Prevention & Screening
Disease prevention, screening, and public health programs.
Strategic Prevention Framework - Partnerships for Success for Communities/Tribes
The purpose of the SPF-PFS-Communities/Tribes program is to help prevent and reduce the initiation and progression of substance use and its related problems by supporting the development and delivery of community-based substance use prevention services that strengthen protective factors, reduce risk factors, build resilience, and promote well-being; and expand and strengthen the capacity of prevention providers serving communities and tribes to implement evidence-based, evidence-informed, and community-defined evidence-based prevention strategies.
Screening, Brief Intervention and Referral to Treatment
The purpose of this program is to implement the Screening, Brief Intervention, and Referral to Treatment public health model for children, adolescents, and/or adults in primary care and community health settings (e.g., health centers, hospital systems, HMOs, PPOs, health plans, FQHCs, behavioral health centers, pediatric health care providers offices, children’s hospitals) and schools, with a focus on screening for underage drinking, opioid use, and other substance use.
Preventing Drug Overdoses: Community Prevention and Response
The purpose of this program is to develop and implement a community-wide prevention program of drug overdose deaths by expanding access to FDA-approved opioid overdose reversal medications.
State Pilot Program for Treatment for Pregnant and Postpartum Women
The purpose of this program is to strengthen and expand integrated, evidence-based substance use disorder (SUD) and maternal mental health services for pregnant and postpartum women and their families. The program seeks to improve maternal and infant health outcomes by addressing SUD and co-occurring substance use and mental health conditions through comprehensive screening, treatment, recovery supports, and workforce development. Priority populations include pregnant and postpartum women with primary diagnoses of SUDs, including opioid use disorder, and co-occurring mental health conditions, their infants and families, and communities disproportionately impacted by maternal morbidity and mortality.
Strategic Prevention Framework - Partnerships for Success for States
The purpose of the SPF-PFS States program is to help prevent and reduce the initiation and progression of substance use and its related problems by supporting the development and delivery of community-based substance use prevention services that strengthen protective factors, reduce risk factors, build resilience, and promote well-being; and expand and strengthen the capacity of prevention providers serving communities and tribes to implement evidence-based, evidence-informed, and community-defined evidence-based prevention strategies.
Promoting Integration of Primary and Behavioral Health Care: States
The purpose of this program is to: promote full integration and collaboration in clinical practices between physical and behavioral health care; support the improvement of integrated care models for physical and behavioral health care to improve overall wellness and physical health status; and promote the implementation and improvement of bidirectional integrated care services, including evidence-based or evidence-informed screening, assessment, diagnosis, prevention, treatment, and recovery services for mental and substance use disorders, and co-occurring physical health conditions and chronic diseases.
Tribal Opioid Response
The purpose of the TOR program is to assist in addressing the opioid overdose crisis in Tribal communities by increasing access to FDA-approved medications for opioid use disorder, and supporting the continuum of prevention, treatment, and recovery support services for opioid use disorder and co-occurring substance use disorders. This program also supports prevention, treatment, and recovery support services for stimulant misuse and use disorders, including those involving cocaine and methamphetamine.
Preventing Youth Overdose: Treatment, Recovery, Education, Awareness and Training
The purpose of this program is to improve local awareness among youth of risks associated with fentanyl, expand screening and diagnosis for opioid use disorder (OUD) among youth, increase access to medications for opioid use disorder (MOUD) for youth, and train healthcare providers, families, and school personnel on best practices for supporting youth with OUD and those taking MOUD.
Center of Excellence on Eating Disorders
The purpose of this program is to create a Center of Excellence for Eating Disorders. The Center will provide national training and technical assistance to healthcare providers on screening, brief intervention, and referral to treatment for eating disorders.
Screening & Treatment for Maternal Mental Health and Substance Use Disorders (MMHSUD)
The MMHSUD Program helps improve maternal mental health and substance use disorder outcomes for pregnant and postpartum women by providing obstetric, primary care, and other maternal health providers with timely access to teleconsultation, training, and care coordination support including resource and referrals.
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close gaps in health outcomes within the US population and increase health for all.Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, participant recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination. The application should also describe its approaches to increase community engagement from conceptual design of the intervention through implementation and sustainability, close gaps in health outcomes within the US population, and increase health for all.
