptive reference within this document to facilitate clear communication about the non-covered services being tested in this model and should not be interpreted as having any regulatory, coverage, or policy implications beyond the context of this specific Innovation Center model. CMS will select a total of up to 30 Recipients to participate in MAHA ELEVATE. The model will be split into two cohorts, one year apart (years 2026 and 2027). CMS will select recipients based on five key criteria: • Whole-person FLM intervention design, including cost savings. • Beneficiary recruitment and study design. • Organizational and administrative capacity. • Data management capabilities. • Budget. Highly competitive applicants must demonstrate several important strengths: • Strong, evidence-based support for your proposed intervention(s) and proof of your own successful history of implementation of the intervention and cost savings. • Ability to recruit large numbers of participants with a clear randomization plan and advanced data management capabilities. Given the model’s minimum beneficiary targets and extensive data management requirements, applicants who do not directly provide clinical care are strongly encouraged to form partnerships with care entities or organizations that deliver clinical care. This collaboration helps ensure you can meet the full operational requirements of the program.
Drug-Free Communities (DFC) Support Program – NEW (Year 1)
The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2026 Drug-Free Communities (DFC) Support Program grants. The purpose of the DFC Support Program is to establish and strengthen collaboration to support the efforts of community coalitions working to prevent youth substance use. By statute, the DFC Support Program has two goals: 1) Establish and strengthen collaboration among communities, public and private non-profit agencies, as well as federal, state, local, and tribal governments to support the efforts of community coalitions working to prevent and reduce substance abuse among youth (individuals 18 years of age and younger). 2) Reduce substance abuse among youth and, over time, reduce substance abuse among adults by addressing the factors in a community that increase the risk of substance abuse and promoting the factors that minimize the risk of substance abuse.
Drug-Free Communities (DFC) Support Program – COMPETING CONTINUATION (Year 6)
The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2026 Drug-Free Communities (DFC) Support Program Grants. The purpose of the DFC Support Program is to establish and strengthen collaborations to support the efforts of community coalitions working to prevent and reduce substance use among youth. By statute, the DFC Support Program has two goals: 1) Establish and strengthen the collaboration among communities, public and private non-profit agencies, as well as federal, state, local, and tribal governments to support the efforts of community coalitions working to prevent and reduce substance use among youth (individuals 18 years of age and younger). 2) Reduce substance use among youth and, over time, reduce substance use among adults by addressing the factors in a community that increase the risk of substance use and promoting the factors that minimize the risk of substance use. This funding opportunity will fund applicants who have concluded the first (Year 1 – 5) funding cycle or have experienced a lapse in funding.
Strategies to Link, Engage, and Retain Men with HIV in Care: Evaluation Provider
The purpose of this funding opportunity is to award one cooperative agreement recipient to serve as the Evaluation Provider (EP). This funding opportunity has a companion funding opportunity to fund an Implementation Technical Assistance Provider (ITAP). The two recipients will work collaboratively, but conduct distinct activities that support the overall initiative. The proposed initiative will be comprised of one Evaluation Provider (EP), one Implementation Technical Assistance Provider (ITAP) funded as a separate cooperative agreement, and up to eight (8) implementation sites sub-awarded by the ITAP. This initiative will use implementation science to adapt, implement, and evaluate the implementation of interventions that serve men with HIV who are not consistently engaged in care or experiencing barriers to staying in care This initiative directly aligns with Ryan White Program 2030 (RWP2030), which is a renewed vision for the Ryan White HIV/AIDS Program (RWHAP). Building on the foundation of the RWHAP and the Ending the HIV Epidemic in the U.S. initiative, the RWP2030 framework is designed to sustain high-quality care and treatment for people currently receiving services through the RWHAP while expanding efforts to identify and engage individuals with HIV who are undiagnosed or out-of-care. The funded Evaluation Provider (EP) will lead a multi-site evaluation of the project and will provide evaluation-specific technical assistance (TA) to the implementation sites. The evaluation activities that the EP will conduct will draw from frameworks and approaches developed in the field of implementation science, including HAB’s Implementation Science Framework. The initiative emphasizes: 1) rapid adaptation, implementation, and evaluation; 2) implementation at a broad scale to produce generalizable findings; 3) public release of dissemination products based on human-centered design and adult learning principles, which foregrounds sustainability, rapid dissemination of findings, and replication of best practices.
Strategies to Link, Engage, and Retain Men with HIV in Care: Implementation Technical Assistance Provider
The purpose of this funding opportunity is to award one cooperative agreement recipient to serve as the Implementation Technical Assistance Provider (ITAP). This funding opportunity has a companion funding opportunity to fund an Evaluation Provider. The two recipients will work collaboratively, but conduct distinct activities that support the overall initiative. The proposed initiative will be comprised of one Implementation Technical Assistance Provider (ITAP), which will sub-award up to eight (8) implementation sites. The funded ITAP will solicit and select the implementation sites, as well as to identify emerging and evidence-informed interventions to be adapted and implemented by the implementation sites. The ITAP will be responsible for managing the subawards and providing implementation-specific technical assistance (TA) for the implementation sites. The proposed initiative will use implementation science to adapt, implement, and evaluate the implementation of interventions that serve men with HIV who are not consistently engaged in care or experiencing barriers to staying in care. This initiative directly aligns with Ryan White Program 2030 (RWP2030), which is a renewed vision for the Ryan White HIV/AIDS Program (RWHAP). Building on the foundation of the RWHAP and the Ending the HIV Epidemic in the U.S. initiative, the RWP2030 framework is designed to sustain high-quality care and treatment for people currently receiving services through the RWHAP while expanding efforts to identify and engage individuals with HIV who are undiagnosed or out-of-care. The funded ITAP will manage the subawards, identify emerging and evidence-informed interventions to be adapted and implemented by the implementation sites, and provide implementation-specific TA to the implementation sites. The adaptation and implementation activities the ITAP will conduct will draw from frameworks and approaches developed in the field of implementation science including HAB’s Implementation Science Framework. The initiative emphasizes: 1) rapid adaptation, implementation, and evaluation; 2) implementation at a broad scale to produce generalizable findings; 3) public release of dissemination products based on human-centered design and adult learning principles, which foregrounds sustainability, rapid dissemination of findings, and replication of best practices.