Regional Pediatric Prevention Network
The purpose of this program is to support a Regional Pediatric Prevention Network (RPPN). The RPPN strengthens local and regional capacity to care for children during disasters and emergencies through community partnerships, coordinated pediatric preparedness, and dissemination of research-informed pediatric disaster care. The RPPN will include at least 10 children’s hospitals, or their university pediatric partners, funded through two primary awards. It will also include community partners working with these hospitals. Each of the 10 Children’s Hospital centers will advance pediatric emergency and disaster preparedness at the local, regional, and national levels, including for children with special health care needs and behavioral health concerns, children living in poverty, and children in rural, remote, and tribal areas.
Make America Healthy Again – Enhancing Lifestyle and Evaluating Value-based Approaches Through Evidence
The Centers for Medicare & Medicaid Services (CMS), through its Centers for Medicare and Medicaid Innovation (CMMI or Innovation Center), is soliciting applications for the Make America Healthy Again: Enhancing Lifestyle & Evaluating Value-based Approaches Through Evidence (MAHA ELEVATE) Model. This voluntary, three-year service delivery model is designed to test evidence-based, whole-person functional or lifestyle medicine (“whole-person FLM”) approaches to care. Rather than treating diseases separately after they develop, MAHA ELEVATE takes a proactive, comprehensive approach that combines psychological, nutritional, and physical interventions with personalized, lifestyle-based strategies for prevention and early treatment. Throughout this NOFO, we use the term “whole-person FLM” to represent a range of services or approaches often incorporated in lifestyle and functional medicine that are not currently covered under Medicare. It is important to clarify that CMS is not establishing a new industry standard through the use of this terminology. The term “whole-person FLM” as used in this NOFO does not represent an attempt by CMS to create, define, or establish any new industry-wide standard, practice guideline(s), or healthcare delivery model beyond the scope of this specific Innovation Center model and funding opportunity. Similarly, through this funding opportunity, CMS is not creating a new category of covered services for Medicare purposes. This term serves solely as a descriptive reference within this document to facilitate clear communication about the non-covered services being tested in this model and should not be interpreted as having any regulatory, coverage, or policy implications beyond the context of this specific Innovation Center model. CMS will select a total of up to 30 Recipients to participate in MAHA ELEVATE. The model will be split into two cohorts, one year apart (years 2026 and 2027). CMS will select recipients based on five key criteria: • Whole-person FLM intervention design, including cost savings. • Beneficiary recruitment and study design. • Organizational and administrative capacity. • Data management capabilities. • Budget. Highly competitive applicants must demonstrate several important strengths: • Strong, evidence-based support for your proposed intervention(s) and proof of your own successful history of implementation of the intervention and cost savings. • Ability to recruit large numbers of participants with a clear randomization plan and advanced data management capabilities. Given the model’s minimum beneficiary targets and extensive data management requirements, applicants who do not directly provide clinical care are strongly encouraged to form partnerships with care entities or organizations that deliver clinical care. This collaboration helps ensure you can meet the full operational requirements of the program.
Staff Sergeant Fox Suicide Prevention Grant Program Funding Opportunity
Description: The Department of Veterans Affairs (VA) is announcing the availability of funds for new and renewing suicide prevention grants under the Staff Sergeant Fox Suicide Prevention Grant Program (SSG Fox SPGP) for services in Federal Fiscal Year (FY) 2027. The SSG Fox SPGP directs efforts to reduce Veteran suicide by awarding grants to community-based organizations to directly provide or coordinate the provision of primarily non-clinical suicide prevention services to eligible individuals and their families. Eligible individuals include certain Veterans and Active-Duty Service Members as defined by statute and regulations. Veteran suicide risk is reduced by services that improve mental health status, well-being, financial stability, and social support. Services provided by grantees may include case management, peer support, linkage to VA care and benefits, emergency clinical services, faith-based or innovative approaches. Most Veterans who die by suicide were not engaged with VA in the years prior to their deaths. This program addresses a critical gap by engaging and serving Veterans at risk for suicide who were previously out of VA’s reach and their family members. These grants support the President’s commitment to increase the excellence of and options for care, benefits, and services for veterans, as well as improve the delivery and quality of the Department's healthcare services in a more efficient and effective manner to support veterans, as demonstrated in Executive Order 14296 – Keeping Promises to Veterans and Establishing a National Center for Warrior Independence. This NOFO contains information concerning the SSG Fox SPGP, the grant application process, and the amount of funding available. For detailed program information and requirements, see 38 C.F.R. Part 78.
Drug-Free Communities (DFC) Support Program – NEW (Year 1)
The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2026 Drug-Free Communities (DFC) Support Program grants. The purpose of the DFC Support Program is to establish and strengthen collaboration to support the efforts of community coalitions working to prevent youth substance use. By statute, the DFC Support Program has two goals: 1) Establish and strengthen collaboration among communities, public and private non-profit agencies, as well as federal, state, local, and tribal governments to support the efforts of community coalitions working to prevent and reduce substance abuse among youth (individuals 18 years of age and younger). 2) Reduce substance abuse among youth and, over time, reduce substance abuse among adults by addressing the factors in a community that increase the risk of substance abuse and promoting the factors that minimize the risk of substance abuse.
Drug-Free Communities (DFC) Support Program – COMPETING CONTINUATION (Year 6)
The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2026 Drug-Free Communities (DFC) Support Program Grants. The purpose of the DFC Support Program is to establish and strengthen collaborations to support the efforts of community coalitions working to prevent and reduce substance use among youth. By statute, the DFC Support Program has two goals: 1) Establish and strengthen the collaboration among communities, public and private non-profit agencies, as well as federal, state, local, and tribal governments to support the efforts of community coalitions working to prevent and reduce substance use among youth (individuals 18 years of age and younger). 2) Reduce substance use among youth and, over time, reduce substance use among adults by addressing the factors in a community that increase the risk of substance use and promoting the factors that minimize the risk of substance use. This funding opportunity will fund applicants who have concluded the first (Year 1 – 5) funding cycle or have experienced a lapse in funding.
Comprehensive Addiction and Recovery Act (CARA)
The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2026 Comprehensive Addiction and Recovery Act (CARA) Community-based Coalition Enhancement Grants to Address Local Drug Crises Grants (CARA Local Drug Crises Grants) as an enhancement to current or formerly funded Drug-Free Communities (DFC) Support Program recipients. The purpose of this program is to prevent and reduce the use of opioids and methamphetamines and the misuse of prescription drugs among youth ages 12-18 in communities throughout the United States.
Senior Medicare Patrol State Project Grants - Pennsylvania
The mission of the Administration for Community Living (ACL) Senior Medicare Patrol (SMP) program is to empower and assist Medicare beneficiaries, their families, and caregivers to prevent, detect, and report health care fraud, errors, and abuse. Through outreach, counseling, and education, the SMP program increases awareness and understanding of health care programs to protect Medicare beneficiaries from the economic and health-related consequences associated with Medicare fraud, errors, and abuse. ACL currently provides grant funding to support 54 SMP state projects, including grantees in all 50 states, the District of Columbia, Puerto Rico, Guam, and the US Virgin Islands. The SMP projects use this funding to provide local outreach, education, and assistance to Medicare beneficiaries through a trained workforce, many of which are volunteers. SMP projects teach Medicare beneficiaries to protect their Medicare numbers, to detect billing discrepancies on their Medicare statements, and to report suspicious activity for further investigation. In addition, SMP projects actively disseminate fraud prevention and identification information through the media, outreach campaigns, and community events. As a result of these efforts, beneficiaries contact the SMP projects with inquiries and complaints regarding potential Medicare fraud, errors, and abuse. SMPs provide in-depth counseling and assistance to help beneficiaries who present with questions and issues. With this funding opportunity, ACL anticipates awarding up to 1 cooperative agreement to support the SMP project in Pennsylvania.
Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials
The National Institute on Drug Abuse seeks to support pilot and feasibility studies in preparation for efficacy, effectiveness and/or services research trials. Topics may include:1) developing interventions to prevent substance use, misuse or progression to disorder, 2) substance use prevention, treatment or recovery services research, including comorbid pain, medical and mental health disorders, 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations. Projects may address information gaps, strengthen stakeholder partnerships, or pilot test interventions. Activities might include intervention development/adaptation; assessing intervention or service model acceptability and feasibility; and development of measures, materials, or methods for the future trial. Preliminary data is not required. A well-defined theory of change or logic model is expected. Applicants must engage relevant end users in study design, execution, and interpretation (e.g., policymakers, state and local decision makers, practitioners, individuals with lived/living experience, families, youth, and community members). Applications are not being solicited at this time. This notice is to allow applicants time to develop collaborations and responsive projects. Grant authorities that allow this forecast are 42 U.S.C. §§ 241 and 284.