Delta Rural Integrated Health Network Program
The Delta Rural Integrated Health Network Program seeks to improve healthcare delivery in the region by supporting the development of integrated health networks among rural hospitals, primary care clinics, behavioral health providers and other essential services.
Comprehensive Addiction and Recovery Act (CARA)
The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2026 Comprehensive Addiction and Recovery Act (CARA) Community-based Coalition Enhancement Grants to Address Local Drug Crises Grants (CARA Local Drug Crises Grants) as an enhancement to current or formerly funded Drug-Free Communities (DFC) Support Program recipients. The purpose of this program is to prevent and reduce the use of opioids and methamphetamines and the misuse of prescription drugs among youth ages 12-18 in communities throughout the United States.
BJA FY25 Public Safety and Mental Health Initiative
This NOFO supports comprehensive service networks addressing untreated mental illness and substance use at the intersection of mental health, substance use, and justice systems. This program responds to the growing burden of endemic vagrancy, disorderly behavior and public safety threats faced by law enforcement agencies. These agencies are often positioned as first responders to situations better addressed by health and social service systems. Law enforcement and justice agencies nationwide need actionable alternatives that prioritize both public order and appropriate treatment settings for those experiencing mental illness or substance use disorders. Specifically, this initiative provides funding to support activities through four core areas: (1) crisis stabilization centers; (2) treatment services; (3) housing access; and (4) electronic health record (EHR) systems and technology modernization.
Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials
The National Institute on Drug Abuse seeks to support pilot and feasibility studies in preparation for efficacy, effectiveness and/or services research trials. Topics may include:1) developing interventions to prevent substance use, misuse or progression to disorder, 2) substance use prevention, treatment or recovery services research, including comorbid pain, medical and mental health disorders, 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations. Projects may address information gaps, strengthen stakeholder partnerships, or pilot test interventions. Activities might include intervention development/adaptation; assessing intervention or service model acceptability and feasibility; and development of measures, materials, or methods for the future trial. Preliminary data is not required. A well-defined theory of change or logic model is expected. Applicants must engage relevant end users in study design, execution, and interpretation (e.g., policymakers, state and local decision makers, practitioners, individuals with lived/living experience, families, youth, and community members). Applications are not being solicited at this time. This notice is to allow applicants time to develop collaborations and responsive projects. Grant authorities that allow this forecast are 42 U.S.C. §§ 241 and 284.
Technology-enabled Collaborative Learning Program
The Technology-enabled Collaborative Learning Program will support the use of technology-enabled collaborative learning to improve retention of health care providers and increase access to health care services in rural and underserved areas and populations.
Telehealth Nutrition Services Network Grant Program
The Telehealth Nutrition Services Network Grant Program will support telehealth networks that improve access to quality health care services through telehealth technology. This program will focus on chronic disease prevention and chronic disease management through comprehensive telehealth nutrition services.
Rural Communities Opioid Response Program (RCORP)-Impact
The Rural Communities Opioid Response Program (RCORP)–Impact funds rural communities to drive measurable improvements in access to integrated, coordinated treatment and recovery services for substance use disorder (SUD), including opioid use disorder (OUD). Its long-term aim is to reduce morbidity and mortality associated with SUD and enable sustained recovery and well-being. The program supports: New or expanded evidence-based SUD prevention, treatment, and recovery services in rural areas;Coordination across health and supportive social services to enable sustained, long-term recovery;A larger, more responsive workforce to address SUD-related needs; andMulti-sector community networks to strengthen and sustain local service delivery.The focus of RCORP-Impact is on reducing the impact of opioid misuse on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Therefore, RCORP-Impact supports a comprehensive approach to address all SUD, including OUD, within a continuum of mental, behavioral, and related social supports.
Rural Health Network Advancement Program
The Rural Health Network Advancement Program is a pilot initiative to support networks comprised of independent rural hospitals and clinics in integrated network collaboration. It bridges support to offset small scale structural barriers that make it difficult for rural providers to compete in an increasingly consolidated health care system landscape and is designed to help bring economic efficiencies to small independent rural entities by expanding and enhancing their ability to strengthen operations, preserve existing services, and build new lines of care through integrated network collaboration that preserves local autonomy.
Adult Suicide Prevention
The purpose of this program is to implement suicide prevention and intervention programs for adults, 18 years of age or older. This is accomplished by taking a broad-based public health approach to suicide prevention through enhanced collaboration with key community stakeholders, raising awareness of available suicide prevention resources, and implementing lethal means safety.
Project AWARE (Advancing Wellness and Resiliency in Education)
The purpose of Project AWARE is to develop a sustainable infrastructure for school-based mental health programs and services. Award recipients should build collaborative partnerships with the State Education Agency, Local Education Agency, Tribal Education Agency, the State Mental Health Agency, community-based providers of behavioral health care services, school personnel, community organizations, families, and school-aged youth.
National Center for Child Traumatic Stress - Category 1
The purpose of the National Child Traumatic Stress Initiative (NCTSI) - Category I National Center for Child Traumatic Stress program is to create/maintain the national coordinating center that serves the NCTSI network.