Traumatic Brain Injury State Partnership
The purpose of this grant program is to improve the health and well-being of individuals with traumatic brain injuries (TBI) by streamlining access to critical resources, services, and supports for people who have sustained a TBI as well as leveraging resources for sustainability. Supported activities may include information and referral services for people with TBI and their caregivers, resource facilitation, outreach and awareness to communities about TBI, and brain injury screenings and trainings to community stakeholders and paraprofessionals. Funds may also support activities that promote comprehensive services and trainings for population with a higher prevalence of people impacted by brain injury, such as veterans, youth, individuals in the criminal legal system, and aging populations.
Telehealth Nutrition Services Network Grant Program
The Telehealth Nutrition Services Network Grant Program will support telehealth networks that improve access to quality health care services through telehealth technology. This program will focus on chronic disease prevention and chronic disease management through comprehensive telehealth nutrition services.
Rural Communities Opioid Response Program (RCORP)-Planning
Rural Communities Opioid Response Program (RCORP)-Planning supports organizations in rural communities to build the partnerships and foundational capacity needed to develop, implement and sustain a comprehensive system of substance use disorder (SUD) and related services. RCORP’s focus is on opioid misuse and its impact on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Individuals struggling with SUD, including opioid use disorder (OUD), need a continuum of mental, behavioral, and related social supports. RCORP-Planning helps address these needs in a comprehensive way. This program is intended for rural communities that may find the logistics or requirements of larger, more complex federal grant programs to be barriers to accessing start-up support. Funding will serve as a critical first step to creating SUD service systems that make care easy to access, strengthen the behavioral health workforce, and have strong community buy-in. It will help prepare communities to provide sustainable prevention, treatment, recovery, and other supportive services that: reduce substance use initiation and misuse,address the mental, behavioral, and psychosocial needs of people who use illicit substances or misuse alcohol, or are in recovery from substance use problems, andreduce disease and death related to substance use problems, including OUD, in high-risk rural communities.The intent of this program is to fund planning activities only. Funds may not be used for direct service delivery.
Rural Communities Opioid Response Program (RCORP)-Impact
The Rural Communities Opioid Response Program (RCORP)–Impact funds rural communities to drive measurable improvements in access to integrated, coordinated treatment and recovery services for substance use disorder (SUD), including opioid use disorder (OUD). Its long-term aim is to reduce morbidity and mortality associated with SUD and enable sustained recovery and well-being. The program supports: New or expanded evidence-based SUD prevention, treatment, and recovery services in rural areas;Coordination across health and supportive social services to enable sustained, long-term recovery;A larger, more responsive workforce to address SUD-related needs; andMulti-sector community networks to strengthen and sustain local service delivery.The focus of RCORP-Impact is on reducing the impact of opioid misuse on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Therefore, RCORP-Impact supports a comprehensive approach to address all SUD, including OUD, within a continuum of mental, behavioral, and related social supports.
Early Childhood Comprehensive Systems SEED Project: Scaling Effective Early Childhood Systems Development (ECCS SEED)
The purpose of the Early Childhood Comprehensive Systems SEED Project: Scaling Effective Early Childhood Systems Development (ECCS SEED) is to address the root causes of chronic disease in early childhood by improving families’ access to health care, screening kids early for physical and mental health needs, and connecting parents to services that enable them to provide for their children. The ECCS SEED Project will partner with states and communities to support evidence-based strategies that improve access to quality care for prenatal-to-age-5 (P-5) families and promote healthy child development and family well-being.
Adult Suicide Prevention
The purpose of this program is to implement suicide prevention and intervention programs for adults, 18 years of age or older. This is accomplished by taking a broad-based public health approach to suicide prevention through enhanced collaboration with key community stakeholders, raising awareness of available suicide prevention resources, and implementing lethal means safety.