Centers for AIDS Research (CFAR)
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for the Centers for AIDS Research (CFAR). The national network of CFARs cooperates with other HHS-funded HIV/AIDS programs to establish and maintain the collaborations and infrastructure required to carry out innovative implementation science research for ending the HIV epidemic domestically. Addressing a complex chronic disease, HIV/AIDS research requires broad scientific expertise, access to unique biological samples, and cutting-edge research technologies that extend beyond the needs of individual research groups. The CFAR program strengthens HIV/AIDS research by providing infrastructure that fosters multidisciplinary collaborations, maximizes efficiencies by reducing duplication of efforts, and leverages economies of scale to facilitate the translation of basic research findings into new HIV treatment, prevention, and cure approaches. A core mission of the CFAR program is to support and mentor early-career investigators and investigators new to HIV/AIDS research by funding pilot studies, emerging research opportunities, and high-risk/high-impact collaborative studies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Implementation Science to End the HIV Epidemic
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for implementation science to end the HIV epidemic. Projects will leverage research-community collaborations to bring evidence-based advances in HIV prevention, diagnosis, treatment, and cluster outbreak response to communities disproportionately impacted by HIV. The goals of these projects will be to: (1) Develop strategies to end HIV by integrating innovations across disciplines such as epidemiology, data science, public health, medicine, social services, implementation science, and community engagement, and (2) Deploy, test, and evaluate new or existing strategies at multiple geographic locations or settings. While deployment of these strategies will occur at the local scale, through partnerships with, local, state, and federal public health partners, the overall program will advance generalized knowledge that informs larger scale efforts to end HIV. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Sustaining life-saving HIV services in Ukraine by strengthening resilient health systems under the Ukraine Ministry of Health, Public Health Center
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $10,000,000 for Year 1, subject to the availability of funds. This NOFO aims to help the Public Health Center (PHC) of the Ministry of Health (MOH) enhance life-saving assistance for HIV and associated prevalent health conditions. This should be accomplished with targeted HIV testing, prevention, and treatment activities amid ongoing instability. The objectives of this NOFO include: Working to ensure that targeted HIV testing, treatment, retention, and prevention services are widely available for people who are at higher risk for HIV. Services should be provided in community settings using social network strategies (SNS). Activities include:Targeted community-based case finding.Immediate linkage to available treatment.Retention support.Management of advanced HIV disease and HIV/TB co-infection.Improving the availability of HIV services by mobile HIV testing, treatment, and prevention. You should use targeted mobile HIV case finding, treatment, retention, and prevention services. Activities include:Streamlining immediate linkage to treatment.Strengthening ongoing adherence support.Improving the availability and quality of HIV services at medical facilities by implementing differentiated service delivery (DSD) models. Activities include enhancing patients’ retention, adherence, and access to HIV services at the facility level.Enhancing essential, targeted HIV prevention service provision for people at higher risk for HIV, focusing on availability, quality, coverage and timely initiation.
Improving regional capacity to respond to HIV, TB, and other global health priorities in Central America
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $20,000,000 for Year 1, subject to the availability of funds. You will advance progress towards achieving the 95-95-95 targets and continue to transition site-level support to local governments in Central America (CA) for: El Salvador.Guatemala.Honduras.Nicaragua.Panama.To achieve the goals of this NOFO, you will address gaps in: HIV prevention.Diagnosis.Life-saving treatment.Proposed activities should facilitate country ownership while improving local capacity to: Make sure HIV prevention is available for populations most at risk, through the Sentinel Surveillance of STI and HIV Strategy (VICITS).Provide testing that leads to active linkage to HIV treatment and prevention services.Improve early HIV diagnosis through active case-finding strategies, including:Testing as outreach for populations most at risk for HIV.Index, provider-initiated, and community testing.Social network strategy.Self-testing.Support the integration of comprehensive care and treatment services, including for HIV, TB, and other opportunistic infections.Build capacity of healthcare workers to provide high-quality health services led by the country, and through continuous quality improvement (CQI) initiatives.Make sure adequate data systems are used to monitor progress toward 95-95-95 targets and other global health priorities.Support sustainable health systems that improve:Efficiency.Country ownership of the program.Global health security to fight priority infectious diseases and other public health threats.
Enhancing sustainable health information and laboratory systems and networks for quality detection, management, and monitoring to end HIV and TB as public health threats in India
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $6,000,000 for Year 1, subject to the availability of funds. CDC invites proposals to support India’s Ministry of Health and Family Welfare (MOHFW), National AIDS Control Organization (NACO), and related institutions to strengthen health systems and laboratory networks for HIV, TB, and other public health concerns. It aligns with the America First Global Health Strategy (AFGHS) to bolster health systems to prevent the global spread of infectious disease. You should enhance innovative, cost-effective, and quality-assured laboratory services for HIV, TB, and related health programs by focusing on early detection, service delivery, and monitoring in priority regions. Strategic support will foster ownership, integrate broader health systems, and align with U.S. global health priorities. Activities include: Optimizing health information and laboratory networks for HIV, TB, and co-infections to enhance access, early detection, and boost capacity for other public health concerns.Enhancing surveillance of infectious disease threats by integrating national data systems for coordinated public health action.Reinforcing biosafety, biosecurity, and laboratory quality systems.Adopting innovative technologies to meet disease containment goals.Supporting molecular diagnostics and epidemiology to track transmission networks and drug resistance for infectious diseases, focusing on HIV and co-infections.Strengthening the health workforce to collect, analyze, and use data to improve patient care, feedback systems, and epidemic trend monitoring.