Garrett Lee Smith Campus Suicide Prevention
The purpose of this program is to support a comprehensive public health and evidence-based approach that: (1) enhances behavioral health services for all college students, including those at risk for suicide, depression, serious mental illness (SMI)/serious emotional disturbances (SED), and/or substance use disorders that can lead to school failure; (2) prevents and reduces suicide and mental and substance use disorders; (3) promotes help-seeking behavior and reduces stigma; and (4) improves the identification and treatment of at-risk college students so they can successfully complete their studies. Note: Cost-sharing is waived for minority-serving institutions and community colleges.
Garrett Lee Smith State/Tribal Youth Suicide Prevention and Early Intervention Program
The purpose of this program is to support States and Tribes in implementing suicide prevention and early intervention strategies for youth, up to the age of 24 years, in schools, educational institutions, juvenile justice systems, substance use and mental health programs, foster care systems, pediatric health programs, and other child- and youth-serving organizations.
Centers for AIDS Research (CFAR)
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for the Centers for AIDS Research (CFAR). The national network of CFARs cooperates with other HHS-funded HIV/AIDS programs to establish and maintain the collaborations and infrastructure required to carry out innovative implementation science research for ending the HIV epidemic domestically. Addressing a complex chronic disease, HIV/AIDS research requires broad scientific expertise, access to unique biological samples, and cutting-edge research technologies that extend beyond the needs of individual research groups. The CFAR program strengthens HIV/AIDS research by providing infrastructure that fosters multidisciplinary collaborations, maximizes efficiencies by reducing duplication of efforts, and leverages economies of scale to facilitate the translation of basic research findings into new HIV treatment, prevention, and cure approaches. A core mission of the CFAR program is to support and mentor early-career investigators and investigators new to HIV/AIDS research by funding pilot studies, emerging research opportunities, and high-risk/high-impact collaborative studies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Implementation Science to End the HIV Epidemic
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by continuing support for implementation science to end the HIV epidemic. Projects will leverage research-community collaborations to bring evidence-based advances in HIV prevention, diagnosis, treatment, and cluster outbreak response to communities disproportionately impacted by HIV. The goals of these projects will be to: (1) Develop strategies to end HIV by integrating innovations across disciplines such as epidemiology, data science, public health, medicine, social services, implementation science, and community engagement, and (2) Deploy, test, and evaluate new or existing strategies at multiple geographic locations or settings. While deployment of these strategies will occur at the local scale, through partnerships with, local, state, and federal public health partners, the overall program will advance generalized knowledge that informs larger scale efforts to end HIV. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Sustaining life-saving HIV services in Ukraine by strengthening resilient health systems under the Ukraine Ministry of Health, Public Health Center
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $10,000,000 for Year 1, subject to the availability of funds. This NOFO aims to help the Public Health Center (PHC) of the Ministry of Health (MOH) enhance life-saving assistance for HIV and associated prevalent health conditions. This should be accomplished with targeted HIV testing, prevention, and treatment activities amid ongoing instability. The objectives of this NOFO include: Working to ensure that targeted HIV testing, treatment, retention, and prevention services are widely available for people who are at higher risk for HIV. Services should be provided in community settings using social network strategies (SNS). Activities include:Targeted community-based case finding.Immediate linkage to available treatment.Retention support.Management of advanced HIV disease and HIV/TB co-infection.Improving the availability of HIV services by mobile HIV testing, treatment, and prevention. You should use targeted mobile HIV case finding, treatment, retention, and prevention services. Activities include:Streamlining immediate linkage to treatment.Strengthening ongoing adherence support.Improving the availability and quality of HIV services at medical facilities by implementing differentiated service delivery (DSD) models. Activities include enhancing patients’ retention, adherence, and access to HIV services at the facility level.Enhancing essential, targeted HIV prevention service provision for people at higher risk for HIV, focusing on availability, quality, coverage and timely initiation.
Engaging faith-based organizations to sustain lifesaving HIV and TB services in Ethiopia
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $5,000,000 for Year 1, subject to the availability of funds. This NOFO will engage faith-based organizations (FBOs) to support and sustain lifesaving HIV, TB, and cervical cancer services in Ethiopia. HIV services will include: • HIV testing. • HIV prevention, including vertical transmission. • Adult and pediatric HIV care and treatment. Through this project, you will work with faith communities to provide and link people with lifesaving HIV services. You will serve: • People at high risk of acquiring HIV. • Undiagnosed people living with HIV • People living with HIV at risk of interrupting their treatment. • Pregnant and breastfeeding women. • People living with HIV who may face barriers to accessing conventional health facility services. You will be expected to implement cost-efficient models and integrate them with the routine health-care delivery system to reach undiagnosed people living with HIV, people living with HIV who have defaulted from care, and people at high risk of acquiring HIV, ensuring their access to critical, lifesaving HIV and TB services. This NOFO will support activities that promote country ownership and country-led plans that enable greater sustainability. Programs supporting other public health threats and emergencies in Ethiopia may also be included in this NOFO.
Strengthening Botswana's national data, performance management, and surveillance systems for a sustainable and government-led HIV, TB, and related public health response
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $4,000,000 for Year 1, subject to the availability of funds. This NOFO aims to provide targeted strategic assistance to the Government of Botswana (GOB) to strengthen health security and national data systems. It focuses on: Governance and policies.Capacity building to sustainably manage data.System functionality, interoperability, and data use.You are expected to support the GOB to help ensure that comprehensive, quality HIV-related strategic information and health security systems operate effectively at the site, district, and national levels. Your activities should include: Transferring skills and management of technology systems to GOB so it can operate, maintain, and use current facility, community, and national data systems. These systems include any paper and electronic record systems necessary to manage patients and monitor programs that deliver lifesaving HIV and TB care, treatment, and targeted prevention services.Transferring skills and technology related to existing country data systems to GOB. This includes systems that ensure routine program monitoring, oversight, compliance, and reporting. This also includes enhancing workforce knowledge and skills to operate, maintain, and secure the systems and analyze data.Strengthen the health security capacities of the GOB and relevant interest holders to surveil, respond to, and control public health events and disease outbreaks across all administrative levels.
Improving regional capacity to respond to HIV, TB, and other global health priorities in Central America
The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $20,000,000 for Year 1, subject to the availability of funds. You will advance progress towards achieving the 95-95-95 targets and continue to transition site-level support to local governments in Central America (CA) for: El Salvador.Guatemala.Honduras.Nicaragua.Panama.To achieve the goals of this NOFO, you will address gaps in: HIV prevention.Diagnosis.Life-saving treatment.Proposed activities should facilitate country ownership while improving local capacity to: Make sure HIV prevention is available for populations most at risk, through the Sentinel Surveillance of STI and HIV Strategy (VICITS).Provide testing that leads to active linkage to HIV treatment and prevention services.Improve early HIV diagnosis through active case-finding strategies, including:Testing as outreach for populations most at risk for HIV.Index, provider-initiated, and community testing.Social network strategy.Self-testing.Support the integration of comprehensive care and treatment services, including for HIV, TB, and other opportunistic infections.Build capacity of healthcare workers to provide high-quality health services led by the country, and through continuous quality improvement (CQI) initiatives.Make sure adequate data systems are used to monitor progress toward 95-95-95 targets and other global health priorities.Support sustainable health systems that improve:Efficiency.Country ownership of the program.Global health security to fight priority infectious diseases and other public health threats.
Building National Partnerships for the Prevention of Emerging and Reemerging Infectious Diseases
This cooperative agreement establishes a single, integrated funding mechanism aimed at enhancing the nation's ability to prevent, detect, and respond to infectious disease threats. It will support clinicians, healthcare professionals, healthcare systems, institutions, and organizations directly involved in patient care, public health, and infectious disease control across the United States. By strengthening the capacity of these key stakeholders, the program will enable more effective frontline engagement, facilitate the implementation of timely public health responses, and generate expert insights to inform and improve public health guidance and practice. The program will focus on building and sustaining critical infrastructure, workforce training, communication strategies, and emergency response capabilities needed to address both emerging and reemerging infectious diseases. Emphasis will be placed on expanding national infection prevention capacity through targeted education and training initiatives, particularly in the areas of antimicrobial resistance and infection control. Additionally, the program will enhance preparedness by supporting surge staffing and fostering coordination among healthcare and public health partners during emergency response efforts.