A Demonstration to Scale Innovative Person-Centered Approaches to Falls Prevention through Clinical-Community Partnerships
The purpose of this funding announcement is to demonstrate and evaluate the scalability of person-centered and evidence-based approaches to falls prevention that leverage clinical and community partnerships and related data and technology tools. ACL intends to award a single cooperative agreement to one grantee for a three-year project period with the expectation that the grantee will fund up to three demonstrations. This award will build on the ACL Innovation Lab to demonstrate the scaling of person-centered and evidence-based approaches to falls prevention and related chronic disease management programs through community care hubs and their respective clinical partners and community-based organizations in the aging services network. The successful applicant will be expected to collaborate with ACL in the design and implementation of these demonstrations in the scalability of falls prevention and related chronic disease management interventions through approximately three advanced community care hubs that support care transitions and screening for the risk of falls. They should also have the capacity to 1) do rapid cycle evaluation to iterate and improve the impact of the interventions as they are scaled and, 2) administer sub-awards to community care hubs that can implement and scale person-centered interventions enabled by artificial intelligence, data analytics, assistive technology, virtual delivery of interventions, tools to support consumer behaviors, and related data infrastructure.
Strengthening Aging Services for Minority Populations Through Technical Assistance, Resource Development, and Program Coordination
The Older Americans Act (OAA) requires that services and supports it funds be targeted to older adults and their family caregivers that are in greatest economic and greatest social need. The Strengthening Aging Services for Minority Populations Through Technical Assistance, Resource Development, and Program Coordination will fund one (1) National Minority Technical Assistance Resource Center (TARC) that will serve the national aging network. This 3-year (36 month) cooperative agreement will focus on strengthening the national capacity to address the multi-faceted needs of a older adults and their family caregivers. Outcomes of the project will include: 1. Developing and disseminating training and technical assistance in areas such as (but not limited to) economic security, access to services, housing needs, self-advocacy, family and caregiver supports, and trauma informed approaches. 2. Educating the aging network on effective strategies and resources for engaging older adults who face barriers to receiving adequate outreach and access. 3. Providing evidence-based approaches, community engagement techniques, and resources to ensure all older adults receive the attention and services they deserve. 4. Developing, testing and disseminating approaches that aging and human services network agencies can employ to more successfully work one-on-one with minority older adults, their families, and family caregivers.
Spinal Cord Injury Model Systems Centers
The SCIMS program is designed to provide research-based knowledge to support a multidisciplinary system of rehabilitation care for people with spinal cord injury (SCI). For purposes of this program, SCI is defined as a clinically discernible degree of neurologic impairment of the spinal cord. SCIMS Centers must conduct site-specific and collaborative research. SCIMS Centers must also collect and contribute data to the SCIMS longitudinal database. SCIMS Centers will be funded at varying amounts up to the maximum award based on the numbers of database participants eligible for follow-up in the SCIMS longitudinal database. Existing centers with significantly larger numbers of database participants will receive higher funding within the specified range, as determined by NIDILRR after the applicants are selected for funding. The grant will have a 60-month project period, with five 12-month budget periods.
ACL National Resource Center on Nutrition and Aging
The purpose of this Notice of Funding Opportunity is to support one organization through a cooperative agreement to serve as the National Resource Center on Nutrition and Aging. This center will act as a central connector to the aging network for the discretionary and formula funded nutrition grants. It will offer individualized and tiered technical assistance, high-quality education, and a wide range of resources. The Resource Center will help the network provide cost-effective services that align with the purposes of the Older Americans Act, Title III-C. They will help promote the advancement of the Senior Nutrition Program network by building partnerships, supporting data collection, reporting metrics, highlighting key achievements, and engaging stakeholders to encourage long-term sustainability of the Senior Nutrition Programs.
Disability and Rehabilitation Research Projects (DRRP) Program: Model Systems Knowledge Translation Center
The purpose of NIDILRR's Disability and Rehabilitation Research Project (DRRP) grants is to improve the effectiveness of services authorized under the Rehabilitation Act by generating knowledge or developing methods, procedures, and rehabilitation technologies that advance a wide range of independent living and employment outcomes for individuals with disabilities, especially those with the greatest support needs. Under this particular opportunity, a DRRP must conduct knowledge translation and related activities in collaboration with the Burn Model System, Spinal Cord Injury (SCI) Model System, and Traumatic Brain Injury (TBI) Model System grantees. Specifically, the MSKTC will be required to collaborate with the model system centers to produce and promote systematic reviews of existing research and information products for SCI, TBI, and Burn; identify and implement effective strategies for disseminating SCI, TBI, and Burn Model System programs’ research findings; serve as the central resource for the Model System programs' knowledge and product dissemination; and provide training and technical assistance in knowledge translation for the Model System grantees. This grant will have a 60-month project period, with five 12-month budget periods.
ACL National Falls Prevention Resource Center
The purpose of this Notice of Funding Opportunity is to support one organization through a cooperative agreement to serve as the National Falls Prevention Resource Center. This center will act as a central connector to the aging network for the discretionary and formula funded Falls Prevention grants. It will offer individualized and tiered technical assistance, high-quality education, and a wide range of resources to increase the number of older adults and adults with disabilities who participate in evidence based Falls Prevention Programs. The Resource Center will help the network provide cost-effective services that align with the purposes of the Older Americans Act, Title III-D. They will promote the advancement of the Falls Prevention network through building partnerships, supporting data collection, reporting metrics, highlighting key achievements, and engaging stakeholders to encourage long-term sustainability of the programs.
Spinal Cord Injury (SCI) Model Systems National Data and Statistical Center
The purpose of NIDILRR's Disability and Rehabilitation Research Project (DRRP) grants is to improve the effectiveness of services authorized under the Rehabilitation Act by generating knowledge or developing methods, procedures, and rehabilitation technologies that advance a wide range of independent living and employment outcomes for individuals with disabilities, especially those with the greatest support needs. This Center will advance medical rehabilitation by increasing the rigor and efficiency of scientific efforts to longitudinally assess the experiences and outcomes of individuals with spinal cord injury (SCI). This Center must maintain the national longitudinal database for data submitted by each of the SCI Model Systems Centers. This Center must also ensure collection of high quality data, and support rigorous research by the Model Systems centers by monitoring data quality, providing training in the collection of SCI Model Systems data, providing methodological consultation to these centers, and other collaborative tasks. The grant will have a 60-month project period, with five 12-month budget periods.