A Demonstration to Scale Innovative Person-Centered Approaches to Falls Prevention through Clinical-Community Partnerships
The purpose of this funding announcement is to demonstrate and evaluate the scalability of person-centered and evidence-based approaches to falls prevention that leverage clinical and community partnerships and related data and technology tools. ACL intends to award a single cooperative agreement to one grantee for a three-year project period with the expectation that the grantee will fund up to three demonstrations. This award will build on the ACL Innovation Lab to demonstrate the scaling of person-centered and evidence-based approaches to falls prevention and related chronic disease management programs through community care hubs and their respective clinical partners and community-based organizations in the aging services network. The successful applicant will be expected to collaborate with ACL in the design and implementation of these demonstrations in the scalability of falls prevention and related chronic disease management interventions through approximately three advanced community care hubs that support care transitions and screening for the risk of falls. They should also have the capacity to 1) do rapid cycle evaluation to iterate and improve the impact of the interventions as they are scaled and, 2) administer sub-awards to community care hubs that can implement and scale person-centered interventions enabled by artificial intelligence, data analytics, assistive technology, virtual delivery of interventions, tools to support consumer behaviors, and related data infrastructure.
ACL National Falls Prevention Resource Center
The purpose of this Notice of Funding Opportunity is to support one organization through a cooperative agreement to serve as the National Falls Prevention Resource Center. This center will act as a central connector to the aging network for the discretionary and formula funded Falls Prevention grants. It will offer individualized and tiered technical assistance, high-quality education, and a wide range of resources to increase the number of older adults and adults with disabilities who participate in evidence based Falls Prevention Programs. The Resource Center will help the network provide cost-effective services that align with the purposes of the Older Americans Act, Title III-D. They will promote the advancement of the Falls Prevention network through building partnerships, supporting data collection, reporting metrics, highlighting key achievements, and engaging stakeholders to encourage long-term sustainability of the programs.
Advancing Whole-Person Health: Enhancing Networks of Community-Based Aging and Disability Organizations to Improve Access to Long-Term Services and Supports
ACL intends to award a single cooperative agreement to one grantee for a three-year project period. This award will support a regional community care hub (CCH) scaling strategy to expand access to long-term services and supports (LTSS) for older adults and people with disabilities as part of a broader No Wrong Door System effort. The successful applicant will be expected to collaborate with ACL to support approximately three regional advanced CCHs to enable CCH scaling through shared infrastructure services and alignment with existing CCHs and other community-based aging and disability organizations. They should also have the capacity to provide technical assistance to the selected super hubs as they work to expand their infrastructure capacity to support streamlined access to LTSS through health care payer partnerships, with services inclusive of care transitions, care coordination, and evidence-based prevention/health promotion programs.
Ending the HIV/HCV Epidemics in Indian Country
The purpose of this program is to support communities to directly increase the diagnoses, treatment, and prevention of HIV, HCV, and syphilis. Successful applicants will work toward a re-duction of new HIV infections and relevant co-morbidities, specifically syphilis and HCV infections; improve HIV/HCV/syphilis-related health outcomes; and reduce HIV/HCV/syphilis-related health disparities among the AI/AN population. In four separate but related parts, this initiative aims to implement effective and innovative strategies, interventions, approaches, and services to reduce new HIV/HCV/syphilis infections among AI/AN communities in the U.S. This initiative’s overarching goals are to: (1) Reduce new HIV, HCV, and syphilis infections to less than 3,000 per year by 2030; and (2) achieve a 90 percent reduction in new HCV infections and a 65 percent reduction in mortality, compared to a 2015 baseline.
Grants to Support New Investigators in Conducting Research Related to Preventing Interpersonal Violence and Suicide Among Children and Youth (K01)
This Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) Mentored Research Scientist Development Award (K01) helps researchers develop skills in violence prevention research. The goal is to support scientists in becoming independent researchers. Applicants must propose a research project that focuses on at least one of the following NCIPC research priorities related to interpersonal violence and suicide affecting children and youth (birth to age 17). These research priorities include adverse childhood experiences, child abuse and neglect, youth violence, intimate partner violence (including teen dating violence), sexual violence, suicide, and cross-cutting preventions (i.e. examining two or more of these priority topics). For more information, see https://www.cdc.gov/injury-violence-prevention/programs/research-priorities.html. Applicants are encouraged to explore multiple forms of interpersonal violence and/or suicide among children or youth, community factors that increase the risk of interpersonal violence and/or suicide, and the practical relevance of the research for prevention and intervention efforts.
Collaborative Surveys to Provide Inputs into Vaccine-Related Economic Evaluations
The purpose of this notice of funding opportunity (NOFO) is to support research to obtain timely input from nationally representative samples of the public, including but not limited to patients and caregivers, on critical economic immunization issues of importance to public health. For example, productivity losses of child caregivers can be used as an input for a cost-effectiveness analysis of a pediatric vaccine in development. The objectives of this NOFO are: 1) to conduct multiple surveys of the public over the project period to collect immunization-related economic data, using scientifically sound methods with adequate response rates that produce generalizable results; and 2) to disseminate the results broadly to assist in economic evaluations for new vaccines and developing strategies to improve immunization coverage. Surveyed members of the public should be at least18 years old or older, and should include subpopulations such as pregnant women, parents of children aged 0–17 years, and persons with chronic medical conditions.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Data Analysis Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.
Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Administrative Resource (U24 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
Forecast to Publish a Funding Opportunity Announcement for Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) launched the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) in 2012 to determine how adolescent alcohol-related disruption of normal brain growth patterns of structure, related brain function, and psychiatric health affects brain functioning in emerging adulthood. The consortium uses an accelerated longitudinal design and has acquired data on over 800 individuals between the ages of 12 to 32 years. This wide age range covers the period before onset of drinking, the transition from adolescence to young adulthood, the critical period for binge drinking, and the time of maturing out. This unique dataset provides novel information on the enduring and transient consequences of adolescent drinking on adult brain function and behavior. Current studies on adults drinking do not have this type of data. Renewal of this limited competition NOFO will enable NCANDA to continue to follow these participants up to 37 years of age and acquire data critical to understanding how early versus late onset drinking during adolescence differentially impacts drinking behavior in adulthood. This limited competition renewal will provide valuable information for developing evidence-based alcohol prevention strategies and early intervention approaches to prevent the progression to more severe drinking and AUD thereby preventing the development of chronic disease, improving health outcomes, and increasing quality of life and longevity. Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of developmental neuroscience are encouraged to begin to consider applying for this new NOFO.
HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
The National Institute on Drug Abuse (NIDA), with other NIH Institutes, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to support action-oriented research that accelerates the translation of addiction epidemiology, prevention, treatment, and recovery research to practice addressing both the opioid crisis and overdose events. Research supported under this initiative would focus on identifying and characterizing malleable factors and addressing barriers or facilitators to reducing substance use, misuse and overdose deaths at the individual, provider, organizational, community, or system levels. The emphasis would be on exploring and developing effective, replicable, and scalable approaches for accelerating the movement of evidence-based and promising treatments and preventive interventions into routine use. Specific priority areas would include, but not be limited to: recovery, prevention, pain/addiction intersections, engaging family and loved ones, transitions across care settings (e.g., inpatient treatment to community treatment), mental health integration, improving quality and efficiency of existing services and interventions, examining substance use and health outcomes and meaningful real-time data capture and use to improve services and public health approaches to reducing substance use, misuse, addiction, and overdose. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R61/R33 activity code. Investigators with expertise and insights into this area of addiction epidemiology, prevention, treatment, recovery and health services research are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in modeling, health economics, implementation science, translation, or engagement science will be encouraged, and these investigators should also begin considering applying for this application.
HIV Prevention and Alcohol (R01 Clinical Trials Optional)
The NOFO seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. This includes integration of effective prevention and treatment interventions with an understanding of the overarching framework for reducing the incidence of new infections by facilitating cross-cutting informative research. This research activity includes the development and testing of new interventions and expansion of existing effective interventions as well as the implementation of these integrative preventive activities in a variety of settings and populations. Six areas of research are of primary interest related to alcohol use and related mental health and substance use comorbidities. These include but are not limited to 1) PrEP Utilization, 2) Treatment as Prevention (TasP), 3) Integration of Preventive Intervention Strategies, 4) Prevention-related Cross-cutting Research, 5) Syndemic Approaches and, 6) Implementation and Operations Research.