Traumatic Brain Injury Model Systems National Data and Statistical Center
The purpose of NIDILRR's Disability and Rehabilitation Research Project (DRRP) grants is to improve the effectiveness of services authorized under the Rehabilitation Act by generating knowledge or developing methods, procedures, and rehabilitation technologies that advance a wide range of independent living and employment outcomes for individuals with disabilities, especially those with the greatest support needs. This Center will advance medical rehabilitation by increasing the rigor and efficiency of scientific efforts to longitudinally assess the experiences and outcomes of individuals with traumatic brain injury (TBI). This Center must maintain the national longitudinal database for data submitted by each of the TBI Model Systems Centers. This Center must also ensure collection of high quality data, and support rigorous research by the Model Systems centers by monitoring data quality, providing training in the collection of TBI Model Systems data, providing methodological consultation to these centers, and other collaborative tasks. The grant will have a 60-month project period, with five 12-month budget periods.
Advancing Strategies to Enhance Preventative Health to Older Adults in the Senior Nutrition Program
The purpose of this Notice of Funding Opportunity is to support a statewide initiative that will develop the capacity to increase the number of older adults who participate in senior nutrition program with preventative health focus. Project goals include, 1) through a statewide initiative, develop the capacity to increase the number of older adults who participate in the senior nutrition program, 2) to develop resources that can be shared to the network to enhance knowledge and sustainability of these programs, and 3) increase partnerships and collaboration between senior nutrition programs, organizations that focus on older adults and other key partners.
Advancing Whole-Person Health: Enhancing Networks of Community-Based Aging and Disability Organizations to Improve Access to Long-Term Services and Supports
ACL intends to award a single cooperative agreement to one grantee for a three-year project period. This award will support a regional community care hub (CCH) scaling strategy to expand access to long-term services and supports (LTSS) for older adults and people with disabilities as part of a broader No Wrong Door System effort. The successful applicant will be expected to collaborate with ACL to support approximately three regional advanced CCHs to enable CCH scaling through shared infrastructure services and alignment with existing CCHs and other community-based aging and disability organizations. They should also have the capacity to provide technical assistance to the selected super hubs as they work to expand their infrastructure capacity to support streamlined access to LTSS through health care payer partnerships, with services inclusive of care transitions, care coordination, and evidence-based prevention/health promotion programs.
Lifespan Respite Care Program: State Program Enhancement Grants
ACL is seeking applications from eligible state agencies that will advance the provision of respite services through their statewide Lifespan Respite Care system as outlined in the Act. Eligible states applying must use funds to enhance respite services through their existing Lifespan Respite Care system and have already received a program enhancement grant and looking to continue to scale and build collaborations and partnerships. Funds supplement, not replace existing funds. The goal of the program is to enhance state systems and capacities to deliver respite care and related services to family caregivers of children and adults across all age groups, disabilities, and chronic conditions. All programs must, from the outset, address the respite needs of all populations regardless of age, disability, or chronic condition of the care recipient population. Funded applicants will continue advancing goals that build collaborations and partnerships statewide, expand volunteer options, offer respite provider training, find and reduce service gaps through outreach and engagement, and further meaningful caregiver-focused strategies and authorized services as outlined in the Act. ACL will fund approximately ten (10) cooperative agreements over the course of the 3-year project period. Awardees under this funding opportunity will work with ACL to implement the data collection and reporting requirements under Section 2904 of the Lifespan Respite Reauthorization Act of 2020.
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center
40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. § 241 and § 284.
Expanding Global Health Security through local partnerships in Senegal
This NOFO aims to enhance Senegal's public health infrastructure to prevent, detect, and respond to infectious disease threats through implementing partners. The initiative focuses on strengthening public health surveillance systems, including community-based surveillance, improving laboratory networks, and enhancing workforce training. The goal is to build sustainable, resilient health security infrastructure, aligning with Global Health Security Agenda (GHSA) objectives. Partners will collaborate to promote cross-sectoral coordination and foster innovative approaches.
Centers for Independent Living Competition - Guam
ACL intends to award funds for the establishment of one (1) center for independent living in Guam to provide, expand and improve the provision of independent living services and support the network of centers for independent living. At a minimum, centers funded by the program are required to provide the following core services: information and referral; independent living skills training; peer counseling; individual and systems advocacy; and services that facilitate transition from nursing homes and other institutions to the community, assistance to those at risk of entering institutions and facilitate the transition of youth to postsecondary life. The estimated total funding amount to be awarded to establish a center for independent living in Guam is $159,762. Twenty-four-month project period with two 12-month budget periods.
Centers for Independent Living Competition - American Samoa
ACL intends to award funds for the establishment of one (1) center for independent living in American Samoa to provide, expand and improve the provision of independent living services and support the network of centers for independent living. At a minimum, centers funded are required to provide the following core services: information and referral; independent living skills training; peer counseling; individual and systems advocacy; and services that facilitate transition from nursing homes and other institutions to the community, assistance to those at risk of entering institutions and facilitate the transition of youth to postsecondary life. The estimated total funding amount to be awarded to establish a center for independent living in American Samoa is $159,762. Twenty-four-month project period with two 12-month budget periods.
Addressing Dementia in Tribal and Urban Indian Communities: CAReS Program
This Notice of Funding Opportunity (NOFO) supports Tribal and Urban Indian communities in strengthening dementia care and services for American Indian and Alaska Native (AI/AN) people. Rooted in Indigenous values and community self-determination, the program will fund meaningful, measurable improvements that span the full dementia care continuum, from early recognition to caregiver support. Option A – Dementia CAReS (Care Access, Resources, and Support). One national awardee will coordinate four integrated priorities: Mini-Project Funding to help clinics launch culturally tailored services. A Dementia Champion Network connecting frontline leaders. Success Sharing through case studies and toolkits. Evaluation & Data using common performance measures and dashboards. Option B – Dementia Caregiver Support and Training Center. One national awardee will deliver dementia caregiver support training, services, resources, and technical assistance. Services will support Tribes, Tribal organizations, and Urban Indian organizations. The awardee will develop and implement a comprehensive, culturally relevant caregiver support and training model. It will prioritize leadership and advocacy, caregiver support, and knowledge and skills development. Across both options, recipients will document emerging practices using standardized measures. These measures will guide continuous quality improvement and improve outcomes for AI/AN people and their caregivers. Across both options, recipients will document emerging practices using standardized measures. These measures will guide continuous quality improvement and improve outcomes for AI/AN people and their caregivers. Funding range for Option A (CAReS) per applicant for the first budget period: $500,000 to $750,000 Funding range for Option B (Caregiver Support) per applicant for the first budget period: $250,000 - $300,000 We expect to fund projects in 5 one-year budget periods for a total period of performance of 5 years.
Epidemiology Program for American Indian/Alaska Native Tribes and Urban Indian Communities
The purpose of this NOFO is to strengthen public health capacity of 1) Tribal Epidemiology Centers (TECs) and 2) the Tribes, Tribal Organizations, Urban Indian organizations, and Intertribal Consortiums that they support to fulfill the seven functions of TECs as outlined in the Indian Health Care Improvement Act (IHCIA) at 25 U.S.C. 1621m(b). It is the intent of IHS to fund sufficient TECs to serve Tribes and Urban Indian communities in all 12 IHS administrative areas and serving the Urban population as a consolidated Area. Applicant objectives may include activities beyond the required activities but must address all required activities.
Retail Food Safety Regulatory Association Collaboration
The program furthers the FDA's support of state, local, tribal, and territorial (SLTT) retail food safety programs in their efforts to reduce the occurrence of food-borne illness risk factors for the benefit of the public. Recipients of this funding will assist SLTT agencies in conducting research, implementing intervention strategies, and performing other activities to reduce the occurrence of food-borne illness risk factors, reduce the burden of foodborne illness, and advance a nationally integrated food safety system.
Novel approaches to support therapeutic development in ultra-rare cancers
The purpose of this program is to support new approaches that can be applied to facilitate therapeutic development in ultra-rare pediatric and adult cancers, including molecularly-defined subsets of more common cancers. Specific areas of interest include, but are not limited to, the following examples: • Development of infrastructure for a coordination network and data repository for patient-level data across institutions and internationally to support drug development and regulatory decision-making for one or more ultra-rare cancers. • Investigations to explore opportunities to develop and validate early clinical endpoints and other novel efficacy endpoints for evaluation of treatments for ultra-rare cancers. • Development and implementation of a collaborative multi-stakeholder effort to support generation and use of real-world data leveraging a registry framework for use in development of new therapies for pediatric patients with diffuse midline glioma (DMG) (including diffuse intrinsic pontine glioma, DIPG). • Innovative approaches to identify new biologically-driven opportunities for clinical development of previously approved drugs or biologics (hereafter referred to as drugs), including drugs for which development has been discontinued, in ultra-rare cancers. • Research to develop novel approaches to preserve the availability of drugs for which commercial developers have discontinued adult development that have strong potential in ultra-rare cancers but lack financial incentives for commercial development • Development of methods to incorporate use of telemedicine and/or pragmatic trial design elements (e.g., collecting laboratory and/or imaging data from local facilities) for patient assessments to facilitate enrollment of patients with ultra-rare cancers • Development of nanoparticle-based delivery approaches for therapeutic nucleic acids targeting onco-fusion transcription factors in metastatic tumor animal models using targeted bioPROTAC degradation or genomic editing strategies. Successful efforts should demonstrate effective delivery and expression in-vivo to tumor cells, and downregulation of the target transcription factor protein while minimizing off-target effects and limiting sequestration of the nanoparticle by the liver, spleen, and lungs. • Research to exhaustively characterize the plasma-membrane protein expression (surfaceome) of an ultra-rare cancer and the presumed healthy tissue of origin, as well as the resident-tissue stem cells, by single-cell transcriptomics and proteomics. These studies, and available correlative database analyses, should be designed to identify possible combinatorial signatures of plasma membrane proteins unique to the ultra-rare tumor. Tumors of interest include Sclerosing epithelioid fibrosarcoma and atypical teratoid rhabdoid tumors (ATRT).
Collaborative Surveys to Provide Inputs into Vaccine-Related Economic Evaluations
The purpose of this notice of funding opportunity (NOFO) is to support research to obtain timely input from nationally representative samples of the public, including but not limited to patients and caregivers, on critical economic immunization issues of importance to public health. For example, productivity losses of child caregivers can be used as an input for a cost-effectiveness analysis of a pediatric vaccine in development. The objectives of this NOFO are: 1) to conduct multiple surveys of the public over the project period to collect immunization-related economic data, using scientifically sound methods with adequate response rates that produce generalizable results; and 2) to disseminate the results broadly to assist in economic evaluations for new vaccines and developing strategies to improve immunization coverage. Surveyed members of the public should be at least18 years old or older, and should include subpopulations such as pregnant women, parents of children aged 0–17 years, and persons with chronic medical conditions.
Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions
The National Institute of Dental and Craniofacial Research (NIDCR) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that—individually, sequentially, or in combination—contribute to human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses, e.g., causal explanation and causal inference—rather than statistical association, also are encouraged. Project results should be poised for clinical trials translation to prevent, treat, and manage dental, oral, and craniofacial (DOC) and related conditions. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area of behavioral, biological, biopsychosocial, public, and social sciences are encouraged to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in dental, oral, craniofacial, and systemic health over the life course, including care and services, will be encouraged, and these investigators also should begin to consider applying. NIDCR is authorized to forecast this opportunity under the Public Health Service Act (42 U.S.C §§ 241 and 284) and federal regulations (42 CFR Part 52 and 2 CFR Part 200).
HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems
Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers. Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.
Notice of Intent to Publish a Funding Opportunity Announcement for Impact of Technology and Digital Media Exposure Usage on Child and Adolescent Development
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the impact of technology and digital media on children and adolescents. Technology and digital media (TDM) encompasses social media, applications, websites, television, motion pictures, artificial intelligence, mobile devices, computers, video games, virtual and augmented reality, and other content, networks, or platforms disseminated through the internet, broadcasted, or other media technologies, as applicable. Collectively, they have become an integral part of our children’s and families’ daily lives. Most children and adolescents now engage with TDM starting from an early age, often with high levels of exposure across multiple devices and contexts and involving a wide range of content. There is therefore an urgent need to understand how TDM use and exposure impacts children’s health and development, as well as how it alters the very nature of interactions between children and their family members, peers, and society at large. As TDM has evolved with breathtaking speed, our understanding of its impacts – whether positive, neutral, or negative – on children’s health and development has not kept pace. This initiative intends to address this expanding gap by inviting research proposals on the impact of TDM on children and adolescents, including potential broader effects on their families and communities. Please note that applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize a phased R61/R33 mechanism. Investigators with interests at the intersection of TDM and child/adolescent development are encouraged to apply. In addition, collaborative teams that combine expertise across domains such as behavioral sciences, cognition and learning, computational and statistical modeling, computer science, geographic information science, library and information sciences, neurodevelopment, pediatrics, social and affective development and social sciences will be encouraged, and these investigators should also consider applying for this opportunity.
Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials
The Eunice Kennedy Shriver National Institute of Child Health and Human Development intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research focused on high-priority HIV studies for infants, children, youth and young adults (AYA), and maternal populations. An HIV clinical trials network focused exclusively on pediatric and maternal populations will innovate and conduct rigorously designed, collaborative clinical trials in partnership with site consortia to address high-priority research areas in HIV and related comorbidities and coinfections. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UM2 activity code. Investigators with expertise and insights into this area of HIV are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in chronic and infectious diseases, pediatrics, adolescent medicine, laboratory innovation, and cost-effectiveness will be encouraged and these investigators should also begin considering applying for this application.
Molecular, Neural, and Cognitive Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders
The National Institute on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to encourage basic research on Non-Invasive Brain Stimulation (NIBS) using animal and human models. NIBS techniques transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial focused ultrasound (tFUS) have emerged as promising approaches to treat addiction and substance use disorders (SUDs); however, their mechanisms of action are unclear. This initiative is to support research to (1) elucidate molecular, cellular, and circuit level changes induced by NIBS protocols (2) identify molecular mechanisms and pathways by which NIBS techniques and protocols produce their therapeutic effects in SUDs,(3) identify novel clinical targets for NIBS, and (4) investigate SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that may precede clinical outcomes. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into neuromodulation by non-invasive brain stimulation are encouraged to apply. In addition, collaborative investigations combining expertise in non-invasive brain stimulation and substance use and addiction are encouraged.
Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)
The National Institue on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on pioneering research in HIV and Substance use/substance use disorder (SUD) research. The Avant-Garde Award Program is designed to support exceptionally creative scientists who propose cutting edge high risk and high reward and possibly transformative approaches to major challenges in biomedical and behavioral research on HIV in the context of substance use and/or SUDs. This Program includes supporting early stage investigators (ESI). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the DP1 activity code. Investigators with expertise and insights into this area of substance use and HIV are encouraged to begin to consider applying for this new NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Data Analysis Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Administrative Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
Forecast to Publish a Funding Opportunity Announcement for Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
The National Institute on Drug Abuse (NIDA), with other NIH Institutes, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to support action-oriented research that accelerates the translation of addiction epidemiology, prevention, treatment, and recovery research to practice addressing both the opioid crisis and overdose events. Research supported under this initiative would focus on identifying and characterizing malleable factors and addressing barriers or facilitators to reducing substance use, misuse and overdose deaths at the individual, provider, organizational, community, or system levels. The emphasis would be on exploring and developing effective, replicable, and scalable approaches for accelerating the movement of evidence-based and promising treatments and preventive interventions into routine use. Specific priority areas would include, but not be limited to: recovery, prevention, pain/addiction intersections, engaging family and loved ones, transitions across care settings (e.g., inpatient treatment to community treatment), mental health integration, improving quality and efficiency of existing services and interventions, examining substance use and health outcomes and meaningful real-time data capture and use to improve services and public health approaches to reducing substance use, misuse, addiction, and overdose. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R61/R33 activity code. Investigators with expertise and insights into this area of addiction epidemiology, prevention, treatment, recovery and health services research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in modeling, health economics, implementation science, translation, or engagement science will be encouraged, and these investigators should also begin considering applying for this application.
Dementia CAReS Grants for American Indian and Alaska Native Communities
This is only a forecast. The synopsis and application package are not yet posted, and we have not yet finalized the application due date. This opportunity will be updated when it is published in Grants.gov. We want to achieve tangible, meaningful, and measurable action in every Tribal and Urban Indian community to positively impact the lives of people at risk of and living with dementia. This funding will support your efforts to design, implement, and promote activities nationally that help work towards that outcome. The four core strategies for this NOFO are to: · Provide “Mini-Grant” funding, training, technical assistance, and evaluation support to Tribal and Urban Indian clinical settings. Mini-Grant funding will support priority areas and address direct care, service, and training needs. Priority areas will be refined and finalized with us after the award. [AP(1] · Develop and support a “Call to Action” that identifies and connects a multi-disciplinary network of dementia champions and more broadly engages Tribal and Urban Indian communities. The Call to Action will help staff and communities learn from each other and work together to develop and achieve collective impact and improve outcomes. · Document and spread locally developed Tribal and Urban Indian Health emerging practices and success stories. The purpose is to increase awareness and promote innovation and change in clinical and community systems. Develop and implement an evaluation and data management plan, including the joint creation and testing of performance measures. The evaluation approach will track project [AP(1]Priority areas should be laid out in the application and guidance should be provided in the NOFO.
Health Equity Data Access Program (HEDAP)
The Health Equity Data Access program (HEDAP) provides funding for six (6) “seats” in the CMS Virtual Research Data Center (VRDC). The VRDC assists researchers in gaining access to CMS restricted data for minority health research. Seats, in this context are defined as an individual user with VRDC access. These researchers will conduct health services research on health care topics such as physical health, oral health, behavioral health, population health, and social determinants of health focusing on, but not limited to, racial and ethnic minority groups; people with disabilities; members of the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community; individuals with limited English proficiency; individuals residing in rural areas; and individuals (including children, youth, and families) adversely affected by persistent poverty or inequality. The HEDAP supports specific applied research projects that relate to creative and innovative methods utilizing CMS data to identify, document, assess, and evaluate health disparities among Medicare and Medicaid and CHIP enrollees. The project should enhance the capacity of the researcher to understand and utilize CMS data in future research projects. Additionally, HEDAP encourages cutting-edge proposals that explore intersectionality. “Intersectionality” means that people belong to more than one group and, therefore, may have overlapping health and social inequities, as well as overlapping strengths and assets. Results of the HEDAP will provide CMS and its partners, (e.g. Quality Improvement Organizations, Hospital Engagement Networks, and other stakeholders) with actionable information on the subgroups of enrollees. This will aid the efforts of CMS and its agents to identify and eradicate health disparities in underserved populations. VRDC seat access will be funded for a period of 36 months each, based on the availability of funds.
Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed
The intended outcome of this Notice of Funding Opportunity (NOFO) is to advance efforts for a nationally Integrated Food Safety System (IFSS) by supporting Manufactured Food Regulatory Program Standards (MFRPS), Food Protection Task Force (FPTF) programs, Dietary Supplement (DS) programs, and special projects. For the purposes of this NOFO, the term state encompasses all eligible organizations as defined in Section 3. MFRPS Development or Maintenance: The purpose of this Notice of Funding Opportunity (NOFO) section is to advance efforts for a nationally Integrated Food Safety System (IFSS) by assisting state manufactured food regulatory programs to achieve and maintain conformance with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS). The MFRPS are intended to ensure that state manufactured food regulatory programs implement a high-quality regulatory program through the development and maintenance of a regulatory framework that builds on and emphasizes mutual reliance with all programs. Also, the program standards are intended to enhance food safety by establishing a uniform basis for measuring and improving the performance of manufactured food regulatory programs in the United States. Conformance with these program standards will help federal and state programs better direct their regulatory activities at reducing foodborne illness hazards in plants that manufacture, process, pack, or hold foods. Food Protection Task Force (FPTF): The purpose of this funding option is to establish and/or support a Food Protection Task Force (FPTF) with diverse membership representative of stakeholders across the state that is responsible for promoting the integration of an efficient statewide human and animal food (HAF) protection system that addresses state and region-specific needs and that maximize the protection of the public health. These efforts include: establishing a food safety/protection network of subject matter experts, fostering educational opportunities, developing replicable resources and systematically fostering communication, education, outreach, cooperation and collaboration within the states among federal, state, local, tribal and territorial HAF protection, public health, agriculture, and regulatory agencies, industry, academia, and consumers to initiate and/or support HAF protection activities to improve public health. A strong FPTF can also help improve human and animal food emergency surveillance, response, and post-response systems by focusing on preparedness, building strong communication channels, and establishing relationships with key players before food-related incidents occur. Dietary Supplements: The goal of this funding option is to facilitate the development of state driven dietary supplement regulatory framework and programs. The overall objective of this funding opportunity is to advance the adoption and implementation of the cGMPs for Dietary Supplements Rule codified at 21 CFR Part 111. Specifically, this track will provide funding support for dietary supplement training and program development activities. Special Projects: The purpose of this funding option is to develop and implement special projects that support innovation and integration in a IFSS using the MFRPS framework. This track will support other emerging food safety priorities that develop over the lifespan of the project. State programs will be expected to share project deliverables and resources developed with other programs.
NHLBI Program Project Applications (P01 Clinical Trials Optional)
The National Heart, Lung, and Blood Institute (NHLBI) Program Project Grant (P01) supports research related to fundamental processes and diseases of the heart, blood and lymphatic vessels, lungs, and blood, including transfusion medicine, blood resources, and sleep disorders other programs including implementation science, health disparities, and translation research that address the mission of the Institute. This FOA requires a minimum of three interrelated research projects that investigate a complex biomedical theme or research question. The projects may be supported by core units, if justified, to facilitate economy of effort, space, and equipment. The NHLBI provides support for Program Project Grants (PPGs) in the belief that collaborative research efforts can accelerate the acquisition of knowledge more effectively than a simple aggregate of research projects that have no interaction or thematic integration. NHLBI is particularly interested in encouraging new scientific directions in PPGs. Use of the P01 activity code is viewed as an opportunity to attract scientists who have not traditionally been supported by the NHLBI. Further, the PPG environment presents an opportunity for emerging scientific leaders to gain insight into how to lead a successful scientific Program, and applicants will have the opportunity to include a project led by an Early Stage Investigator (ESI). All projects in the Program must be interrelated and have objectives that address a central theme within the scientific mandate of the NHLBI.